Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 4 Issue 5

Evaluation of Olfactory Dysfunction in Patients with COVID-19

Mylene Lopes Frota*, Dayane Resende da Mata, Mateus Pinto Ribeiro, Stanley Bras Sperandio and Mirian Cabral Moreira de Castro

Otolaryngology Department, Santa Casa de Belo Horizonte, Brazil

*Corresponding Author: Milene Lopes Frota, Otolaryngology Department, Santa Casa de Belo Horizonte, Brazil.

Received: April 05, 2022; Published: April 29, 2022

Abstract

In the present context of the COVID-19 pandemic, the olfactory dysfunctions (OD) in patients that are positive for SARS-CoV-2 have been more intense and of early emergence, which is the reason why it is important to study the olfactory function in these patients.

The purpose of this study was the evaluation of the olfactory dysfunction measured through threshold and olfactory discrimination tests (Connecticut). The research was carried out at the Respiratory Hospital of the Santa Casa de Belo Horizonte and included 99 patients infected with SARS-CoV-2, who were evaluated from July 2020 to February 2021. The olfactory test showed that 66% of the patients had some degree of hyposmia in the right nasal cavity and 69,1% in the left nasal cavity. The ages ranged from 19 to 86 years old and the average age was 58.7 years old (+-14.5). When comparing gender and age (< = 60 years old and > 60 years old) in relation to the highest degree of hyposmia, it was possible to verify that the gender variable (male VS. female) did not show a significative difference in hyposmia, p = 0.845. In relation to age, it was possible to see a statistically significant difference, p = 0.003. Patients under the age of 60 showed a higher proportion of normality, followed by mild and moderate hyposmia when compared to those aged 61 and over. The proportion of severe hyposmia/anosmia was higher in those aged 61 and over.

Keywords: Smell; Anosmia; Olfactory Dysfunction; COVID-19; Connecticut

References

  1. Mutiawati Endang., et al. "Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms-a systematic review and meta-analysis”. F1000Research10 (2021).
  2. Meng Xiangming., et al. "COVID-19 and anosmia: A review based on up-to-date knowledge”. American Journal of Otolaryngology5 (2020): 102581.
  3. Mastrangelo Andrea., et al. "Smell and taste disorders in COVID-19: from pathogenesis to clinical features and outcomes”. Neuroscience Letters748 (2021): 135694.
  4. Rocke John., et al. "Is loss of sense of smell a diagnostic marker in COVID‐19: a systematic review and meta‐analysis”. Clinical Otolaryngology6 (2020): 914-922.
  5. Borsetto Daniele., et al. "Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients”. Rhinology5 (2020): 430-436.
  6. Aziz Muhammad., et al. "The association of “loss of smell” to COVID-19: a systematic review and meta-analysis”. The American Journal of the Medical Sciences2 (2021): 216-225.
  7. Glezer Isaias., et al. "Viral infection and smell loss: The case of COVID‐19”. Journal of Neurochemistry4 (2021): 930-943.
  8. Saussez Sven., et al. "Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered”. European Archives of Oto-rhino-laryngology7 (2021): 2187-2191.
  9. de Souza Ellen Lelis., et al. "A importância do plasma convalescente e/ou globulina hiperimune em pacientes com doença coronavírus 2019 (Covid-19)/The importance of convalescent plasma and/or hyperimmune globulin in patients with coronavirus disease 2019 (Covid-19)”. Brazilian Journal of Health Review5 (2021): 22506-22514.
  10. Kosugi Eduardo Macoto., et al. "Recuperação incompleta e tardia da perda súbita do olfato na COVID-19”. Brazilian Journal of Otorhinolaryngology86 (2020): 490-496.
  11. Romano Fabrizio Ricci., et al. "Olfato e Paladar: Da Anatomofisiologia ao Diagnóstico e Tratamento”. Thieme Revinter, (2021).
  12. Brandão Neto Deusdedit., et al. "Chemosensory dysfunction in COVID-19: prevalences, recovery rates, and clinical associations on a large Brazilian sample”. Otolaryngology–Head and Neck Surgery3 (2021): 512-518.
  13. Yan CH., et al. "Self-reported olfactory loss associates with outpatient clinical course in COVID-19”. International Forum of Allergy and Rhinology 7 (2020): 821-831.
  14. Moein Shima T., et al. "Smell dysfunction: a biomarker for COVID‐19”. International forum of allergy and Rhinology8 (2020).
  15. Hopkins Claire., et al. "Self‐reported olfactory loss in COVID‐19: is it really a favorable prognostic factor?”. International Forum of Allergy and Rhinology. Wiley-Blackwell, (2020).
  16. Vaira Luigi Angelo., et al. "Objective evaluation of anosmia and ageusia in COVID‐19 patients: single‐center experience on 72 cases”. Head and Neck6 (2020): 1252-1258.
  17. Brandão Neto Deusdedit., et al. "Chemosensory dysfunction in COVID-19: prevalences, recovery rates, and clinical associations on a large Brazilian sample”. Otolaryngology–Head and Neck Surgery3 (2021): 512-518.
  18. Henkin Robert I., et al. "Interleukin 6 in hyposmia”. JAMA Otolaryngology–Head and Neck Surgery7 (2013): 728-734.

Citation

Citation: Mylene Lopes Frota., et al. “Evaluation of Olfactory Dysfunction in Patients with COVID-19". Acta Scientific Otolaryngology 4.5 (2022): 71-76.

Copyright

Copyright: © 2022 Mylene Lopes Frota., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate34%
Acceptance to publication20-30 days
Impact Factor0.871

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