Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 4 Issue 7

Characteristic Features of Olfactory and Gustatory Dysfunctions of COVID-19 in Japanese Population

Katsuhisa Ikeda*, Kumiko Tanaka, Shinpei Arai, Nanae Yoshii and Ayako Inoshita

Department of Otorhinolaryngology, Juntendo University, Faculty of Medicine, Tokyo, Japan

*Corresponding Author: Katsuhisa Ikeda, Department of Otorhinolaryngology, Juntendo University, Faculty of Medicine, Tokyo, Japan.

Received: May 07, 2022; Published: June 17, 2022

Abstract

Purpose: Chemosensory dysfunctions have been widely known as frequent and early symptoms of COVID-19. However, the underlying mechanisms of gustatory dysfunction associated with COVID-19 remain controversial. We aimed to reveal the dependency of taste impairment on smell function.

Materials and Methods: Olfactory and gustatory functions were subjectively and objectively examined in 54 COVID-19 patients.

Results: There were 5 patients with isolated subjective gustatory dysfunction and 4 patients with continuing smell dysfunction but resumed taste function, implying smell-independent gustatory dysfunction. Two patients with combined subjective dysfunctions showed objective smell dysfunction and normal objective taste function, suggesting a smell-dependent gustatory event. Olfactory and gustatory dysfunctions were subjectively found in 37.0 and 40.7%, respectively. Smell loss was objectively observed in 64.3% over 65 years, which was significantly greater than those (25.6%) of below 65 years. There was a significant difference in the mean open essence score between those under and those over 65 years.

Conclusion: Gustatory dysfunction is induced by both mechanisms of smell-independent and -dependent fashions in COVID-19 infection. The prevalence of olfactory and gustatory dysfunctions in Japanese corresponded to those of the countries with Caucasians rather than East Asians. A significant increase of objective olfactory dysfunction was recognized in the aged patients older than 65 years.

Keywords: COVID-19, olfactory dysfunction, gustatory function, objective test, smell-dependency

References

  1. Lechien JR., et al. “Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study”. European Archives of Otorhinolaryngology 277 (2020): 2251-2261.
  2. von Bartheld CS., et al. “Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A systematic review and meta-analysis reveals significant ethnic differences”. ACS Chemical Neuroscience 11 (2020): 2944-2961.
  3. Mazzatenta AN., et al. “Smell and Taste in Severe CoViD-19: Self-Reported vs. Testing”. Frontiers in Medicine (Lausanne) 7 (2020): 589409.
  4. Vaira LA., et al. “Gustatory dysfunction: a highly specific and smell-independent symptom of COVID-19”. Indian Journal of Otolaryngology and Head and Neck Surgery 30 (2020): 1-3.
  5. Singer-Cornelius T., et al. “Objective gustatory and olfactory dysfunction in COVID-19 patients: a prospective cross-sectional study”. European Archives of Otorhinolaryngology 278 (2021): 3325-3332.
  6. Giacomelli A., et al. “Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: A Cross-sectional Study”. Clinical Infectious Diseases 71 (2020): 889-890.
  7. Vaira LA., et al. “Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study”. Head and Neck 42 (2020): 1560-1569.
  8. Homma H., et al. “Clinical application of a card-type odor identification test to olfactory assessment in Parkinson's disease”. Auris Nasus Larynx 40 (2013): 173-176.
  9. Qiu C., et al. “Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study”. Otolaryngology–Head and Neck Surgery 163 (2020): 714-721.
  10. Moein ST., et al. “Smell dysfunction: a biomarker for COVID-19”. International Forum of Allergy and Rhinology 10 (2020): 944-950.
  11. Hornuss D., et al. “Anosmia in COVID-19 patients”. Clinical Microbiology and Infection 26 (2020): 1426-1427.
  12. Iravani B., et al. “Relationship between odor intensity estimates and COVID-19 prevalence prediction in a Swedish population”. Chemical Senses (2020): bjaa034.
  13. Gozen ED., et al. “Evaluation of Olfactory Function With Objective Tests in COVID-19-Positive Patients: A Cross-Sectional Study”. Ear Nose, Throat Journal 100 (2021): 169S-173S.
  14. Vaira LA., et al. “Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases”. Head and Neck 42 (2020): 1252-1258.
  15. Agyeman AA., et al. “Smell and taste dysfunction in patients with COVID-19: A systematic review and meta-analysis”. Mayo Clinic Proceedings 95 (2020): 1621-1631.
  16. Hannum ME., et al. “Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19-positive patients compared to subjective methods: a systematic review and meta-analysis”. Chemical Senses 45 (2020): 865-874.
  17. Passarelli PC., et al. “Taste and smell as chemosensory dysfunctions in COVID-19 infection”. American Journal of Dentistry 33 (2020): 135-137.
  18. Tong JY., et al. “The prevalence of olfactory and gustatory dysfunction in covid-19 patients: a systematic review and meta-analysis”. Otolaryngology–Head and Neck Surgery 163 (2020): 3-11.
  19. Doty RL., et al. “Smell identification ability: changes with age”. Science 226 (1984): 1441-1443.
  20. Brechbuhl J., et al. “Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms”. Communications Biology 4 (2021): 880.
  21. Bilinska K., et al. “Expression of the SARS-CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium: identification of cell types and trends with age”. ACS Chemical Neuroscience 11 (2020): 1555-1562.

Citation

Citation: Katsuhisa Ikeda., et al. “Characteristic Features of Olfactory and Gustatory Dysfunctions of COVID-19 in Japanese Population".Acta Scientific Otolaryngology 4.7 (2022): 59-64.

Copyright

Copyright: © 2022 Katsuhisa Ikeda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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