Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Case Report Volume 2 Issue 11

IgG4-Related Disease: A Case Report of a Massive Presentation Leading to the Diagnosis of B-Cell Lymphoma

Solano Nicolás1,2, Ramos Salomón1,2, Rivera Ejusmar1,2* and Rios Elvia1,2

1Oral and Maxillofacial Surgery Unit, Servicio Autónomo Hospital Universitario de Maracaibo, Venezuela
2Oral Surgery Postgraduate Residency Training Program, La Universidad Del Zulia, Maracaibo, Venezuela

*Corresponding Author: Rivera Ejusmar, Oral and Maxillofacial Surgery Unit, Servicio Autónomo Hospital Universitario de Maracaibo, Venezuela.

Received: July 18, 2020; Published: October 28, 2020

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Abstract

  Immunoglobulin G4 related disease is a recently described entity with a broad spectrum of clinical manifestations. It is characterized for being a fibroinflammatory systemic condition involving a dense infiltrate of IgG4 rich-plasma cells. The organs most commonly affected by this pathology are the salivary and lacrimal glands. To establish the diagnosis, the clinician must follow certain criteria, such as a thorough physical examination in order to find the localized inflammatory characteristics in one or multiple organs, an hematologic test showing high levels of serum IgG4 (> 135 mg/dl) and a histopathological examination of the inflammatory lesions. Until now, glucocorticoids have been the main treatment for this condition due to its efficacy and affordability; however, if no positive response is found when using this treatment modality, it is indicative that the diagnosis may not be the correct one.

Keywords: IgG4; IgG4 Related Disease; Salivary Glands; B-Cell Lymphoma; Lacrimal Glands

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References

  1. Agazzoni M., et al. “Enfermedad relacionada con IgG4: un desafío diagnóstico”. Hematología1 (2017): 71-76.
  2. Tsuchida S., et al. “Oral and maxillofacial symptoms of patients with IgG4-related disease: The meaning of a labial minor salivary gland biopsy”. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology5 (2018): 439-444.
  3. Navarro E., et al. “Espectro clínico de la enfermedad relacionada con IgG4”. Revista Colombiana de Reumatología 1 (2018): 69-74.
  4. Garcia C., et al. “Enfermedad relacionada con IgG4. A propósito de un caso”. Medicina paliativa 1 (2019): 35-37.
  5. Ardila O., et al. “Enfermedad relacionada con IgG4: revisión concisa de la literature”. Reumatología Clínica 3 (2017): 160-166.
  6. Tsubota K., et al. “Mikulicz´s disease and sjogren´s syndrome”. Investigative Ophthalmology and Visual Science 7 (2000): 1666-1673.
  7. Fernandez A., et al. “Treatment and outcomes in patients with IgG4-related disease using the IgG4 responder index”. Joint Bone Spine6 (2018): 721-726.
  8. Tang J., et al. “Biomarkers in IgG4-related disease: a systematic review”. Seminars in Arthritis and Rheumatism (2019): 1-6.
  9. Kouwenberg W., et al. “Inflammatory pseudotumour of the alveolar process of the maxilla as clinical manifestation of IgG4-related disease: a case report and literature review”. International Journal of Oral and Maxillofacial Surgery 6 (2020): 722-725.
  10. Zachary S., et al. “Immunoglobulin G4-related disease”. Clinics in Chest Medicine (2019): 583-597.
  11. Sato Y., et al. “IgG4 producing marginal zone B-cell lymphoma”. International Journal of Hematology 4 (2008): 428-433.
  12. Yoh Zen. “Pathological characteristic and diagnosis of IgG4-related disease”. La Presse Medicale1 (2020): 104014.
  13. Sanchez R., et al. “Review of IgG4-related disease”. Clinical Gastroenterology and Hepatology 10 (2019): 638-647.
  14. Wick M and O`Malley D. “Lymphadenopathy associated with IgG4-related disease: Diagnosis and differential diagnosis”. Seminars in Diagnostic Pathology 1 (2018): 61-66.
  15. Jespal G., et al. “Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland”. Human Pathology 40 (2009): 881-886.
  16. Igawa T., et al. “IgG4-producing lymphoma arising in a patient with IgG4-related disease”. Medical Molecular Morphology 4 (2016): 243-249.
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Citation

Citation: Rivera Ejusmar., et al. “IgG4-Related Disease: A Case Report of a Massive Presentation Leading to the Diagnosis of B-Cell Lymphoma". Acta Scientific Otolaryngology 2.11 (2020): 29-33.




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