Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 3 Issue 10

Results Frequency Analysis Distribution of Alleles and Genotypes of the Polymorphic Marker Rs1800471 of the Tgfb1 Gene in Patients with Ronchopathy

US Khasanov1* and SS Sharipov2

1Doctor of Medical Science, Professor, Head of the Department of Otolaryngology and Stomatology, Tashkent Medical Academy, Tashkent, Republic of Uzbekistan
2Doctor of Philosophy of Medical Science (PhD), Associate Professor of the Department of Otorhinolaryngology, Tashkent State Dental Institute, Tashkent, Republic of Uzbekistan

*Corresponding Author: US Khasanov, Doctor of Medical Science, Professor, Head of the Department of Otolaryngology and Stomatology, Tashkent Medical Academy, Tashkent, Republic of Uzbekistan.

Received: August 05, 2021; Published: September 25, 2021

Abstract

Introduction: Snoring is the most common type of sleep apnea. Ronchopathy is caused by obstruction of the upper airways. This condition is characterized by repeated pauses in breathing during sleep, despite the efforts of the respiratory muscles, and, as a rule, is associated with a decrease in blood oxygen saturation.

The Research Objective: To study the distribution of genotypic forms of the TGFb1 gene locus and evaluate their role in the development and clinical course of ronchopathy.

Materials and Methods: 208 patients with various diseases of the upper respiratory tract, with nasal breathing disorders, causing ronchopathy, who were hospitalized in the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy for 2015 to 2021, were examined. The control group consisted of 50 apparently healthy people who agreed to participate in the study (students, masters, clinical residents). Among the sick men there were 144 (73%), women - 64 (27%).

Results and Discussion: For an unambiguous assessment of the role of the rs1800471 polymorphism of the TGFb1 gene in the formation of impaired nasal breathing and the development of ronchopathy, we believe that additional and in-depth studies are necessary with an increase in the number of patients and control. It is interesting to note that the adverse effect of this genotype was observed exclusively in patients with ronchopathy, while in patients with ronchopathy, the frequency of this genotype did not differ in comparison with the control group, i.e. there is a significant tendency to an increase in the genotype with an increase in the severity of the pathology.

Conclusion: Since this work is one of the few works on the study of the relationship between rs1800471 of the TGFb1 gene and the risk of developing ronchopathy, our data may become the subject of further discussions.

Keywords: Ronchopathy; Gene; Allele; Genotype; Polymorphism; Sleep Apnea

References

  1. Braun N., et al. “Gene polymorphism at position-308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and it’s influence on the regulation of TNF-alpha production”. Neuroscience Letters2 (1996): 75-78.
  2. Rasche K. “Snoring and daytime sleepiness”. MMW - Fortschritte der Medizin3 (2018): 42-44.
  3. Ribeiro DK., et al. “Forestier syndrome and obstructive sleep apnea: Surgical treatment”. European Annals of Otorhinolaryngology, Head and Neck Diseases3 (2018): 209-211.
  4. Robbins R., et al. “National patterns of physician management of sleep apnea and treatment among patients with hypertension”. PLoS One5 (2018).
  5. Tamayo Martínez N and Rosselli Cock D. “Obstructive sleep apnea syndrome in patients attending a psychiatry outpatient service: a case series”. The Revista Colombiana de Psiquiatría4 (2017): 243-246.
  6. Tingting X., et al. “Non-surgical treatment of obstructive sleep apnea syndrome”. European Archives of Oto-Rhino-Laryngology2 (2018): 335-346.
  7. Álvarez ML., et al. “Treatment of Obstructive Sleep Apnea Syndrome in Children: More Options, More Confusion”. Archivos de Bronconeumología (2018): S0300-2896.
  8. Trzepizur W., et al. “Vascular dysfunction in obstructive sleep apnoea: Implication of microparticules”. Revue de Pneumologie Clinique6 (2017): 306-308.
  9. Vickers MA., et al. “Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein”. Cardiovascular Research4 (2002): 1029-1034.
  10. Vincenti V., et al. “Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3”. Circulation 93 (1996): 1493-1495.
  11. West SD and Turnbull C. “Corneal Biomechanical Properties in Obstructive Sleep Apnea Syndrome.Obstructive sleep apnoea”. Eye5 (2018): 889-903.
  12. Willen SM., et al. “Sleep disordered breathing does not predict acute severe pain episodes in children with sickle cell anemia”. American Journal of Hematology4 (2018): 478-485.
  13. Wolf J and Narkiewicz K. “Managing comorbid cardiovascular disease and sleep apnea with pharmacotherapy”. Expert Opinion on Pharmacotherapy 24 (2018): 1-9.
  14. Woodson BT., et al. “Radiofrequency ablation of the lateral palatal space for snoring”. The World Journal of Otorhinolaryngology – Head and Neck Surgery2 (2017): 106-109.
  15. Wu J., et al. “Evaluation of the subjective efficacy of nasal surgery”. The Journal of Laryngology and Otology1 (2017): 37-43.
  16. Zakhama L., et al. “Impact of obstructive sleep apnea on the right ventricle”. La Tunisie Medical10 (2016): 612-615.
  17. Zalzal HG., et al. “Drug Induced Sleep Endoscopy Identification of Adenoid Regrowth in Pediatric Obstructive Sleep Apnea”. International Journal of Otolaryngology (2018).
  18. Zhang S., et al. “Advances in preoperative screening of obstructive sleep apnea hypopnea syndrome 41.1 (2018): 57-59.
  19. Zhang ZY., et al. “Obstructive sleep apnea-hypopnea syndrome complicated with obesity hypoventilation syndrome: a case report 52.11 (2017): 859-861.
  20. Zhao G., et al. “The predictive value of polysomnography combined with quality of life for treatment decision of children with habitual snoring related to adenotonsillar hypertrophy”. European Archives of Oto-Rhino-Laryngology6 (2018): 1579-1586.

Citation

Citation: US Khasanov and SS Sharipov. “Results Frequency Analysis Distribution of Alleles and Genotypes of the Polymorphic Marker Rs1800471 of the Tgfb1 Gene in Patients with Ronchopathy". Acta Scientific Otolaryngology 3.10 (2021): 62-69.

Copyright

Copyright: © 2021 US Khasanov and SS Sharipov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate34%
Acceptance to publication20-30 days
Impact Factor0.871

Indexed In








News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 30, 2022.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US