Himani-Tiwari Chaturvedi¹* and Vandana Shah²

¹Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Dharmsinh Desai University, Nadiad, India
²Department of Oral and Maxillofacial Pathology, K M Shah Dental College, SVU, Piparia, India

*Corresponding Author: Himani Tiwari Chaturvedi, A1/57, Darshanam Greens, BH Baroda Public School, Near Nathdwara Residency, Dabhoi Waghodia Ring Road, Vadodara 390 019, Gujarat, India. E-mail: himanicsc@gmail.com

Received: September 15, 2021; Published: September 27, 2021

Abstract

  Oral leukoplakia and oral squamous cell carcinoma (OSCC) are the commonly occurring oral diseases, with characteristic clinical and histological features. These diseases at some stages are associated with chronic inflammation in adjacent connective tissue. Mast cells are granule-containing secretory cells which are local residents of the connective, scattered along the capillaries of oral mucosa. They are proinflammatory and expressed the serine proteases, tryptase and chymase along with cytokines and may play a significant role in the pathogenesis of oral diseases. The aim of the study was to histologically evaluate and compare the presence of mast cells in Normal mucosa, Leukoplakia and Well differentiated oral squamous cell carcinoma. Thirty cases each of normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma (OSCC) were studied for mast cell number using 1% Toluidine blue. There was a linear increase in mast cell numbers were seen in leukoplakia and OSCC as compared to normal mucosa. Mast cell hyperplasia in oral leukoplakia and OSCC suggests their probable role in the pathogenesis of these diseases.

Keywords: Mast Cells; Oral Submucous Fibrosis; Oral Leukoplakia; Oral Squamous Cell Carcinoma

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Citation

Citation: Himani-Tiwari Chaturvedi and Vandana Shah. “Comparison of Distribution of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma - A Retrospective Study".Acta Scientific Otolaryngology 3.10 (2020): 75-79.

Copyright

Copyright: © 2020 Himani-Tiwari Chaturvedi and Vandana Shah. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.