Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Review Article Volume 3 Issue 9

Etiopathogenesis and Prognosis of Altered Taste and Smell Sensation in Covid 19 Patients

Rashmi Nambiar1*, Sumit Sharma2 and Suvarna Sharma3

1Postgraduate Junior Resident-First Year, Department of ENT, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India
2Associate Professor, Department of ENT, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India
3MBBS 5th year Students, KMC Manipal, Manipal, Karnataka, India

*Corresponding Author: Rashmi Nambiar, Postgraduate Junior Resident-First Year, Department of ENT, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India.

Received: July 19, 2021; Published: August 09, 2021

Abstract

Altered taste and smell sensation is being reported commonly in Covid patients. Human strains of corona virus have been demonstrated to invade the central nervous system through the olfactory neuroepithelium and propagate from within the olfactory bulb. Nasal epithelial cells display the highest expression of the SARS-CoV-2 receptor, angiotensin converting enzyme 2, in the respiratory tree. The condition is more commonly associated in patients with mild disease. Initially there were concerns that the virus can reach the brain through olfactory bulb but post-mortem studies of people who had had COVID-19 have shown that the virus rarely reaches the brain. According to the OLFACAT survey, loss of smell, either hyposmia or anosmia was seen in virtually 2 hundredth of the European general population. Loss of smell is taken into account to possess a major impact on quality of life. The article is aimed to summaries the Incidence; causes and recovery pattern of the Covid associated altered taste and smell sensation.

WE concluded that Anosmia may be thought to be an unknown neurologic symptom in COVID-19. Within the early stage of the disease anosmia and ageusia appear to be a part of vital symptoms and clues for diagnosing COVID-19. The acute onset of loss smell and loss of taste appear to be the vital symptom of SARS Cov-2 which may improve at an interval of 3 weeks.

Keywords: Altered Taste; Altered Smell; Covid 19 Patients

References

  • Zhu N., et al. “A novel coronavirus from patients with pneumonia in China, 2019”. The New England Journal of Medicine 382 (2020): 727-733.
  • Zhou P., et al. “A pneumonia outbreak associated with a new coronavirus of probable bat origin”. Nature7798 (2020): 270-273.
  • Lu R., et al. “Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”. Lancet 10224 (2020): 565-574.
  • Mullol J., et al. “The sense of smell in chronic rhinosinusitis”. The Journal of Allergy and Clinical Immunology 145 (2020): 773-776.
  • Mullol J., et al. “Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study)”. BMJ Open 2 (2012): e001256.
  • Liu G., et al. “Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross- sectional study”. BMJ Open11 (2016): e013246.
  • Jaume F., et al. “Overuse of diagnostic tools and medications in acute rhinosinusitis in Spain: a population-based study (the PROSINUS study)”. BMJ Open1 (2018): e018788.
  • Butowt R and Bilinska K. “SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection”. ACS Chemical Neuroscience9 (2020): 1200-1203.
  • Bilinska K., et al. “Expression of the SARS- CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium: identification of cell types and trends with age”. ACS Chemical Neuroscience11 (2020): 155-162.
  • Xu H., et al. “High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa”. International Journal of Oral Science1 (2020): 8.
  • Cheng HY., et al. “Contact tracing assessment of COVID-19 transmission dynamics in Taiwan and risk at different exposure periods before and after symptom onset”. JAMA Internal Medicine (2020).
  • Mao L., et al. “Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China”. JAMA Neurology6 (2020): 1-9.
  • Giacomelli A., et al. “Self- reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study”. Clinical Infectious Diseases15 (2020): 889- 890.
  • Lechien JR., et al. “Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study”. European Archives of Oto-Rhino-Laryngology8 (2020): 2251-2261.
  • Song J., et al. “Self- reported taste and smell disorders in patients with COVID-19: distinct features in China”. Asian Journal Clinical and Experimental Otorhinolaryngology (2020).
  • Izquierdo-Domínguez A., et al. “Smell and taste dysfunctions in COVID-19 are associated with younger age in ambulatory settings - a multicenter cross-sectional study”. The Journal of Investigational Allergology and Clinical Immunology (2020).
  • Moein ST., et al. “Smell dysfunction: a biomarker for COVID- 19”. International Forum of Allergy and Rhinology 10.8 (2020): 944-950.
  • Al-Zaidi HMH and Badr HM. “Incidence and recovery of smell and taste dysfunction in COVID-19 positive patients”. The Egyptian Journal of Otolaryngology 1 (2020).
  • Klopfenstein T., et al. “New loss of smell and taste: Uncommon symptoms in COVID-19 patients on Nord Franche-Comte cluster, France”. International Journal of Infectious Diseases 100 (2020): 117-122.
  • Horvath L., et al. “Smell and taste loss in COVID-19 patients: assessment outcomes in a Victorian population”. Acta Oto-Laryngologica3 (2020): 299-302.
  • Lee Y., et al. “Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients”. Journal of Korean Medical Science18 (2020).
  • Hummel T., et al. “Position paper on olfactory dysfunction”. Rhinology Supplement 54 (2017): 1-30.
  • Citation

    Citation: Rashmi Nambiar., et al. “Etiopathogenesis and Prognosis of Altered Taste and Smell Sensation in Covid 19 Patients". Acta Scientific Otolaryngology 3.9 (2021): 09-12.

    Copyright

    Copyright: © 2021 Rashmi Nambiar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




    Metrics

    Acceptance rate34%
    Acceptance to publication20-30 days
    Impact Factor0.871

    Indexed In







    News and Events


    • Certification for Review
      Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
    • Submission Timeline for Upcoming Issue
      The last date for submission of articles for regular Issues is April 30th, 2024.
    • Publication Certificate
      Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
    • Best Article of the Issue
      The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
    • Welcoming Article Submission
      Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

    Contact US