Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Research Article Volume 2 Issue 12

Using Gap-induced Inhibition of the Post-auricular Muscle Response as an Objective Measure of Tinnitus in Humans

Caroline A Wilson1,2, Joel I Berger1, Jessica de Boer1,2, Magdalena Sereda2,3, Alan R Palmer1,2, Deborah A Hall2,3,4,5 and Mark N Wallace1,2*

1Medical Research Council Institute of Hearing Research, School of Medicine, University of Nottingham, Nottingham, UK
2Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK
3National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Ropewalk House, Nottingham, UK
4Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham, UK
5University of Nottingham Malaysia, Jalan Broga, Selangor Darul Ehsan, Malaysia

*Corresponding Author: Mark N Wallace, Division of Clinical Neuroscience, University Park, UK.

Received: September 22, 2020; Published: November 27, 2020



  A widely used method for detecting tinnitus in rodents is the gap pre-pulse inhibition of the acoustic startle (GPIAS). One variant uses the Preyer reflex to assess the startle response and a component of this can be measured as a small muscle potential generated by the post-auricular muscle reflex (PAMR). The question was whether the GPIAS method could also be used to identify tinnitus in humans using the PAMR response. We recruited 19 participants with chronic tinnitus and 18 age-matched controls, but 12 tinnitus participants were unable to contribute data to the final result due to hyperacusis or lack of a PAMR. A majority of those tinnitus participants with a detectable PAMR showed some evidence of GPIAS (71%, 5/7). In the control group, most showed a PAMR response (67%, 12/18) and most of these demonstrated GPIAS (67%, 8/12). Our stimulus parameters were not completely optimal for showing a PAMR response so, with further refinement it may be possible to use the PAMR response and GPIAS as an objective method for demonstrating tinnitus in humans.

Keywords: Gap Induced Pre-pulse Inhibition; Preyer Reflex; Acoustic Startle Reflex; Eyeblink Reflex; Humans; Personalised Medicine



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Citation: Wilson., et al. “Using Gap-induced Inhibition of the Post-auricular Muscle Response as an Objective Measure of Tinnitus in Humans". Acta Scientific Otolaryngology 2.12 (2020): 40-52.


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