Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 2 Issue 12

Determining the Relation between PET/CT and Staging in Larynx Carcinoma

Doğan Çakan1* and Muhammet Gazi Yildiz2

1Taksim Training and Research Hospital, Turkey
2Kahramanmaraş Sütçü Imam University Medicine School, Turkey

*Corresponding Author: Doğan Çakan, Taksim Training and Research Hospital, Turkey.

Received: October 16, 2020; Published: December 28, 2020

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Abstract

Purpose: The purpose of this study is to determine the relation between the positron emission tomography/computed tomography (PET/CT) findings and post-operative pathology findings, which is a guiding characteristic for staging in patients with larynx cancer.

Materials and Methods: In order to evaluate the PET/CT in terms of diagnostics, preoperative PET/CT was applied to the patients who received laryngectomy ± neck dissection in 2013 - 2015 period. The specimens were examined in pathological terms, and the relation between the preoperative PET/CT and pathology findings of the tumor was investigated. The statistical analysis of the data was made with the NCSS 2007 computer program.

Results: The mean age of the patients who were included in the study was determined as 62, and the gender discrimination was as follows; 47 males and 3 females. A statistically significant difference was determined in the PET/CT (Mass - SUVmax) levels of the different groups of T (TNM) staging (p < 0.05); in which, the PET/CT (Mass-SUVmax) levels of the T4 subgroup were higher than those of T1-2 subgroups at a significant level (p = 0.015). Considering the tumor differentiation in histopathology, no statistically significant differences were detected between the PET-CT (Mass -SUVmax) levels of the tumors with various differentiations (p > 0.05).

Conclusion: The imaging methods used in larynx staging and in determining the treatment plan are inadequate. The use of PET/CT may change the proper surgical planning in terms of the staging of the disease.

Keywords: Laryngectomy; Laryngeal Neoplasms; Lymphatic Metastasis; Neck Dissection; Neoplasm Staging; PET-CT

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References

  1. Castelijns JA. “Diagnostic radiology of head and neck oncology”. Current Opinion on Oncology3 (1991): 512-518.
  2. Kaya S. “Larynx Hastalıkları”. Ankara: Bilimsel Tıp Yay Ocak (2002): 539-716.
  3. Özlügedik S and Ünal A. “Baş boyun kanserlerinde epidemiyoloji ve risk faktörleri”. KBB Baş Boyun Cerrahisi’nde Güncel Yaklaşım. 1.3 (2005): 51-56.
  4. Yousenm DM., et al. “Resectability issues with head and neck cancer”. AJNR American Journal of Neuroradiology10 (2006).2024-2036.
  5. Yüksel M and Kalaycı G. “Göğüs Cerrahisi”. Bilmedya Grup (2001): 291-302.
  6. Tatar G., et al. “The value of whole-body contrast-enhanced 18F-FDG PET/CT imaging in the diagnosis and staging of patients with laryngeal carcinoma”. Nuclear Medicine Communications4 (2018): 334-342.
  7. American Joint Committee on Cancer. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer International Publishing (2017).
  8. Archer CR and Yeager VL. “Computed tomography of laryngeal cancer with histopathological correlation”. Laryngoscope 92 (1982): 1173-1180.
  9. Liao LJ., et al. “Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck-a meta-analysis comparing different imaging modalities”. BMC Cancer 12 (2012): 236.
  10. Jemal A., et al. “Global cancer statistics”. CA: A Cancer Journal for Clinicians 61 (2011): 69.
  11. Kumar V., et al. “Pathologic basis of disease, 7th edition”. China: Elsevier (2005): 786-787.
  12. Kim JK., et al. “Evaluation of 18F-FDG PET/CT and CT/MRI with histopathologic correlation in patients undergoing central compartment neck dissection for squamous cell carcinoma of the larynx, hypopharynx, and esophagus”. Oral Oncology 49 (2013) 449-453.
  13. Ferlito A., et al. “Prognostic value of Delphian lymph node metastasis from laryngeal and hypopharyngeal cancer”. Acta Otolaryngology 122 (2002): 456-457.
  14. Demirci U., et al. “The Nodal Standard Uptake Value (SUV) as a Prognostic Factor in Head and Neck Squamous Cell Cancer”. Asian Pacific Journal of Cancer Prevention 12 1817-1820.
  15. Haerle SK., et al. “Is there a correlation between 18F-FDG-PET standardized uptake value, T-classification, histological grading and the anatomic subsites in newly diagnosed squamous cell carcinoma of the head and neck?” European Archives of Otorhinolaryngology10 (2010): 1635-1640.
  16. Suzuki K., et al. “Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer: does the standardized uptake value predict treatment outcome?” Japanese Journal of Radiology 6 (2009): 237-242.
  17. Laubenbacher C., et al. “Comparison of fluorine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas”. The Journal of Nuclear Medicine10 (1995): 1747-1757.
  18. Abgral R., et al. “Prognostic value of volumetric parameters measured by 18F-FDG PET/CT in patients with head and neck squamous cell carcinoma”. European Journal of Nuclear Medicine and Molecular Imaging 4 (2014): 659-667.
  19. Kim SY., et al. “Evaluation of 18F-FDG PET/CT and CT/MRI with histopathologic correlation in patients undergoing salvage surgery for head and neck squamous cell carcinoma”. Annals of Surgery Oncology9 (2011): 2579-2584.
  20. Nakajo M., et al. “FDG PET/CT and diffusion-weighted imaging of head and neck squamous cell carcinoma: comparison of prognostic significance between primary tumor standardized uptake value and apparent diffusion coefficient”. Clinical Nuclear Medicine 5 (2012): 475-480.
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Citation

Citation: Doğan Çakan and Muhammet Gazi Yildiz. “Determining the Relation between PET/CT and Staging in Larynx Carcinoma". Acta Scientific Otolaryngology 3.1 (2020): 32-38.




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