Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Case Report Volume 4 Issue 12

Non Hodgkin Lymphoma Presenting as Unilateral Nasal Mass: A Diagnosing Challange

Ahmed Aseem Naseem1*, Rashmi Nambiar2, Sumit Sharma3, Sanyukta Chakravarty2, Mahesh Mishra2, Ruchika Singh4 and Suvarna Sharma5

1Assistant Professor, Mayo Institute of Medical Sciences, Barabanki, Utter Pradesh, India
2Junior Resident Second Year, Mayo Institute of Medical Sciences, Barabanki, Utter Pradesh, India
3Professor and Head, Department of E.N.T., Mayo Institute of Medical Sciences, Barabanki, Utter Pradesh, India
4Associate Professor, Department of Radiology, Mayo Institute of Medical Sciences, Barabanki, Utter Pradesh, India
5Intern, KMC Manipal, India

*Corresponding Author: Ahmed Aseem Naseem, Assistant Professor, Mayo Institute of Medical Sciences, Barabanki, Utter Pradesh, India.

Received: August 18, 2022; Published: November 21, 2022

Abstract

Background: NHL is comprised in a group of tumors arising from the lymphoreticular cell system. The causative factors for this condition are infective etiologies like EBV, HT cell leukemia virus h. pylori, HHV, hepatitis c and HIV and other causes being the chemoradiation therapy and certain chemical exposure like- herbicides etc. certain genetic disorders are also known to show association with NHL like SLE, klinefelter syndrome, ataxia etc. NHL in nose and PNS as primary lesion is a very rare entity.

Objective: The purpose of our study is to throw light on the significance of complete history, examination and significance of immunohistochemistry over CT and histopathology in patients presenting with nasal mass to diagnose such a rare entity which is easily missed.

Method: We report a case of 60 year male with right facial pain and right nasal obstruction who was diagnosed by immunohistochemistry.

Result: Computed tomography and histopathology revealed inflammatory pathology and polyp. But immunohistochemistry was consistent with non Hodgkin lymphoma- diffuse large B cell lymphoma.

Conclusion: With this study we emphasise the role of IHC as a routine investigation in all sinonasal masses for early diagnosing and managing such rare entity.

Keywords: Non-Hodgkin; Nasal Polyposis; B-Cell; Human T Cell; Paranasal Sinuses; Ebstein Bar Virus

References

  1. Mitsuyasu RT. “Non-AIDS defining malignancies in HIV”. Top HIV Medicine 16 (2008): 117-121.
  2. Wang J., et al. “Primary Tcell rich B-cell lymphoma of the ethmoid sinus. A case report with 5 years of follow-up”. Archives of Pathology and Laboratory Medicine 124 (2000): 1213-1216.
  3. Piatelli A., et al. “Primary non-Hodgkin’s lymphoma of the mandible: A case report”. Journal of Oral and Maxillofacial Surgery 55 (1997): 1162-1166.
  4. Longsdon M., et al. “Lymphoma of the nasal cavity and paranasal sinuses. Improved out- come and altered prognostic factors with combined modality therapy”. Cancer 80 (1997): 477-488.
  5. Frierson H., et al. “Immunophenotype analysis of sinonasal non-Hodgkin’s lymphoma”. Human Pathology 20 (1989): 636-642.
  6. Kanavaros P., et al. “Nasal T-cell lymphoma: a clinicopathologic entity associated with peculiar phenotype and with Epstein-Barr virus”. Blood 81 (1993): 2688-2695.
  7. Ferry J., et al. “Nasal lymphoma: a clinicopathologic study with immunophenotypic and genotypic analysis”. The American Journal of Surgical Pathology 15 (1991): 268-279.
  8. Hatta C., et al. “Non-Hodgkin’s malignant lymphoma of the sinonasal tract – treatment outcome for 53 patients according to REAL classification”. Auris Nasus Larynx 28 (2001): 55-60.
  9. Bumpous J., et al. “Non-Hodgkin’s lymphomas of the nose and the paranasal sinuses in the paediatric population”. Annals of Otology, Rhinology and Laryngology 103 (1994): 294-300.
  10. Quraishi M., et al. “Non Hodgkin’s lymphoma of the sinonasal tract”. Laryngoscope 110 (2000): 1489-1492.
  11. Yamanaka N., et al. “Non-Hodgkin’s lymphoma of Waldayer’s ring and nasal cavity, clinical and immunological aspects”. Cancer 56 (1985): 768-776.
  12. Chan J., et al. “Immunophenotypic analysis of non-Hodgkin’s lymphomas in Chinese: a study of 75 cases in Hong Kong”. Pathology 18 (1986): 419-425.
  13. Abbondanzo S and Wenig B. “Non-Hodgkin’s lymphoma of the sinonasal tract”. Cancer 75 (1995): 1281-1291.
  14. Vidal R., et al. “Sinonasal malignant lymphomas: a distinct clinicopathological category”. Annals of Otology, Rhinology and Laryngology 108 (1999): 411-419.
  15. Conlan MG., et al. “Bone marrow involvement by non-Hodgkin's lymphoma: the clinical significance of morphologic discordance between the lymph node and bone marrow. Nebraska Lymphoma Study Group”. Journal of Clinical Oncology 7 (1990): 1163-1172.
  16. Graus F., et al. “Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas”. Blood21 (2014): 3230-3238.

Citation

Citation: Ahmed Aseem Naseem., et al. “Non Hodgkin Lymphoma Presenting as Unilateral Nasal Mass: A Diagnosing Challange".Acta Scientific Otolaryngology 4.12 (2022): 20-23.

Copyright

Copyright: © 2022 Ahmed Aseem Naseem., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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