Poramate Pitak-Arnnop* and Andreas Neff

Department of Oral and Craniomaxillofacial Plastic Surgery, UKGM GmbH, University Hospital Marburg, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany

*Corresponding Author: Poramate Pitak-Arnnop, Department of Oral and Craniomaxillofacial Plastic Surgery, UKGM GmbH, University Hospital Marburg, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.

Received: July 25, 2022; Published: August 01, 2022

Abstract

Over the past 1.5 years vaccination has become one of effective measures to combat the novel Coronavirus disease 2019 (COVID-19). Several adverse reactions arising from COVID-19 vaccines have been reported in the literature. These can be categorised into systemic and local adverse reactions – the former often presents with fever, fatigue, and headache, while the latter is frequently associated with pain, erythema, and swelling at the injection site. A recent meta-analysis demonstrated that different relative risks (RR) of systemic reactions depended upon the vaccine type, i.e., 1.13 (95% confidence interval [CI], 0.79 to 1.61), 1.53 (95% CI, 1.08 to 2.16), 1.58 (95% CI, 1.13 to 1.90), 0.72 (95% CI, 0.34 to 1.55), and 1.62 (95% CI, 1.39 to 1.89) for inactivated virus, mRNA, vector, DNA, and protein subunit vaccines, respectively. The RR of local adverse events following immunization with inactivated vaccine, mRNA vaccine, vector vaccine, DNA, and protein subunit vaccine was 2.18 (95% CI, 1.32 to 3.59), 4.96 (95% CI, 4.02 to 6.11), 1.48 (95% CI, 0.88 to 2.50), 1.04 (95% CI, 0.12 to 8.75), and 4.09 (95% CI, 2.63 to 6.35), respectively. However, the vaccine type was not a significant predictor of systemic and local adverse events. In other words, the vaccine safety is “relatively” comparable, in spite of the fact that mRNA vaccines tend to be related to higher adverse effects [1].

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Citation

Citation: Poramate Pitak-Arnnop and Andreas Neff. “Delayed-type Hypersensitivity Reaction to Facial Dermal Fillers After COVID-19 Vaccination".Acta Scientific Otolaryngology 4.9 (2022): 01-03.

Copyright

Copyright: © 2022 Poramate Pitak-Arnnop and Andreas Neff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.