Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Letter to Editor Volume 2 Issue 11

Vitamin C against SARS-CoV-2: A Hope in the Covid-19

Muhammad Torequl Islam*

Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, Bangladesh.

*Corresponding Author: Muhammad Torequl Islam, Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, Bangladesh.

Received: September 18, 2020; Published: October 16, 2020

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   Vitamin C (also called ascorbic acid, AA), an essential micronutrient for humans [1]. It’s deficiency is linked to impaired immunity [2], thereby, increases the risk of infection [3]. It acts against oxidative stress due to its strong antioxidant capacity. As a cofactor this vitamin helps in the biosynthesis and gene regulation of various enzymes [1]. It imparts immune defense through innate and adaptive immune responses [2]. It strengthens epithelial barrier function, thereby, resists the pathogenic invasion in our body [3]. The phagocytic cells (e.g. neutrophils) accumulate this vitamin, results in anti-microbial activity [1]. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage [4]. Moreover, it has many important roles in our skin health [5]. It enhances the differentiation and proliferation of lymphocytes (e.g., B and T cells) [6]. AA can be used to prevent and/or treat both local and systemic infections [3,7]. Therefore, adequate dietary intake of this vitamin is required for proper functioning of cells and tissues in our body [1].

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References

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  14. Kaul D., et al. “Importance of LXR-α transcriptome in the modulation of innate immunity”. Molecular and Cellular Biochemistry 292 (2006): 53-57.
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  17. Carr A and Frei B. “Does vitamin C act as a pro-oxidant under physiological conditions?” FASEB Journal 13 (1999): 1007-1024.
  18. Uozaki M., et al. “Antiviral effects of dehydroascorbic acid”. Experimental and Therapeutic Medicine 6 (2010): 983-986.
  19. Jöbsis RQ., et al. “Hydrogen peroxide in breath condensate during a common cold”. Mediators of Inflammation 10 (2001): 351-354.
  20. Yeo SJ., et al. “Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells”. Archives of Virology 144 (1999): 1361-1370.
  21. Hernández Guerrero CA., et al. “Vitamin C decreases MMP-9 synthesis induced by hydrogen peroxide in an in vitro chorioamniotic membrane model”. Ginecologia y obstetricia de Mexico 74 (2006): 3-12.
  22. Wybieralska E., et al. “Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells”. Cellular and Molecular Biology Letters 13 (2008): 103-111.
  23. Gorton HC and Jarvis K. “The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections”. Journal of Manipulative and Physiological Therapeutics 22 (1999): 530-533.
  24. Kimbarowski JA., et al. “Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza”. Dtsch Gesundheitsw 22 (1967): 2413-2418.
  25. Ulasli M., et al. “The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family”. Molecular Biology Reports 41 (2014): 1703-1711.
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Citation

Citation: Muhammad Torequl Islam. "Vitamin C against SARS-CoV-2: A Hope in the Covid-19". Acta Scientific Otolaryngology 2.11 (2020): 20-22.




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