Md Masud Rana¹*, Md Shaheen Reza², Md Tanuwar Islam Chowdhury³, Md Mostakim Maoya⁴, Md Asaduzzaman⁵, Munshi Akid Mostofa⁶, Md Abu Sayed⁷ and Mohammad Ali Arafat⁸

¹Assistant Professor, Department of Urology, Bangladesh Medical College and Hospital, Dhaka, Bangladesh
²Assistant Professor, Department of Urology, Sheikh Hasina Medical College and Hospital, Tangail, Bangladesh
³Assistant Registrar, Department of Urology, Shaheed Suhrawardy Medical College and Hospital, Dhaka, Bangladesh
⁴Specialist, Department of Urology, Evercare Hospital, Dhaka, Bangladesh
⁵Assistant Registrar, Department of Urology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh
⁶Assistant Registrar, Department of Urology, National Institute of Cancer Research and Hospital, Dhaka, Bangladesh
⁷Assistant Professor, Department of Urology, Kidney Foundation Hospital and Research Institute, Dhaka, Bangladesh
⁸Junior Consultant, Department of Urology, Bangladesh Medical College and Hospital, Dhaka, Bangladesh

*Corresponding Author: Md Masud Rana, Assistant Professor, Department of Urology, Bangladesh Medical College and Hospital, Dhaka, Bangladesh.

Received: March 13, 2023; Published: March 27, 2023

Abstract

Background: On patient quality of life, stent-associated symptoms can have a significant impact. Related to indwelling ureteral stents, hematuria, urgency, frequency, dysuria, and both bladder and flank pain are the most prevalent symptoms. Among them low back pain and irritative lower urinary tract symptoms and are more frequent. Because of its importance stent is being kept in situ with varieties of medication despite the stent related symptoms. To relief these symptoms like Tamsulosin, Solifenacin, Alphazosin etc., several alpha-adrenergic blocker and antimuscarinic drugs are used. Tamsulosin and Solifenacin both are not costly as use daily single dose. So combination of Tamsulosin and Solifenacin cost effective and may act as a reliever of stent related symptoms also.

Objectives: To evaluate the effect of Tamsulosin and Solifenacin in relieving DJ stent related symptoms.

Methodology: This prospective quassi experimental study was performed from November 2016 to April 2018. Patients who placed DJ stent after endoscopic stone management in the Department of Urology, Dhaka Medical College and Hospital recruited as study population. A total of 47 patients who were stented following ureteroscopic lithotripsy were included, allocated purposively into two groups. Group A (Tamsulosin) 24 and and Group B (Solifenacin) 23 patients were selected by purposive sampling technique according to inclusion and exclusion criteria for the study.

Results: In the current study, the mean age of the patients was 39.08(±8.798) and 38.84(±11.063) in group A and group B respectively. Male patients were leading in both groups. Total IPSS, irritative subgroup of IPSS, QOL score and VAS on T1 assessment done on 3^rd postoperative day were evaluated in both the groups and no statistically significant difference (P > 0.05) in all scores were noted. In the study, the mean value of total IPSS, irritative subgroup of IPSS and QOLS was significantly improved in group-A in comparison to that of group B, 6.28, 3.2, 2.4 and 7.40, 4.04, 2.8 respectively (P < 0.05). The intensity of stent-related flank pain in group A was significantly lower than in the group B (2.36 compared with 2.64, P < 0.05).

Conclusion: This study was aimed to compare the outcomes of Tamsulosin and Solifenacin to relieve stent related symptoms. We conclude that Tamsulosin is more effective than Solifenacin in this regard.

 Keywords: Endourological Procedures; Double-J Ureteral Stent; Tamsulosin; Solifenacin

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Citation

Citation: Md Masud Rana., et al. “Comparative Study to Evaluate the Effect of Tamsulosin and Solifenacin on DJ Stent Related Symptoms".Acta Scientific Otolaryngology 5.4 (2023): 37-43.

Copyright

Copyright: © 2023 Md Masud Rana., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.