Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 4 Issue 1

The Giant Size Parotid Lesions

Mario Mannino*, Giorgio Barbera, Davide Soverina, Gemma Mastrantoni, Gianmarco Saponaro, Giulio Gasparini, Sandro Pelo and Alessandro Moro

Department of Maxillofacial Surgery, Università Cattolica del Sacro Cuore (RM), Italy

*Corresponding Author: Mario Mannino, Department of Maxillofacial Surgery, Università Cattolica del Sacro Cuore (RM), Italy.

Received: December 13, 2021; Published: December 31, 2021


Introduction: Parotid tumors are usually slow growing, asymptomatic masses and the average size reported to be between 2 and 6 cm [9]. In the literature, some cases of ”giant tumors” of the parotid are mentioned, most of them benign, but there isn’t a clear definition of this term.

This article will examine all the lesions that include the term “giant”, trying to find a definition, a size cut-off, epidemiologic and clinical characteristics.

Materials and Methods: The search of the major databases (PubMed, Cochrane and Scopus) was performed until December 29, 2019.

Randomized controlled trials (RCTs), case series, case reports, reviews of the literature, interventional or observational studies were considered and the inclusion criteria were as follows:

  • Studies reporting malignant or benign parotid tumors with dimension;
  • Definition as “giant”, “huge” or other terms that emphasize the dimension of the tumor;
  • Primary parotid

Letters to editor were excluded and the following exclusion criteria were applied:

  • Studies without indications about tumor

Results: The studies included a total of 43 patients with giant parotid tumor. 37 out of 39 articles were case reports and 2 articles were case series.

The size of the lesion depends on the period of time from clinical onset to giant transformation reported (co-gtr).

In 2 cases of malignant tumor the growth was extremely fast.

The correlation between “size” and co-gtr is high and positive (equal to 0.69) and the ratio is statistically significant (P < 0.05), that means the larger the size the longer the time since clinical onset to giant transformation reported.

The average detected size was 14.2 cm and two peaks were found at 6cm and 20cm. (range 3-46cm).

The larger part of the tumours are benignant (75%), of which pleomorphic adenoma is the most represented (47%). In the malignant group, half of them are carcinoma ex pleomorphic adenoma.


  • The size of the tumors depends on neglection and this does not only apply to underdeveloped countries but also to the western world, being largely linked to the refusal of treatment and perhaps to medical/patient wrong communication.
  • Two dimensional peaks were find regarding the metrical size of the lesions. The first peak was the most numerous and equal to 6 cm and we suggest to take it as a cut-off to classify the lesion as GIANT. Lower values are therefore excluded and considered within the common size of parotid lesions.
  • The evolution in malignant tumor of giant pleomorphic adenoma in 20 years is 20%. The absence of surgery leads to an increase in the size of the neoformation, an increased risk of cancer evolution that confirms the need of surgery in such lesions.

Keywords: Parotid Gland; Salivary Gland; Giant


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Citation: Mario Mannino., et al. “The Giant Size Parotid Lesions".Acta Scientific Otolaryngology 4.1 (2022): 55-65.


Copyright: © 2022 Mario Mannino., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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