Vera Miranda¹*, Miguel Lopes¹, Luciana Rodrigues¹, Paulo Gonçalves¹, Tiago Soares Santos^1,2

¹ENT Department, Unidade Local de Saúde Entre o Douro e Vouga, Portugal
²Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal

*Corresponding Author: Vera Miranda, ENT Department, Unidade Local de Saúde Entre o Douro e Vouga, Portugal.

Received: December 31, 2024; Published: January 16, 2025

Abstract

Background: Chronic rhinosinusitis (CRS) is a clinical syndrome, characterized by persistent symptomatic inflammation of the nose and paranasal sinus mucosa for more than 12 weeks. Based on infiltration type, CRS can be classified as eosinophilic or non-eosinophilic. Recent evidence has shown that blood eosinophil count is a reasonable biomarker to predict eosinophilic CRS, which appear to be associated with severe and refractory disease. One of the validated tools to assess symptoms and quality of life in CRS patients is the SNOT-22 questionnaire. The purpose of this study was to evaluate if there was a correlation between blood eosinophil counts with clinical severity in CRS patients.

Material and Methods: We conducted a prospective study from September 2022 to January 2024. Eligible subjects were adults over 18 years old with CRS diagnosed according to EPOS2020 without medical therapy (antibiotics, systemic or topical corticosteroids, or other immunomodulatory drugs) for at least two months prior to medical appointment. Blood eosinophil counts and SNOT-22 questionnaire were requested for all included patients before starting medical therapy.

Results: Seventy-nine CRS patients (34 females, 45 males, mean age 49 years old) were included in this study. There was a positive correlation between blood eosinophil count and SNOT-22 score (r=0.123), without significant association (p=0.281).

Conclusion: Higher blood eosinophil counts showed a positive trend with increased symptom severity in CRS patients. Although not statistically significant, these findings highlight the potential clinical value of eosinophil- based stratification.

Keywords:Symptom Severity; Sino-Nasal Outcome Test; Quality of Life; Eosinophils; Chronic Rhinosinusitis

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Citation

Citation: Vera Miranda., et al. “Do High Blood Eosinophil Levels Predict Worse Quality of Life in Chronic Rhinosinusitis Patients?".Acta Scientific Otolaryngology 7.2 (2025): 03-07.

Copyright

Copyright: © 2025 Vera Miranda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.