Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Case Report Volume 5 Issue 7

From Muffled Hearing to Facial Nerve Palsy: A Case Report and Literature Review of Middle and Inner Ear Granulomatosis with Polyangiitis

Anas Eldahshan*

ENT Department, The Rotherham NHS Foundation Trust, England, UK

*Corresponding Author: Anas Eldahshan, ENT Department, The Rotherham NHS Foundation Trust, England, UK.

Received: April 21, 2023; Published: June 23, 2023


This case report discusses a patient who initially presented with severe otitis media and hearing loss, which later led to a diagnosis of granulomatosis with polyangiitis (GPA). Despite only affecting the patient's ear and facial nerve, GPA is an autoimmune disease that can impact several organs in the body. Laboratory tests revealed elevated levels of PR3 and positive C-ANCA. The patient received treatment with a combination of corticosteroids and immunosuppressants, resulting in the resolution of otitis media and facial nerve palsy, while preserving their hearing. This case emphasizes the significance of considering GPA as a possible diagnosis in patients with sudden hearing loss and otitis media who may also experience facial nerve palsy, particularly in those with high C-ANCA levels.

 Keywords: Granulomatosis with Polyangiitis; Cytoplasmic Anti-neutrophil Cytoplasmic Antibodies; Otitis Media; Hearing Loss


  1. Kühn D., et al. “Manifestation of Granulomatosis with Polyangiitis in Head and Neck”. Clinical and Experimental Rheumatology 2 (2018): 78-84.
  2. Djerić D., et al. “Otitis media with effusion as an initial manifestation of granulomatosis with polyangiitis”. SAGE Open Medical Case Reports 9 (2021): 2050313.
  3. Wawrzecka A., et al. “Granulomatosis with polyangiitis with bilateral facial palsy and severe mixed hearing loss”. Case Reports in Otolaryngology 2016 (2016): 5206170.
  4. Kukushev G., et al. “Two clinical cases of granulomatosis with polyangiitis with isolated otitis media and mastoiditis”. Reumatologia 55 (2017): 256-260.
  5. Wojciechowska J and KręCicki T. “Clinical characteristics of patients with granulomatosis with polyangiitis and microscopic polyangiitis in ent practice: a comparative analysis”. Acta Otorhinolaryngologica Italica 38 (2018): 517-527.
  6. Goh KY., et al. “Intractable chronic otitis media, rhinosinusitis and facial palsy: a case of active granulomatosis with polyangiitis”. BMJ Case Reports 13 (2020): e233685.
  7. Carnevale C., et al. “Head and Neck Manifestations of Granulomatosis with Polyangiitis: A retrospective analysis of 19 patients and review of the literature”. International Archives of Otorhinolaryngology 23 (2019): 165-171.
  8. Andrada-Elena M., et al. “Wegener’s granulomatosis with orbital involvement: case report and literature review”. Romanian Journal of Ophthalmology 65 (2021): 93-97.
  9. Trandafir CM., et al. “Granulomatosis with Polyangiitis (GPA)-A Multidisciplinary Approach of a Case Report”. Medicina 58 (2022): 1837.
  10. Amiraraghi N., et al. “Primary otological manifestations of granulomatosis with polyangiitis: a case series”. The Journal of Laryngology and Otology 129 (2015): 179-182.


Citation: Anas Eldahshan. “From Muffled Hearing to Facial Nerve Palsy: A Case Report and Literature Review of Middle and Inner Ear Granulomatosis with Polyangiitis".Acta Scientific Otolaryngology 5.7 (2023): 32-35.


Copyright: © 2023 Anas Eldahshan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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