Nezar Yaseen Albar¹, Ayman Khater², Naif Yaseen Albar³* and Ibrahim Galal⁴

¹Department of Internal Medicine, Endocrinology, Nostalgia Clinic, Jeddah, Saudi Arabia
²Department of Pulmonology, Samir Abbas Hospital, Jeddah, Saudi Arabia
³Department of Otorhinolaryngology, Head and Neck Surgery, King Abdulaziz University College of Medicine. Rabigh, Jeddah, Saudi Arabia
⁴Department of ICU, Samir Abbas Hospital, Jeddah, Saudi Arabia

*Corresponding Author: Naif Yaseen Albar, Department of Otorhinolaryngology, Head and Neck Surgery, King Abdulaziz University College of Medicine. Rabigh, Jeddah, Saudi Arabia.

Received: June 24, 2022; Published: July 21, 2022

Abstract

Background: COVID-19 is a pandemic with no specific therapeutic agents yet approved. Presenting our experience with the clinical efficacy of convalescent plasma (CP) therapy in a critically ill non-responsive COVID-19 patient.

Case Summary: A diabetic hypertensive 70-year-old patient presented to ER with dyspnea, SO₂ 90% RA and low-grade fever along with COVID-19 positive swab by PCR, and bilateral fine basal crackles, chest CT shows ground glass opacities (GGOs) in the right upper Lobe, CRP 3 mg/dl and IL-6 18 pg/ml. After initial 3 days stay in ICU, condition improved on oral Favipiravir, Azithromycin and Oseltamivir, and IV Ceftriaxone and IM dexamethasone. One week after initial discharge from ICU, condition gradually deteriorated with no response to Tocilizumab administration then pulse therapy methyl prednisolone and Remdesivir. Patient readmitted to ICU and treatment with CP was started with 2 units derived from a recently recovered single donor with plasma SARS-CoV-2 anti-S1/S2 IgG antibodies of 20 AU/mL. After initial improvement patient was discharged from ICU, but then condition deteriorated again with dramatic rise of IL-6. After extra 2 doses of Convalescent Plasma but this time derived from another donor with higher neutralizing activity as inferred by a higher plasma anti-S1/S2 IgG antibodies level of 39 AU/mL, patient condition improved dramatically with SO₂ 90-92% on RA sitting position. He was then finally discharged on home medication and domiciliary oxygen during effort and sleep.

Discussion: This case supports the role of CP with sufficient neutralizing capacity, as an effective treatment for critically ill COVID-19 patients.

Keywords: COVID-19; SARS-CoV-2; Convalescent Plasma (CP)

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Citation

Citation: Nezar Yaseen Albar., et al. “Effectiveness of Convalescent Plasma Therapy in Critically Ill COVID-19 Patient: A Case Report".Acta Scientific Otolaryngology 4.8 (2022): 27-32.

Copyright

Copyright: © 2022 Nezar Yaseen Albar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.