Autologous Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
Brajpal Tyagi* and Manika Teotia
Department to ENT, Harsh ENT Hospital, India
*Corresponding Author: Brajpal Tyagi, Department to ENT, Harsh ENT Hospital, India.
July 03, 2022; Published: July 21, 2022
Background: MSCs exhibit remarkable self-renewal capacity and the ability to differentiate not only into osteoblasts but even also into neurons in vitro and in vivo and therefore, MSCs have been successfully used in otorhinolaryngology.
Methods: Autologous human bone marrow mononuclear fraction (BMMF) was harvested and given to subjects with moderate to severe sensorineural hearing loss. The aim was to determine if bone marrow mononuclear fraction (BMMF) infusion causes any improvement in hearing.
Result: Out of 30 subjects 22 subjects did not showed significant improvement. 8 patients however showed significant improvement in PTA as well as clinically. The average improvement of 8 patients was calculated to be 15 db after 1 BM instillation. 2 patients also showed clinical improvement in their tinnitus which was an additional finding and needs to be evaluated further.
Conclusion: This review suggests that BMSCs are capable to migrate and survive into the cochlear tissues which them suitable to be used in transplantation as a strategy for regenerating inner ear and treatment of SNHL.
Keywords: Stem Cell; Sensorineural Hearing Loss; Neurons
- Olusanya BO., et al. “Hearing loss: rising prevalence and impact”. Bulletin of the World Health Organization 10 (2019): 646-646A.
- Graydon K., et al. “Global burden of hearing impairment and ear disease”. Journal of Laryngology and Otology 1 (2019): 18-25.
- Oshima K., et al. “Differential distribution of stem cells in the auditory and vestibular organs of the inner ear”. Journal of the Association for Research in Otolaryngology 1 (2007): 18-31.
- Reya T., et al. “Stem cells, cancer, and cancer stem cells”. Nature 6859 (2001): 105-111.
- Kim SS., et al. “Neural induction with neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain”. Stem Cells9 (2008): 2217-2228.
- Kim J and Hematti P. “Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages”. Experimental Hematology 12 (2009): 1445-1453.
- Phinney DG and Prockop DJ. “Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views”. Stem Cells11 (2007): 2896-2902.
- King SN., et al. “Current applications of mesenchymal stem cells for tissue replacement in otolaryngology-head and neck surgery”. American Journal of Stem Cells 3 (2012): 225-238.
- Prockop DJ and Oh JY. “Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation”. Molecular Therapy1 (2012): 14-20.
- De Girolamo L., et al. “Mesenchymal stem/stromal cells: A new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy”. Current Pharmaceutical Design 13 (2013): 2459-2473.
- Kondo T., et al. “Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3”. Stem Cells5 (2011): 836-846.
- Lang H., et al. “Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: mesenchymal cells and fibrocytes”. The Journal of Comparative Neurology 2 (2006): 187-201.
- Lee JH., et al. “Neural differentiation of bone marrow-derived mesenchymal stem cells: applicability for inner ear therapy”. Korean Journal of Audiology2 (2012): 47-53.
- Domen J., et al. “Bone marrow (hematopoietic) stem cells”. Regenerative Medicine (2006): 13.
- Tyagi BPS and Mamatarani RM. “Platelet Rich Plasma (PRP): A Revolutionary Treatment of Sensorineural Hearing Loss”. Acta Scientific Otolaryngology 4 (2019): 2-5.
- Lee HS., et al. “Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients”. Journal of Audiology and Otology 2 (2018): 105-109.
- Nishida A., et al. “Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina”. Investigative Ophthalmology and Visual Science 41 (2000): 4268-4274.
- Naito Y., et al. “Transplantation of bone marrow stromal cells into the cochlea of chinchillas”. Neuroreport 1 (2004): 1-4.
- Hermann A., et al. “Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells”. Journal of Cell Science 19 (2004): 4411-4422.
- Krabbe C., et al. “Neural transdifferentiation of mesenchymal stem cells - A critical review”. APMIS11-12 (2005): 831-844.
- Caddick J., et al. “Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage”. Glia 8 (2006): 840-849.
- Yang Q., et al. “A simple and efficient method for deriving neurospheres from bone marrow stromal cells”. Biochemical and Biophysical Research Communications 4 (2008): 520-524.
- Radtke C., et al. “Peripheral glial cell differentiation from neurospheres derived from adipose mesenchymal stem cells”. International Journal of Developmental Neuroscience 8 (2009): 817-823.
- “NIH Stem Cell Information Home Page”. In Stem Cell Information (2018).