Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Case Report Volume 4 Issue 4

Endoscopic Endonasal Excision of Solitary Neurofibroma Arising from Anterior Nasal Septum: A Case Report and Clinical Review

Sourabh Shankar Chakraborty1, Anil Kumar Monga2, Neha Shakrawal3* and Sudeshna Acharya4

1Department of Burns and Plastic Surgery, South Eastern Railway Central Hospital, Kolkata, India
2Department of Otorhinolaryngology, Sir Ganga Ram Hospital, Delhi, India
3Department of Otorhinolaryngology, All India Institute of Medical Sciences, Delhi, India
4Emergency Department, Goodwill Nursing Home, Kolkata, India

*Corresponding Author: Neha Shakrawal, Assistant Professor, Department of Otorhinolaryngology, All India Institute of Medical Sciences, Delhi, India.

Received: February 18, 2022; Published: March 24, 2022


class="BodyA" style="text-align: justify; line-height: 150%;">Background: Neurogenic tumors are rare neoplastic lesions of head and neck region. Benign peripheral nerve sheath tumors arising from nose have been rarely documented in the literature. Only six reports of solitary nasal septal neurofibroma in English literature existed. We present a case of solitary neurofibroma originating from left side of anterior nasal septum in a 40 years old female. Endoscopic endonasal excision was done. At six years follow-up, there was no evidence of recurrence. However rare, solitary neurofibroma must be contemplated in the differentials of unilateral benign tumor involving nasal and paranasal sinuses.

 Keywords: Solitary Neurofibroma; Peripheral Nerve Sheath Tumors; Nasal Septum; Endoscopic Excision


  1. Batsakis J. “Tumors of the head and neck. Clinical and pathological consideration (2nd ed)”. Baltimore: Williams and Wilkins (1979): 313-333.
  2. Annino DJ., et al. “A rare cause of nasal obstruction: A solitary neurofibroma”. Otolaryngology–Head and Neck Surgery 104 (1991): 484-488.
  3. Hillstrom RP., et al. “Nerve sheath tumors of the paranasal sinuses: Electron microscopy and histopathologic diagnosis”. Otolaryngology–Head and Neck Surgery 102 (1990): 257-263.
  4. Souza L., et al. “Neurofibroma paciniano: Relato de um caso raro de localizacao itraoral”. Brazilian Journal of Otorhinolaryngology 69 (2003): 851-854.
  5. Kim YD., et al. “Transnasal endoscopic excision of an isolated neurofibroma of the nasal septum”. Rhinology 35 (1997): 89-91.
  6. Fraczek M., et al. “Two cases of nasal neurofibroma”. Journal of Otorhinolaryngology 5 (2006): 1-9.
  7. Kohli PS and Goel K. “Endoscopic Excision of Solitary Neurofibroma Arising from Posterior nasal septum”. Clinical Rhinology Journal 4 (2011): 43-46.
  8. Kim KS. “Solitary Neurofibroma Originating From the Nasal Septum”. Journal of Craniofacial Surgery 26 (2015): 2235-2236.
  9. Tall A., et al. “Solitary neurofibroma originating from the posterior nasal seprum: Transnasal endoscopic resection”. European Annals of Otorhinolaryngology, Head and Neck Diseases 132 (2015): 223-225.
  10. Katre MI., et al. “Neurofibroma of Nasal Cavity and Nasopharynx”. Advertising Case Studies 1 (2017): AICS.000503.
  11. Morris JH. “The nervous system”. In: Cotran RS, Kumar V, et al. ed. Robbin's Pathologic Basis of Disease. Philadelphia, W.B. Saunders (1989): 1445-1446.
  12. Hellquist HB. “Pathology of the Nose and Paranasal Sinuses”. London, Butterworths (1990): 104-105.
  13. Perzin K., et al. “Nonepithelial tumour of the nasal cavity, paranasal sinuses and nasopharynx- A Clinicopathological study, XII: Schwann cell tumors (Neurilemoma, Neurofibroma, Malignant Schwannoma)”. Cancer 50 (1982): 2193-2202.
  14. Hirao M., et al. “Solitary neurofibroma of nasal cavity: Resection with endoscopic surgery”. Journal of Laryngology and Otology 115 (2001): 1012-1014.
  15. Moreno PM and Meseguer DH. “Solitary neurofibroma of the inferior nasal turbinate”. Auris Nasus Larynx 25 (1998): 329-31.
  16. Chakravarti A., et al. “Solitary neurofibroma causing nasal obstruction”. Journal of Indian Medical Association 97 (1999): 526.
  17. Chua CN., et al. “Solitary nasal neurofibroma presenting as compressive optic neuropathy”. Eye (Lond) 20 (2006): 1406-1408.
  18. Manganaris A., et al. “A peripheral nerve sheath tumour as a cause of nasal obstruction”. Journal of Laryngology and Otology 120 (2006): e44.
  19. Shah S., et al. “Neurofibroma of middle meatus: A case report and review of literature”. Napalese Journal of ENT Head and Neck Surgery 2 (2010): 19-20.
  20. Azani AB., et al. “Sinonasal tract neurofibroma: A clfinicopathologic series of 12 cases with review of literature”. Head and Neck Pathology 9 (2015): 323-333.


Citation: Neha Shakrawal., et al. “Endoscopic Endonasal Excision of Solitary Neurofibroma Arising from Anterior Nasal Septum: A Case Report and Clinical Review".Acta Scientific Otolaryngology 4.4 (2022): 58-62.


Copyright: © 2022 Neha Shakrawal., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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