Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 4 Issue 1

Case-control Study to Evaluate the Association Between Reinke’s Edema and Central Hypothyroidism

Lucas Daykson David Macedo de Oliveira1*, Geraldo Druck Sant'anna2, Davi Sandes Sobral3, Paulo Sergio Lins Perazzo3, Helissandro Andrade Coelho1, Laise Araujo Aires dos Santos4, Maria Luiza Coelho de Sousa5 and Adrielle Almeida de Jesus5

1Otorrinolaryngoloy, Santo Antonio Hospital, Brazil
2Otorrinolaryngoloy, Santa Casa de Porto Alegre, Brazil
3Otorrinolaryngoloy, Otorrinos, Feira de Santana, Brazil
4Otorrinolaryngoloy, Inooa - Salvador, Brazil
5Otorrinolaryngoloy, Universidade Tiredentes, Aracaju, Brazil

*Corresponding Author: Lucas Daykson David Macedo de Oliveira, Otorrinolaryngoloy, Santo Antonio Hospital, Brazil.

Received: October 04, 2021; Published: December 31, 2021

Abstract

Objective: To evaluate the association between Reinke’s Edema and central hypothyroidism in the population from the state of Bahia.

Methods: It was held a longitudinal observational study of the type of case control study. The case group was formed by patients with Reinke’s Edema, aged 40 years or more. Control group was made by female patients aged 40 years or more with other benign pathologies of the larynx. The diagnosis of central hypothyroidism is based on the biochemical analysis: the patients show low circulating concentrations of free T4, associated to normal to low serum levels of TSH.

Results: The study had 26 patients in the case group and 26 in the control group. Central hypothyroidism was found in 17,6% of the case group; as it had not been found in the control group, it was not possible to calculate the OR; however, data showed statistical significance (p 0,034).

Conclusion: When compared to the primary one, and, usually, it does not show goiter, and the TSH values, in most the cases, are not high; these characteristics seem to make it difficult the clinical suspicion, and it can cause controversies regarding the association between hypothyroidism and Reinke’s edema.

Keywords: Reinke’s Edema; Hypothyroidism; Central Hypothyroidism

References

  1. Hirano Minoru. "Morphological structure of the vocal cord as a vibrator and its variations”. Folia Phoniatrica et Logopaedica2 (1974): 89-94.
  2. Altman Kenneth W., et al. "Identification of thyroid hormone receptors in the human larynx”. The Laryngoscope11 (2003): 1931-1934.
  3. White A., et al. "Reinke's oedema and thyroid function”. The Journal of Laryngology and Otology4 (1991): 291-292.
  4. Brodnitz Friedrich S. "Goals, results and limitations of vocal rehabilitation”. Archives of Otolaryngology2 (1963): 44-52.
  5. Lindeberg H E N N I N G., et al. "Reinke's oedema and thyroid function: a prospective study in 43 patients”. Clinical otolaryngology and allied sciences6 (1987): 417-420.
  6. Benfari, G. et al. “[Thyroid gland stimulation test in Reinke's edema. A study of 28 patients]”. Anales Otorrinolaringologicos Ibero-Americanos195 (1992): 485-491 .
  7. Daykson david macedo de oliveira, lucas. "Avaliação do perfil metabólico dos pacientes do sexo feminino com edema de reinke". Anais do 49º Congresso da ABORL-CCF (2019): 35.
  8. Eggertsen R K P E G., et al. "Screening for thyroid disease in a primary care unit with a thyroid stimulating hormone assay with a low detection limit”. British Medical Journal6663 (1988): 1586-1592.
  9. Yamada Masanobu and Masatomo Mori. "Mechanisms related to the pathophysiology and management of central hypothyroidism”. Nature Clinical Practice Endocrinology and Metabolism12 (2008): 683-694.
  10. Lania Andrea., et al. "Central hypothyroidism”. Pituitary2 (2008): 181-186.
  11. Alafif M M., et al. "Case Report: Central Diabetes Insipidus, Central Hypothyroidism, Renal Tubular Acidosis and Dandy‑Walker Syndrome: New Associations”. Annals of Medical and Health Sciences Research2 (2015): 145-147.
  12. Zwaveling-Soonawala., et al. "The severity of congenital hypothyroidism of central origin should not be underestimated”. The Journal of Clinical Endocrinology and Metabolism2 (2015): E297-E300.
  13. Grunenwald S and Caron P. “Central hypothyroidism in adults: better understanding for better care”. Pituitary 1 (2015): 169-175.
  14. García Marta., et al. "Central hypothyroidism in children”. Paediatric Thyroidology26 (2014): 79-107.
  15. Price Alun and A P Weetman. "Screening for central hypothyroidism is unjustified”. Bmj7289 (2001): 798.
  16. Horimoto M A S A T E R U., et al. "Bioactivity of thyrotropin (TSH) in patients with central hypothyroidism: comparison between in vivo 3, 5, 3'-triiodothyronine response to TSH and in vitro bioactivity of TSH”. The Journal of Clinical Endocrinology and Metabolism4 (1995): 1124-1128.
  17. Beck-Peccoz Paolo and Luca Persani. "Variable biological activity of thyroid-stimulating hormone”. European Journal of Endocrinology4 (1994): 331-340.
  18. Persani Luca., et al. "Circulating thyrotropin bioactivity in sporadic central hypothyroidism”. The Journal of Clinical Endocrinology and Metabolism10 (2000): 3631-3635.
  19. Beck-Peccoz Paolo., et al. "Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism: effect of treatment with thyrotropin-releasing hormone”. New England Journal of Medicine17 (1985): 1085-1090.
  20. Persani Luca. "Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity”. Thyroid10 (1998): 941-946.
  21. Faglia Giovanni., et al. "Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin”. The Journal of Clinical Endocrinology and Metabolism6 (1979): 989-998.
  22. Lee KO., et al. "Thyrotropin with decreased biological activity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma”. Journal Of Endocrinological Investigation10 (1995): 800-805.
  23. Oliveira Juliana HA., et al. "Investigating the paradox of hypothyroidism and increased serum thyrotropin (TSH) levels in Sheehan’s syndrome: characterization of TSH carbohydrate content and bioactivity”. The Journal of Clinical Endocrinology and Metabolism4 (2001): 1694-1699.
  24. Papandreou Marie Jeanne., et al. "Variable carbohydrate structures of circulating thyrotropin as studied by lectin affinity chromatography in different clinical conditions”. The Journal of Clinical Endocrinology and Metabolism2 (1993): 393-398.
  25. Persani Luca., et al. "Changes in the degree of sialylation of carbohydrate chains modify the biological properties of circulating thyrotropin isoforms in various physiological and pathological states”. The Journal of Clinical Endocrinology and Metabolism7 (1998): 2486-2492.
  26. Szkudlinski Mariusz W., et al. "Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships”. Physiological Reviews2 (2002): 473-502.
  27. Gurnell Mark., et al. "What should be done when thyroid function tests do not make sense?”. Clinical endocrinology6 (2011): 673-678.
  28. Kratz Alexander., et al. "Laboratory reference values”. New England Journal of Medicine351 (2004): 1548-1564.
  29. Pfäffle R and J Klammt. "Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency”. Best Practice and Research Clinical Endocrinology and Metabolism1 (2011): 43-60.
  30. Castinetti Frederic., et al. "Mechanisms in endocrinology: an update in the genetic aetiologies of combined pituitary hormone deficiency”. European Journal of Endocrinology6 (2016): R239-R247.
  31. Doin Fabio Casanova., et al. "Diagnosis of subclinical central hypothyroidism in patients with hypothalamic-pituitary disease by Doppler echocardiography”. European Journal of Endocrinology4 (2012): 631.
  32. Koulouri, Olympia, et al. "Pitfalls in the measurement and interpretation of thyroid function tests”. Best Practice and Research Clinical Endocrinology and Metabolism6 (2013): 745-762.
  33. Beck-Peccoz Paolo., et al. "Central hypothyroidism—a neglected thyroid disorder”. Nature Reviews Endocrinology10 (2017): 588-598.
  34. Beck‐Peccoz Paolo. "Treatment of central hypothyroidism”. Clinical Endocrinology6 (2011): 671-672.
  35. Iverson Jennifer F and Cary N Mariash. "Optimal free thyroxine levels for thyroid hormone replacement in hypothyroidism”. Endocrine Practice5 (2008): 550-555.

Citation

Citation: Lucas Daykson David Macedo de Oliveira., et al. “Case-control Study to Evaluate the Association Between Reinke’s Edema and Central Hypothyroidism".Acta Scientific Otolaryngology 4.1 (2022): 71-76.

Copyright

Copyright: © 2022 Lucas Daykson David Macedo de Oliveira., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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