Abstract

  Immunoglobulin G4 related disease is a recently described entity with a broad spectrum of clinical manifestations. It is characterized for being a fibroinflammatory systemic condition involving a dense infiltrate of IgG4 rich-plasma cells. The organs most commonly affected by this pathology are the salivary and lacrimal glands. To establish the diagnosis, the clinician must follow certain criteria, such as a thorough physical examination in order to find the localized inflammatory characteristics in one or multiple organs, an hematologic test showing high levels of serum IgG4 (> 135 mg/dl) and a histopathological examination of the inflammatory lesions. Until now, glucocorticoids have been the main treatment for this condition due to its efficacy and affordability; however, if no positive response is found when using this treatment modality, it is indicative that the diagnosis may not be the correct one.

Keywords: IgG4; IgG4 Related Disease; Salivary Glands; B-Cell Lymphoma; Lacrimal Glands

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Citation

Citation: Rivera Ejusmar., et al. “IgG4-Related Disease: A Case Report of a Massive Presentation Leading to the Diagnosis of B-Cell Lymphoma". Acta Scientific Otolaryngology 2.11 (2020): 29-33.

Copyright

Copyright: © 2020 Rivera Ejusmar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.