Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Literature Review Volume 4 Issue 6

Smell and Taste Disorders in COVID-19: A Literature Review

Naif Yaseen Albar*

Department of Otorhinolaryngology, Head and Neck Surgery, King Abdulaziz University College of Medicine, Rabigh, Saudi Arabia

*Corresponding Author: Naif Yaseen Albar, Department of Otorhinolaryngology, Head and Neck Surgery, King Abdulaziz University College of Medicine, Rabigh, Saudi Arabia, ORCID: 0000-0001-7700-5852.

Received: May 25, 2022; Published: June 15, 2022

Abstract

Background: There is increasing evidence that the sudden olfactory dysfunctions (OD) and gustatory dysfunctions (GD) especially in the absence of nasal obstruction, rhinorrhea, or any upper respiratory symptoms, are common early symptoms of COVID-19. The objective of this review was to identify regional and worldwide prevalence of OD and GD in patients with COVID-19.

Methods: A search of the literature using keyword combinations was performed on the 1st of July 2020 among 4 major databases: PubMed, ScienceDirect, Web of Science, and Scopus. Preprints databases (Medrxiv, Biorxiv) were also searched for unpublished manuscripts. Only primary studies that reported on prevalence of OD/GD and written in English were selected. Data synthesis was narrative. Following the review, websites of relevant professional bodies were searched for guidelines and recommendations. Risk of bias was assessed with a 10-item tool.

Results: Twenty-nine articles reported OG or GD symptoms in 15830 patients. Studies have demonstrated great heterogeneity in the reported prevalence of anosmia as a COVID-19 symptom, from 5.1% to 98%. Caucasians have a higher prevalence than East Asians.

Discussion: Preliminary evidence suggests that differences in host or virus genotypes dominating different geographical regions may explain such heterogeneity in the reported prevalence of OD/GD among COVID-19 patients. However, there was no standardized method of detecting anosmia, limiting any strong conclusions. In regions with higher prevalence, OD/GD can be useful as a sensitive biomarker of COVID-19 that may help prioritization of COVID-19 testing and promote self-isolation which would reduce exposure to contagious but otherwise asymptomatic individuals who are much more difficult to identify.

Keywords: COVID-19; Taste Disorders; Olfaction Disorders; Prevalence; Anosmia

References

  1. Tranel D and Welsh-Bohmer KA. “Pervasive olfactory impairment after bilateral limbic system destruction”. Journal of Clinical and Experimental Neuropsychology 34 (2012): 117-125.
  2. Auffarth B. “Understanding smell—The olfactory stimulus problem”. Neuroscience and Biobehavioral Reviews 37 (2013): 1667-1679.
  3. Risso D., et al. “Alteration, Reduction and Taste Loss: Main Causes and Potential Implications on Dietary Habits”. Nutrients 12 (2020): 3284.
  4. Allis TJ and Leopold DA. “Smell and Taste Disorders”. Facial Plastic Surgery Clinics 20 (2012): 93-111.
  5. Suzuki M., et al. “Identification of Viruses in Patients With Post viral Olfactory Dysfunction”. The Laryngoscope 117 (2007): 272-277.
  6. Guan WJ., et al. “Clinical Characteristics of Coronavirus Disease 2019 in China”. The New England Journal of Medicine 382 (2020): 1708-1720.
  7. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  8. Kowalski LP., et al. “COVID‐19 pandemic: effects and evidence‐based recommendations for otolaryngology and head and neck surgery practice”. Head and Neck 42 (2020): 1259-1267.
  9. Singhal T. “A Review of Coronavirus Disease-2019 (COVID-19)”. Indian Journal of Pediatrics 87 (2020): 281-286.
  10. World Health Organization (WHO). WHO Coronavirus Disease (COVID-19) Dashboard (2020).
  11. Lovato A., et al. “Upper airway symptoms in coronavirus disease 2019 (COVID-19)”. American Journal of Otolaryngology 41 (2020):
  12. Lechien JR., et al. “Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study”. European Archives of Otorhinolaryngology 277 (2020): 2251-2261.
  13. Giacomelli A., et al. “Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study”. Clinical Infectious Diseases 71 (2020): 889-890.
  14. Rabin RC. “Lost sense of smell may be peculiar clue to coronavirus infection”. The New York Times (2020).
  15. Moher D., et al. “Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement”. PLoS Medicine7 (2009): e1000097.
  16. Schmithausen RM., et al. “Characteristic Temporary Loss of Taste and Olfactory Senses in SARS-CoV-2-positive-Individuals with Mild Symptoms”. Pathogens and Immunity 5 (2020): 117-120.
  17. Haehner A., et al. “Predictive Value of Sudden Olfactory Loss in the Diagnosis of COVID-19”. Journal for Oto-rhino-laryngology and its Related Specialties 82 (2020): 1-6.
  18. Hornuss D., et al. “Anosmia in COVID-19 patients”. Clinical Microbiology and Infection 26 (2020): 1426-1427.
  19. Luers JC., et al. “Olfactory and Gustatory Dysfunction in Coronavirus Disease 19 (COVID-19)”. Clinical Infectious Disease (2020): ciaa525.
  20. Carignan A., et al. “Anosmia and dysgeusia associated with SARS-CoV-2 infection: an age-matched case-control study”. CMAJ 192 (2020): E702-707.
  21. Mao L., et al. “Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study”. JAMA Neurology 77 (2020): 683-690.
  22. Bénézit F., et al. “Utility of hyposmia and hypogeusia for the diagnosis of COVID-19”. Lancet Infectious Disease 20 (2020): 1014-1015.
  23. Klopfenstein T., et al. “Features of anosmia in COVID-19”. Médecine et Maladies Infectieuses 50 (2020): 436-439.
  24. Zayet S., et al. “Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients”. Infection (2020): 1-5.
  25. Tsivgoulis G., et al. “Quantitative evaluation of olfactory dysfunction in hospitalized patients with Coronavirus (2) (COVID-19)”. Journal of Neurology 267 (2020): 2193-2195.
  26. Gudbjartsson DF., et al. “Spread of SARS-CoV-2 in the Icelandic Population”. The New England Journal of Medicine 382 (2020): 2302-2315.
  27. Moein ST., et al. “Smell dysfunction: a biomarker for COVID-19”. International Forum of Allergy and Rhinology 10 (2020): 944-950.
  28. Levinson R., et al. “Anosmia and dysgeusia in patients with mild SARS-CoV-2 infection”. MedRxiv (2020): 04.11.20055483.
  29. Vaira LA., et al. “Objective evaluation of anosmia and ageusia in COVID‐19 patients: Single‐center experience on 72 cases”. Head and Neck 42 (2020): 1252-1258.
  30. Spinato G., et al. “Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection”. JAMA 323 (2020): 2089-2090.
  31. Wee L., et al. “The role of self-reported olfactory and gustatory dysfunction as a screening criterion for suspected COVID-19”. European Archives of Otorhinolaryngology 277 (2020): 2389-2390.
  32. Chua AJ., et al. “Acute Olfactory Loss Is Specific for COVID-19 at the Emergency Department”. Annals of Emergency Medicine 76 (2020): 550-551.
  33. Lee Y., et al. “Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients”. Journal of Korean Medical Science 35 (2020): e174-e174.
  34. Beltrán‐Corbellini Á., et al. “Acute‐onset smell and taste disorders in the context of COVID‐19: a pilot multicentre polymerase chain reaction based case-control study”. European Journal of Neurology (2020): 27.
  35. Abalo-Lojo JM., et al. “Taste and Smell Dysfunction in COVID-19 Patients”. Annals of Otology, Rhinology and Laryngology: SAGE 129 (2020): 1041-1042.
  36. Sakalli E., et al. “Ear nose throat-related symptoms with a focus on loss of smell and/or taste in COVID-19 patients”. American Journal of Otolaryngology 41 (2020): 102622.
  37. Menni C., et al. “Real-time tracking of self-reported symptoms to predict potential COVID-19”. Nature Medicine 26 (2020): 1037-1040.
  38. Kaye R., et al. “COVID-19 Anosmia Reporting Tool: Initial Findings”. Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery 163 (2020): 132-134.
  39. Yan CH., et al. “Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms”. International Forum of Allergy and Rhinology 10 (2020): 806-813.
  40. Yan CH., et al. “Self-reported olfactory loss associates with outpatient clinical course in COVID-19”. International Forum of Allergy and Rhinology 10 (2020): 821-831.
  41. Wagner T., et al. “Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis”. ELife 9 (2020): e58227.
  42. Qiu C., et al. “Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study”. Otolaryngology–Head and Neck Surgery 163 (2020): 714-721.
  43. Hoy D., et al. “Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement”. Journal of Clinical Epidemiology9 (2012): 934-939.
  44. American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS). COVID-19 Anosmia Reporting Tool. American Academy of Otolaryngology - Head and Neck Surgery (2020).
  45. Bagheri SH., et al. “Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran”. Medical Journal of The Islamic Republic of Iran (MJIRI) 34 (2020): 62.
  46. von Bartheld CS., et al. “Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences”. MedRxiv (2020): 2020.06.15.20132134.
  47. Yao H., et al. “Patient-derived mutations impact pathogenicity of SARS-CoV-2”. MedRxiv (2020): 2020.04.14.20060160.
  48. Forster P., et al. “Phylogenetic network analysis of SARS-CoV-2 genomes”. Proceedings of the National Academy of Sciences 117 (2020): 9241-9243.
  49. Passali GC and Bentivoglio AR. “Comment to the article “Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study”. European Archives of Otorhinolaryngology 277 (2020): 2391-2392.
  50. American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS). AAO-HNS COVID-19 resources: Anosmia, Hyposmia, and Dysgeusia Symptoms of Coronavirus Disease (2020).
  51. Vaira LA., et al. “Anosmia and Ageusia: Common Findings in COVID‐19 Patients”. Laryngoscope (2020).
  52. Russell B., et al. “Anosmia and ageusia are emerging as symptoms in patients with COVID-19: What does the current evidence say?” Ecancermedicalscience (2020): 14.
  53. Hopkins C and Kumar N. “Loss of sense of smell as marker of COVID-19 infection” (2020).
  54. French Association of Rhinology (AFR), French Society of Otorhinolaryngology (SFORL). Consultations and Medical Treatments in Rhinology in the Context of the Covid-19 Epidemic: Guideline of Clinical Practice of the French Association of Rhinology (AFR) and of the French Society of Otorhinolaryngology (SFORL). Yo-Ifos (2020).
  55. UK Chief Medical Officers. Statement from the UK Chief Medical Officers on an update to coronavirus symptoms: 18 May 2020. GOVUK 2020 (2020).
  56. Centers for Disease Control and Prevention. Symptoms of Coronavirus. CDC - Centers for Disease Control and Prevention (2020).
  57. World Health Organization (WHO). Coronavirus. WHO (2020).

Citation

Citation: Naif Yaseen Albar. “Smell and Taste Disorders in COVID-19: A Literature Review".Acta Scientific Otolaryngology 4.7 (2022): 39-48.

Copyright

Copyright: © 2022 Naif Yaseen Albar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate34%
Acceptance to publication20-30 days
Impact Factor0.871

Indexed In







News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US