Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Case Report Volume 2 Issue 11

IgG4-Related Disease: A Case Report of a Massive Presentation Leading to the Diagnosis of B-Cell Lymphoma

Solano Nicolás1,2, Ramos Salomón1,2, Rivera Ejusmar1,2* and Rios Elvia1,2

1Oral and Maxillofacial Surgery Unit, Servicio Autónomo Hospital Universitario de Maracaibo, Venezuela
2Oral Surgery Postgraduate Residency Training Program, La Universidad Del Zulia, Maracaibo, Venezuela

*Corresponding Author: Rivera Ejusmar, Oral and Maxillofacial Surgery Unit, Servicio Autónomo Hospital Universitario de Maracaibo, Venezuela.

Received: July 18, 2020; Published: October 28, 2020



  Immunoglobulin G4 related disease is a recently described entity with a broad spectrum of clinical manifestations. It is characterized for being a fibroinflammatory systemic condition involving a dense infiltrate of IgG4 rich-plasma cells. The organs most commonly affected by this pathology are the salivary and lacrimal glands. To establish the diagnosis, the clinician must follow certain criteria, such as a thorough physical examination in order to find the localized inflammatory characteristics in one or multiple organs, an hematologic test showing high levels of serum IgG4 (> 135 mg/dl) and a histopathological examination of the inflammatory lesions. Until now, glucocorticoids have been the main treatment for this condition due to its efficacy and affordability; however, if no positive response is found when using this treatment modality, it is indicative that the diagnosis may not be the correct one.

Keywords: IgG4; IgG4 Related Disease; Salivary Glands; B-Cell Lymphoma; Lacrimal Glands



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Citation: Rivera Ejusmar., et al. “IgG4-Related Disease: A Case Report of a Massive Presentation Leading to the Diagnosis of B-Cell Lymphoma". Acta Scientific Otolaryngology 2.11 (2020): 29-33.


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