Case-control Study to Evaluate the Association Between Reinke’s Edema and Central Hypothyroidism
Lucas Daykson David Macedo de Oliveira1*, Geraldo Druck Sant'anna2, Davi Sandes Sobral3, Paulo Sergio Lins Perazzo3, Helissandro Andrade Coelho1, Laise Araujo Aires dos Santos4, Maria Luiza Coelho de Sousa5 and Adrielle Almeida de Jesus5
1Otorrinolaryngoloy, Santo Antonio Hospital, Brazil
2Otorrinolaryngoloy, Santa Casa de Porto Alegre, Brazil
3Otorrinolaryngoloy, Otorrinos, Feira de Santana, Brazil
4Otorrinolaryngoloy, Inooa - Salvador, Brazil
5Otorrinolaryngoloy, Universidade Tiredentes, Aracaju, Brazil
*Corresponding Author: Lucas Daykson David Macedo de Oliveira, Otorrinolaryngoloy, Santo Antonio Hospital, Brazil.
October 04, 2021; Published: December 31, 2021
Objective: To evaluate the association between Reinke’s Edema and central hypothyroidism in the population from the state of Bahia.
Methods: It was held a longitudinal observational study of the type of case control study. The case group was formed by patients with Reinke’s Edema, aged 40 years or more. Control group was made by female patients aged 40 years or more with other benign pathologies of the larynx. The diagnosis of central hypothyroidism is based on the biochemical analysis: the patients show low circulating concentrations of free T4, associated to normal to low serum levels of TSH.
Results: The study had 26 patients in the case group and 26 in the control group. Central hypothyroidism was found in 17,6% of the case group; as it had not been found in the control group, it was not possible to calculate the OR; however, data showed statistical significance (p 0,034).
Conclusion: When compared to the primary one, and, usually, it does not show goiter, and the TSH values, in most the cases, are not high; these characteristics seem to make it difficult the clinical suspicion, and it can cause controversies regarding the association between hypothyroidism and Reinke’s edema.
Keywords: Reinke’s Edema; Hypothyroidism; Central Hypothyroidism
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