Materials and methods: This is a prospective longitudinal study of 30 patients diagnosed with unilateral vocal fold paralysis at Civil Hospital, Ahmedabad and underwent treatment for the same between a period of June, 2019 to December, 2021.

Result: Left vocal cord palsy was more common as compared to right, left recurrent laryngeal nerve is more frequently involved because of longer course. All patients had primary complaint of hoarseness of voice, breathiness was the next common presenting complaint, followed by vocal fatigue. An improvement in both subjective parameters was seen post treatment.

Conclusion: Conservative treatment in form of speech therapy was given to the patients (43%) which helped in improvement of voice quality but not glottic insufficiency. Improvement was seen mainly due to compensatory mechanism. Adequate glottic closure was achieved by both surgical methods that we used. The quality of voice of patients improved significantly.

Keywords: ENT; Unilateral Vocal Fold Paralysis; Fat Augmentation; Thyroplasty

References

1. Bidossi Alessandro., et al. "Identification and Characterization of Planktonic Biofilm-Like Aggregates in Infected Synovial Fluids from Joint Infections”. Frontiers in Microbiology 11 (2020).
2. Mendhe Snehal., et al. "Impact of Biofilms on Chronic Infections and Medical Challenges”. Cureus (2023).
3. Assefa Misgana and Ashenafi Amare. "Biofilm-Associated Multi-Drug Resistance in Hospital-Acquired Infections: A Review”. Infection and Drug Resistance 15 (2022): 5061-5068.
4. Sharma Surbhi., et al. "Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment”. Microorganisms6 (2023): 1614.
5. Pai Lavanya., et al. "A Growing Battlefield in the War against Biofilm-Induced Antimicrobial Resistance: Insights from Reviews on Antibiotic Resistance”. Frontiers in Cellular and Infection Microbiology 13 (2023).
6. Lusiak-Szelachowska Magdalena., et al. "Bacteriophages and Lysins in Biofilm Control”. Virologica Sinica2 (2020): 125-133.
7. Schulze Alexander., et al. "Biofilms by Bacterial Human Pathogens: Clinical Relevance—Development, Composition and Regulation—Therapeutical Strategies”. Microbial Cell2 (2021): 28-56.
8. Diban Federica., et al. "Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model”. International Journal of Molecular Sciences2 (2023): 1004.
9. Omar A., et al. "Microbial Biofilms and Chronic Wounds”. Microorganisms1 (2017): 9.
10. Busscher H J and HJ Van Der Mei. "Physico-Chemical Interactions in Initial Microbial Adhesion and Relevance for Biofilm Formation”. Advances in Dental Research1 (1997): 24-32.
11. Flemming HC., et al. "Biofilms: An Emergent Form of Bacterial Life”. Nature Reviews Microbiology9 (2016): 563-575.
12. Flemming HC. "Biofilms”. Encyclopedia of Life Sciences (2008).
13. James GA., et al. "Biofilms in Chronic Wounds”. Wound Repair and Regeneration1 (2007): 37-44.
14. Bowers S and E Franco. "Chronic Wounds: Evaluation and Management”. PubMed3 (2020): 159-166.
15. Falcone M., et al. "Challenges in the Management of Chronic Wound Infections”. Journal of Global Antimicrobial Resistance 26 (2021): 140-147.
16. Serra R., et al. "Chronic Wound Infections: The Role of Pseudomonas Aeruginosa and Staphylococcus Aureus”. Expert Review of Anti-Infective Therapy5 (2015): 605-613.
17. Rahim K., et al. "Bacterial Contribution in Chronicity of Wounds”. Microbial Ecology3 (2016): 710-721.
18. Di Domenico E., et al. "Biofilm Is a Major Virulence Determinant in Bacterial Colonization of Chronic Skin Ulcers Independently from the Multidrug Resistant Phenotype”. International Journal of Molecular Sciences 5 (2017): 1077.
19. Freeman D J., et al. "New Method for Detecting Slime Production by Coagulase Negative Staphylococci”. Journal of Clinical Pathology8 (1989): 872-874.
20. Hassan A., et al. "Evaluation of Different Detection Methods of Biofilm Formation in the Clinical Isolates”. The Brazilian Journal of Infectious Diseases4 (2011): 305-311.
21. Mah TF. "Biofilm-Specific Antibiotic Resistance”. Future Microbiology9 (2012): 1061-1072.
22. Madhumati B., et al. "Prevalence of AMPC Beta Lactamases among Gram Negative Bacterial Isolates in a Tertiary Care Hospital”. International Journal of Current Microbiology and Applied Sciences9 (2015): 219-227.
23. Anwar H., et al. "Susceptibility of Biofilm Cells of Pseudomonas Aeruginosa to Bactericidal Actions of Whole Blood and Serum”. FEMS Microbiology Letters 71 (1992): 235-241.
24. , et al. "The Role of Oxygen Limitation in the Resistance of Agar-Entrapped, Sessile-Like Escherichia Coli to Aminoglycoside and Beta-Lactam Antibiotics”. Journal of Antimicrobial Chemotherapy 36 (1995): 521-526.
25. Davies DG., et al. "The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm”. Science 280 (1998): 295-298.
26. Desai M., et al. "Increasing Resistance of Planktonic and Biofilm Cultures of Burkholderia Cepacia to Ciprofloxacin and Ceftazidime during Exponential Growth”. Journal of Antimicrobial Chemotherapy 42 (1998): 153-160.
27. Greendyke R and T F Byrd. "Differential Antibiotic Susceptibility of Mycobacterium Abscessus Variants in Biofilms and Macrophages Compared to That of Planktonic Bacteria”. Antimicrobial Agents and Chemotherapy 52 (2008): 2019-2026.
28. Munoz-Egea MC., et al. "Effect of Antibiotics and Antibiofilm Agents in the Ultrastructure and Development of Biofilms Developed by Nonpigmented Rapidly Growing Mycobacteria”. Microbial Drug Resistance 22 (2016): 1-6.
29. Shenoy V., et al. "Detection of Biofilm Production and Its Impact on Antibiotic Resistance Profile of Bacterial Isolates from Chronic Wound Infections”. Journal of Global Infectious Diseases3 (2020): 129.
30. Karimi K., et al. "Investigation of Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Klebsiella Pneumoniae”. International Journal of Microbiology (2021): 1-6.
31. Shravani V., et al. "Detection of Quorum Sensing Virulence Factor Genes and Its Consanguinity to Antibiotic Sensitivity Profile in the Clinical Isolates of Pseudomonas Aeruginosa”. PubMed8 (2023): 899-905.
32. Bhatt P., et al. "Prevalence of Multidrug Resistant Pseudomonas Aeruginosa Infection in Burn Patients at a Tertiary Care Centre”. Indian Journal of Burns1 (2015): 56.
33. Ahmed A J A and H A A Alaa. "Virulence Factors and Antibiotic Susceptibility Patterns of Multidrug Resistance Klebsiella Pneumoniae Isolated from Different Clinical Infections”. African Journal of Microbiology Research22 (2016): 829-843.
34. Nirwati H., et al. "Biofilm Formation and Antibiotic Resistance of Klebsiella Pneumoniae Isolated from Clinical Samples in a Tertiary Care Hospital, Klaten, Indonesia”. BMC Proceedings11 (2019).
35. Jamal Muhsin., et al. “Bacterial Biofilm and Associated Infections”. Journal of the Chinese Medical Association1 (2017): 7-11.
36. Schulze A., et al. "Biofilms by Bacterial Human Pathogens: Clinical Relevance - Development, Composition and Regulation - Therapeutical Strategies”. Microbial Cell 2 (2021): 28-56.
37. Dan B., et al. "Relationship between Drug Resistance Characteristics and Biofilm Formation in Klebsiella Pneumoniae Strains”. Infection and Drug Resistance 16 (2023): 985-998.
38. Hadla M and Halabi MA. “Effect of Quorum sensing”. In : Chormey DS, Bakirdere S, Turan NB, Engin GO (end), Comprehensive analytical chemistry. Elsevier, Randarweg, Amsterdam, Netherlands 81:95-116.

Citation

Citation: Divyanshu Sharma., et al. “A Clinical Study on Unilateral Vocal Fold Paralysis and its Management at Tertiary Care Hospital".Acta Scientific Otolaryngology 7.8 (2025): 16-20.

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Copyright: © 2025 Divyanshu Sharma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.