US Khasanov1* and SS Sharipov2
1Doctor of Medical Science, Professor, Head of the Department of Otolaryngology and Stomatology, Tashkent Medical Academy, Tashkent, Republic of Uzbekistan
2Doctor of Philosophy of Medical Science (PhD), Associate Professor of the Department of Otorhinolaryngology, Tashkent State Dental Institute, Tashkent, Republic of Uzbekistan
*Corresponding Author: US Khasanov, Doctor of Medical Science, Professor, Head of the Department of Otolaryngology and Stomatology, Tashkent Medical Academy, Tashkent, Republic of Uzbekistan.
Received: August 05, 2021; Published: September 25, 2021
Introduction: Snoring is the most common type of sleep apnea. Ronchopathy is caused by obstruction of the upper airways. This condition is characterized by repeated pauses in breathing during sleep, despite the efforts of the respiratory muscles, and, as a rule, is associated with a decrease in blood oxygen saturation.
The Research Objective: To study the distribution of genotypic forms of the TGFb1 gene locus and evaluate their role in the development and clinical course of ronchopathy.
Materials and Methods: 208 patients with various diseases of the upper respiratory tract, with nasal breathing disorders, causing ronchopathy, who were hospitalized in the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy for 2015 to 2021, were examined. The control group consisted of 50 apparently healthy people who agreed to participate in the study (students, masters, clinical residents). Among the sick men there were 144 (73%), women - 64 (27%).
Results and Discussion: For an unambiguous assessment of the role of the rs1800471 polymorphism of the TGFb1 gene in the formation of impaired nasal breathing and the development of ronchopathy, we believe that additional and in-depth studies are necessary with an increase in the number of patients and control. It is interesting to note that the adverse effect of this genotype was observed exclusively in patients with ronchopathy, while in patients with ronchopathy, the frequency of this genotype did not differ in comparison with the control group, i.e. there is a significant tendency to an increase in the genotype with an increase in the severity of the pathology.
Conclusion: Since this work is one of the few works on the study of the relationship between rs1800471 of the TGFb1 gene and the risk of developing ronchopathy, our data may become the subject of further discussions.
Keywords: Ronchopathy; Gene; Allele; Genotype; Polymorphism; Sleep Apnea
Citation: US Khasanov and SS Sharipov. “Results Frequency Analysis Distribution of Alleles and Genotypes of the Polymorphic Marker Rs1800471 of the Tgfb1 Gene in Patients with Ronchopathy". Acta Scientific Otolaryngology 3.10 (2021): 62-69.
Copyright: © 2021 US Khasanov and SS Sharipov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.