Prankur Verma, Kapil Sikka¹*, Hitesh Verma¹, Alok Thakar¹, Dipendra K Mitra², Divya Kamboj² and Abhinav Saurabh²

¹Department of ENT, All India Institute of Medical Sciences, New Delhi, India
²Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India

*Corresponding Author: Kapil Sikka, Department of ENT, All India Institute of Medical Sciences, New Delhi, India.

Received: May 27, 2025; Published: June 18, 2025

Abstract

Background: Phagocytes play an important role in fungal cell recognition and damage through oxidative and non oxidative methods.

Objectives: This study investigated the phagocyte oxidative function in invasive fungal sinusitis.

Methods: The peripheral blood of the patients was stained with di-hydro-rhodamine and reactive oxygen species production in the phagocytes was measured.

Results: A total of 14 cases were studied out of which 8 and 6 had aspergillosis and mucormycosis respectively. 5 patients, all of whom belonged to the aspergillosis group, showed decreased phagocyte oxidative burst function quantified using Neutrophil Oxidation Index.

Conclusions: Invasive aspergillosis in a patient may point towards an intrinsic derangement in phagocyte oxidative function. Evaluation of phagocytic function should be done in all the cases of invasive aspergillosis.

Keywords: Invasive Aspergillosis; Phagocytic Function; Neutrophil Oxidative Index; Chronic Granulomatous Disease; Innate Immunity

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Citation

Citation: Kapil Sikka., et al. “Phagocyte Oxidative Dysfunction in Invasive Sino Nasal Aspergillosis".Acta Scientific Otolaryngology 7.7 (2025): 28-31.

Copyright

Copyright: © 2025 Kapil Sikka., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.