Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 6 Issue 5

The Diagnostic Role of Salivary Lactate Dehydrogenase in Oral Squamous Cell Carcinoma

Majd Ammar* and Ahmad Mostafa

Department of ENT Head and Neck Surgery, Almowassat University Hospital, Damascus, Syria

*Corresponding Author: Majd Ammar, Department of ENT Head and Neck Surgery, Almowassat University Hospital, Damascus, Syria.

Received: February 25, 2024; Published: April 06, 2024


Background and Objectives: Oral cancers considered one of the most common head and neck cancers; they are associated with high rates of morality especially during advanced stages. Early detection and proper management obviously improve survival rates and decrease mortality. On one-hand cancers depends on anaerobic glycolysis to produce the important energy needed for mitosis and biogenesis, on the other hand lactate dehydrogenase enzyme plays a major role in anaerobic glycolysis, for these reasons this research aims to study the effectiveness of using the saliva as a diagnostic tool for oral cancers by estimation of lactate dehydrogenase.

Methods: This prospective study involved 60 cases admitted to Al-Mowassat university hospital and AlBayrouni hospital subdivided into three groups (Oral cancers, oral benign lesions, and control group). The saliva samples collected in the morning and the patients prohibited from consuming water or food for at least 12 hours before sampling to prevent food and water interference in salivary enzyme levels.

Results: An elevation in salivary LDH noticed in oral cancers group compared to benign and control groups, it also noticed between the three grades groups but no correlation has improved between salivary LDH and tumors size.

Conclusion: The increase in salivary LDH levels could be used as a diagnostic tool, furthermore, the levels significantly correlated with the histological grade of OSCC.

Keywords: Lactate Dehydrogenase Enzyme; Saliva; Oral Cancers; Anaerobic Glycolysis


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Citation: Majd Ammar and Ahmad Mostafa. “The Diagnostic Role of Salivary Lactate Dehydrogenase in Oral Squamous Cell Carcinoma". Acta Scientific Otolaryngology 6.5 (2024): 03-07.


Copyright: © 2024 Majd Ammar and Ahmad Mostafa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate34%
Acceptance to publication20-30 days
Impact Factor0.871

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