Bo-Nien Chen^1,2*

¹Department of Otolaryngology-Head and Neck Surgery, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan
²Mackay Medical College, New Taipei, Taiwan

*Corresponding Author: Bo-Nien Chen, Department of Otolaryngology-Head and Neck Surgery, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan.

Received: June 30, 2021; Published: July 08, 2021

Abstract

Objectives: Sinonasal inverted papillomas (SNIPs) are benign and account for 0.5%-7% of sinonasal tumors. However, SNIPs have the potential for recurrence and malignant transformation. The most common histologic type of malignant transformation of SNIPs is squamous cell carcinoma, and it is rarely associated with other pathological types of malignancy. Herein, we present a unique case of nasal-type natural killer (NK)/T-cell lymphoma occurring at the site from which a SNIP was previously resected.

Methods: A 58-year-old male nonsmoker had a left SNIP and underwent tumor excision by the endoscopic approach. Postoperatively, SNIP recurrence was not observed in routine follow-up. Thirteen years later, at the age of 71 years, he reported blood-tinged discharge from the left nose for 1 month and was diagnosed with nasal-type NK/T-cell lymphoma occurring at the site from which the SNIP was previously resected. He subsequently underwent tumor excision by the endoscopic approach and adjuvant concurrent chemoradiotherapy (CCRT).

Results: The patient tolerated treatment for nasal-type NK/T-cell lymphoma well. Recurrence of nasal-type NK/T-cell lymphoma was not observed during 30 months of follow-up after therapy.

Conclusion: Based on our research, this is the first reported case of nasal-type NK/T-cell lymphoma occurring at the site from which a SNIP was previously resected. In this case, awareness and early diagnosis, followed by endoscopic excision and adjuvant CCRT, provided good treatment results. This report expands the spectrum of reported SNIP-associated malignancy and emphasizes the importance of considering the malignant transformation of SNIPs and close, prolonged (preferably life-long) follow-up.

Keywords: Nasal-type Natural Killer/T-cell Lymphoma; Sinonasal Inverted Papilloma; Endoscopic Surgery; Concurrent Chemoradiotherapy

References

1. Wang MJ and Noel JE. “Etiology of sinonasal inverted papilloma: A narrative review”. World Journal of Otorhinolaryngology – Head and Neck Surgery 3 (2017): 54-58.
2. Lisan Q., et al. “Sinonasal inverted papilloma: From diagnosis to treatment”. European Annals of Oto-rhino-laryngology, Head and Neck 133 (2016): 337-341.
3. Tsou YA., et al. “Evaluation of correlation of cell cycle proteins and Ki-67 interaction in paranasal sinus inverted papilloma prognosis and squamous cell carcinoma transformation”. Biomed Research International 2014 (2014): 634945.
4. Sun Q., et al. “Advances in recurrence and malignant transformation of sinonasal inverted papillomas”. Oncology Letter 13 (2017): 4585-4592.
5. Yu HX and Liu G. “Malignant transformation of sinonasal inverted papilloma: A retrospective analysis of 32 cases”. Oncology Letter 8 (2014): 5.
6. Roy AD., et al. “NK/T cell lymphoma with inverted papilloma: A rare coexistence”. Australasian Medical Journal 7 (2014): 318-322.
7. Jalilvand S., et al. “The prevalence of human papillomavirus infection in Iranian patients with sinonasal inverted papilloma”. Journal of the Chinese Medical Association 79 (2016): 137-140.
8. Bugter O., et al. “Surgical management of inverted papilloma; a single-center analysis of 247 patients with long follow-up”. Journal of Otolaryngology - Head and Neck Surgery 46 (2017): 67.
9. Udager AM., et al. “High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal Papilloma”. Cancer Research 75 (2015): 2600-2606.
10. Singh G., et al. “Intestinal Type Adenocarcinoma from Inverted Papilloma: A Rare Recurrence”. Journal of Clinical and Diagnostic Research 10 (2016): Ed12-ed13.

Citation

Citation: Bo-Nien Chen. “Nasal-type Natural Killer/T-cell Lymphoma Occurring at the Site from Which a Sinonasal Inverted Papilloma was Previously Resected: A Rare Case Report".Acta Scientific Otolaryngology 3.8 (2020): 47-53.

Copyright

Copyright: © 2020 Bo-Nien Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.