Majd Ammar* and Ahmad Mostafa

Department of ENT Head and Neck Surgery, Almowassat University Hospital, Damascus, Syria

*Corresponding Author: Majd Ammar, Department of ENT Head and Neck Surgery, Almowassat University Hospital, Damascus, Syria.

Received: February 25, 2024; Published: April 06, 2024

Abstract

Background and Objectives: Oral cancers considered one of the most common head and neck cancers; they are associated with high rates of morality especially during advanced stages. Early detection and proper management obviously improve survival rates and decrease mortality. On one-hand cancers depends on anaerobic glycolysis to produce the important energy needed for mitosis and biogenesis, on the other hand lactate dehydrogenase enzyme plays a major role in anaerobic glycolysis, for these reasons this research aims to study the effectiveness of using the saliva as a diagnostic tool for oral cancers by estimation of lactate dehydrogenase.

Methods: This prospective study involved 60 cases admitted to Al-Mowassat university hospital and AlBayrouni hospital subdivided into three groups (Oral cancers, oral benign lesions, and control group). The saliva samples collected in the morning and the patients prohibited from consuming water or food for at least 12 hours before sampling to prevent food and water interference in salivary enzyme levels.

Results: An elevation in salivary LDH noticed in oral cancers group compared to benign and control groups, it also noticed between the three grades groups but no correlation has improved between salivary LDH and tumors size.

Conclusion: The increase in salivary LDH levels could be used as a diagnostic tool, furthermore, the levels significantly correlated with the histological grade of OSCC.

Keywords: Lactate Dehydrogenase Enzyme; Saliva; Oral Cancers; Anaerobic Glycolysis

References

1. Nagler RM., et al. “New insights into salivary lactate dehydrogenase of human subjects”. Journal of Laboratory and Clinical Medicine 137 (2001): 363-369.
2. Honarmand M., et al. “Salivary Lactate Dehydrogenase, C - reactive protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma”. International Journal of Cancer Management 3 (2021): e108344.
3. Swetha Acharya., et al. “Prognostic Significance of Preoperative Salivary and Serum Lactate Dehydrogenase in Oral Squamous Cell Carcinoma Patients". Acta Scientific Cancer Biology8 (2018): 02-10.
4. Ferlay J., et al. “GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11”. Lyon, France: International Agency for Research on Cancer; (2013).
5. Lokesh K., et al. “Salivary Lactate Dehydrogenase (LDH) - A Novel Technique in Oral Cancer Detection and Diagnosis”. Journal of Clinical and Diagnostic Research2 (2016): ZC34-ZC37.
6. Ping Miao., et al. “Lactate Dehydrogenase A in Cancer: A Promising Target for Diagnosis and Therapy”. International Union of Biochemistry and Molecular Biology11 (2013): 904-910.
7. Potter M., et al. “The Warburg effect: 80 years on”. Biochemical Society Transactions 5 (2016): 1499-1505.
8. Saluja TS., et al. “ Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma. An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype”. Tumour Biology4 (2016): 56095620.
9. Shrikant Patel and Rashmi Metgud. “Estimation of salivary lactate dehydrogenase in oral leukoplakia and oral squamous cell carcinoma: A biochemical study”. Journal of Cancer Research and Therapeutics1 (2015).
10. Suchorolski MT., et al. “Warburg and Crabtree effects in premalignant Barrett’s esophagus cell lines with active mitochondria”. PloS One2 (2013): e56884.
11. Wong DT. “Salivary diagnostics powered by nanotechnologies, proteomics and genomics”. Journal of the American Dental Association 137 (2006): 313-321.
12. Xiaoqian Wang., et al. “Salivary Biomarkers in Cancer Detection”. Medical Oncology1 (2017): 7.

Citation

Citation: Majd Ammar and Ahmad Mostafa. “The Diagnostic Role of Salivary Lactate Dehydrogenase in Oral Squamous Cell Carcinoma". Acta Scientific Otolaryngology 6.5 (2024): 03-07.

Copyright

Copyright: © 2024 Majd Ammar and Ahmad Mostafa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.