Bo-Nien Chen1,3*, Chih-Yung Yang1 and Shiuan-Li Wey2
1Department of Otolaryngology-Head and Neck Surgery, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan
2Department of Pathology, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan
3Mackay Medical College, New Taipei, Taiwan
*Corresponding Author: Bo-Nien Chen, Department of Otolaryngology-Head and Neck Surgery, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan.
Received: June 30, 2021; Published: July 08, 2021
Objectives: Small cell neuroendocrine carcinoma (SCNEC) of the palatine tonsil is extremely rare, highly invasive, and associated with poor prognosis. Herein, we present an extremely rare case of SCNEC of the palatine tonsil after concurrent chemoradiotherapy (CCRT) for laryngeal cancer. We also provide a brief review of its clinicopathological characteristics and treatment modalities.
Methods: A 66-year-old Taiwanese woman visited our hospital with a 2-week history of left-sided sore throat. She had a history of laryngeal cancer treated with CCRT 5 years ago. Asymmetric enlargement of the left palatine tonsil with extensive ulceration was noted. Biopsy of the left palatine tonsil was performed, and SCNEC was diagnosed. The patient subsequently underwent surgical intervention (wide excision of the left palatine tonsil and left supraomohyoid neck dissection) and adjuvant chemotherapy.
Results: The patient tolerated the treatment well and symptoms resolved. Tumor recurrence was not observed in follow-up magnetic resonance imaging after therapy at the 12-month follow-up time point, and the patient has resumed a normal life.
Conclusion: This report highlights the importance of considering the effect of CCRT on SCNEC occurrence and expands the spectrum of reported radiation-induced neoplasms in the head and neck region. It is critical for clinicians to be aware of this extremely rare and highly invasive malignancy.
Keywords: Small Cell Neuroendocrine Carcinoma; Concurrent Chemoradiotherapy; Postradiation Neoplasia; Tonsillar Malignancy
Citation: Bo-Nien Chen., et al. “Small Cell Neuroendocrine Carcinoma of the Palatine Tonsil After Concurrent Chemoradiotherapy for Laryngeal Cancer: A Rare Case Report".Acta Scientific Otolaryngology 3.8 (2020): 54-57.
Copyright: © 2020 Bo-Nien Chen., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.