Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 4 Issue 8

Autologous Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients

Brajpal Tyagi* and Manika Teotia

Department to ENT, Harsh ENT Hospital, India

*Corresponding Author: Brajpal Tyagi, Department to ENT, Harsh ENT Hospital, India.

Received: July 03, 2022; Published: July 21, 2022


Background: MSCs exhibit remarkable self-renewal capacity and the ability to differentiate not only into osteoblasts but even also into neurons in vitro and in vivo and therefore, MSCs have been successfully used in otorhinolaryngology.

Methods: Autologous human bone marrow mononuclear fraction (BMMF) was harvested and given to subjects with moderate to severe sensorineural hearing loss. The aim was to determine if bone marrow mononuclear fraction (BMMF) infusion causes any improvement in hearing.

Result: Out of 30 subjects 22 subjects did not showed significant improvement. 8 patients however showed significant improvement in PTA as well as clinically. The average improvement of 8 patients was calculated to be 15 db after 1 BM instillation. 2 patients also showed clinical improvement in their tinnitus which was an additional finding and needs to be evaluated further.

Conclusion: This review suggests that BMSCs are capable to migrate and survive into the cochlear tissues which them suitable to be used in transplantation as a strategy for regenerating inner ear and treatment of SNHL.

Keywords: Stem Cell; Sensorineural Hearing Loss; Neurons


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Citation: Brajpal Tyagi and Manika Teotia. “Autologous Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients".Acta Scientific Otolaryngology 4.8 (2022): 20-23.


Copyright: © 2022 Brajpal Tyagi and Manika Teotia. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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