Sudden Sensonural Hearing Loss in Different Treatment Approaches
Eman Boshwisha1, Agila Albarasi2*, Naema Muftah M Almagassbi3, Khaled G Hasen4, Fatma Yousuf M Ziuo5
1Department of Otolaryngology, Faculty of Medicine, Elmarge University, Libya
2Department of Otolaryngology, Faculty of Medicine, Benghazi University, Libya
3Department of Otorhinolaryngology, Faculty of Medicine, Misurata University, Libya
4Department of Otolaryngology, Faculty of Medicine, Omer AL Mukhtar University, Libya
5Department of Family and Community Medicine, Faculty of Medicine, Benghazi University, Libya
*Corresponding Author: Agila Albarasi, Associate Professor, Department of Otolaryngology, Faculty of Medicine, Benghazi University, Libya.
Received:
May 18, 2024; Published: June 28, 2024
Abstract
Background: Idiopathic sudden sensonural hearing loss (ISSHL), a condition characterized by hearing loss exceeding 30 dB HL in three consecutive audiometric frequencies within three days or less. This study aimed to evaluate the effectiveness of systemic, intratympanic, and combination steroid administration in the treatment of idiopathic sudden sensonural hearing loss (ISSHL).
Subjects and Method: A prospective clinical trial was conducted on 60 patients with severe (SSNHL) between January 2014 and April 2017. The patients were divided into three groups: oral steroid group, intratympanic steroid group, and mixed treatment group. IT injection by topical anaesthesia and dexamethasone injection twice a week for 2 weeks. The oral steroid group received 60 mg of prednisolone tapered over two weeks. The mean hearing levels were expressed as the average of hearing thresholds at 0.5, 1, 2, and 3 kHz (4-tone average). Complete recovery was defined as >30 dB and final hearing >25 dB, partial recovery >15 dB, slight improvement was >15 dB, and no improvement was <15 dB.
Results: A study of 60 cases with a 1:1.4 male-to-female ratio found that 40% of the participants had a 20-45 db hearing rate before the intratympanic injection. The remaining 60% had a 46-70 db rate, while 15% had a >70-90 db rate. The rate of hearing improvement was statistically significant before and after treatment. The third group (oral steriod and intratympanic steroid injection) showed greater improvement, with a mean of 28.360 + 12.753. However, no statistical significance was found between the three treatment modalities, as the P value >0.005.
Conclusion: The study found no significant differences in outcomes between oral and IT as a mixed treatments or apart for managing hearing loss, suggesting they can be equally effective. Further research is needed to understand long-term effects.
Keywords: Sudden; Sensonural; Hearing; Intratympanic Injection; Prednisolone
References
- de Kleyn. “Sudden complete or partial loss of function of the octavus-system in apparently normal persons”. Acta Otolaryngology 5-6 (1944): 407-429.
- “Disorders, National Institute on Deafness and Other Communication (NIDCD)”. NIH Sudden dea, (2016).
- I Neeraj N Mathur, MBBS, MS, DNB, MAMS, FAMS Professor and Head, Department of ENT, Amrita Hospital and Amrita Institute of Medical Sciences, Faridabad. “Sudden Hearing Loss”. Medscape, (2021).
- S H Kim., et al. “A trend in sudden sensorineural hearing loss: data from a population-based study”. Audiology and Neurotology 6 (2018): 311-316.
- F T Shaia and J L Sheehy. “Sudden sensori-neural hearing impairment: a report of 1,220 cases”. Laryngoscope3 (1976): 389-398.
- SA Sara., et al. “Bilateral sudden sensorineural hearing loss”. The Journal of Laryngology and Otology S1 (2014): S8--S15.
- G J Gianoli and J C Li. “Transtympanic steroids for treatment of sudden hearing loss”. Otolaryngology Neck Surgery 3 (2001): 142-146.
- N Berjis., et al. “Intratympanic dexamethasone injection vs methylprednisolone for the treatment of refractory sudden sensorineural hearing loss”. Advanced Biomedical Research 5 (2016).
- KH Lee., et al. “Is Intratympanic Dexamathasone Injection Effective for the Treatment of Idiopathic Sudden Sensorineural Hearing Loss?”. Journal of Audiology and Otology 3 (2015): 154-158.
- T Yang., et al. “Intratympanic vs systemic use of steroids as first-line treatment for sudden hearing loss: A meta-analysis of randomized, controlled trials.”. Journal of Otology 3 (2021): 165-177.
- D M Barrs., et al. “Intratympanic steroid injections for intractable Meniere’s disease”. Laryngoscope12 (2001): 2100-2104.
- H Silverstein., et al. “Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report)”. Ear, nose and Throat Journal 8 (1996): 468-488.
- R Filipo., et al. “Intratympanic steroid therapy in moderate sudden hearing loss: a randomized, triple-blind, placebo-controlled trial”. Laryngoscope3 (2013): 774-778.
- LS Laura Bontempo., et al. “Clinical Practice Guideline: Sudden Hearing Loss (Update)”. American Academy of Otolaryngology-Head and Neck (2019).
- I S Moon., et al. “Intratympanic Dexamethasone Is an Effective Method as a Salvage Treatment in Refractory Sudden Hearing Loss”. Otology and Neurotology 32 (2011): 1432-1436.
- HP Wu., et al. “Intratympanic steroid injections as a salvage treatment for sudden sensorineural hearing loss: a randomized, double-blind, placebo-controlled study”. Otology and Neurotology 5 (2011): 774-779.
- JH Hara., et al. “Oral and intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss”. Laryngoscope Investigation on Otolaryngology 2 (2018): 73-77.
- R J Stachler., et al. “Clinical practice guideline: sudden hearing loss”. Otolaryngology–Head and Neck Surgery 3 (2012): S1-35.
- TH Alexander., et al. “Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL”. Otology and Neurotology 8 (2015): 1321-1327.
- SW Yeo., et al. “Hearing outcome of sudden sensorineural hearing loss: long-term follow-up.”. Otolaryngology–Head and Neck Surgery 2 (2007): 221-224.
- G Plaza and C Herráiz. “Intratympanic steroids for treatment of sudden hearing loss after failure of intravenous therapy”. Otolaryngology–Head and Neck Surgery 1 (2007): 74-78.
- SD Rauch. “Intratympanic steroids for sensorineural hearing loss”. Otolaryngologic Clinics of North America 5 (2004): 1061-1074.
- J Huang., et al. “Differences in hearing recovery following intratympanic alone or intravenous dexamethasone with rescue intratympanic steroids for sudden sensorineural hearing loss: a randomised trial”. Clinical Otolaryngology 3 (2021): 546-551.
- Q Qiang., et al. “A comparison between systemic and intratympanic steroid therapies as initial therapy for idiopathic sudden sensorineural hearing loss: a meta-analysis”. Acta Otolaryngology 6 (2017): 598-605.
- SH Kim., et al. “Comparison of steroid administration methods in patients with idiopathic sudden sensorineural hearing loss: a retrospective observational study”. Clinical Otolaryngology 3 (2015): 183-190.
- SD Rauch., et al. “Oral vs Intratympanic Corticosteroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Trial”. JAMA20 (2011): 2071-2079.
Citation
Copyright