Acta Scientific Otolaryngology (ASOL) (ISSN: 2582-5550)

Letter to Editor Volume 2 Issue 11

Vitamin C against SARS-CoV-2: A Hope in the Covid-19

Muhammad Torequl Islam*

Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, Bangladesh.

*Corresponding Author: Muhammad Torequl Islam, Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, Bangladesh.

Received: September 18, 2020; Published: October 16, 2020

×

   Vitamin C (also called ascorbic acid, AA), an essential micronutrient for humans [1]. It’s deficiency is linked to impaired immunity [2], thereby, increases the risk of infection [3]. It acts against oxidative stress due to its strong antioxidant capacity. As a cofactor this vitamin helps in the biosynthesis and gene regulation of various enzymes [1]. It imparts immune defense through innate and adaptive immune responses [2]. It strengthens epithelial barrier function, thereby, resists the pathogenic invasion in our body [3]. The phagocytic cells (e.g. neutrophils) accumulate this vitamin, results in anti-microbial activity [1]. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage [4]. Moreover, it has many important roles in our skin health [5]. It enhances the differentiation and proliferation of lymphocytes (e.g., B and T cells) [6]. AA can be used to prevent and/or treat both local and systemic infections [3,7]. Therefore, adequate dietary intake of this vitamin is required for proper functioning of cells and tissues in our body [1].

×

References

  1. Padayatty SJ and Levine M. “Vitamin C physiology: the known and the unknown and Goldilocks”. Oral Disease6 (2016): 463-493.
  2. Carr AC and Maggini S. “Vitamin C and Immune Function”. Nutrients 11 (2017): 1211.
  3. Hemilä H. “Vitamin C and Infections”. Nutrients4 (2017): 339.
  4. Liugan M and Carr AC. “Vitamin C and Neutrophil Function: Findings from Randomized Controlled Trials”. Nutrients9 (2019): 2102.
  5. Pullar JM., et al. “The Roles of Vitamin C in Skin Health”. Nutrients 8 (2017): 866.
  6. Manning J., et al. “Vitamin C Promotes Maturation of T-Cells”. Antioxide Redox Signal17 (2013): 2054-2067.
  7. Garaiova I., et al. “Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study”. European Journal of Clinical Nutrition 3 (2015): 373-379.
  8. Yakoot M and Salem A. “Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold”. International Journal of General Medicine 4 (2011): 45-51.
  9. Banerjee D and Kaul D. “Combined inhalational and oral supplementation of ascorbic acid may prevent influenza pandemic emergency: A hypothesis”. Nutrition1 (2010): 128-132.
  10. Kim Y., et al. “Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection”. Immune Netw2 (2013): 70-74.
  11. Bissell MJ., et al. “Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus”. Proceedings of the National Academy of Sciences of the United States of America 5 (1980): 2711-2715.
  12. Harakeh S., et al. “Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells”. Proceedings of the National Academy of Sciences of the United States of America 87 (1990): 7245-7249.
  13. Kaul D and Baba MI. “Genomic effect of vitamin ‘C’ and statins within human mononuclear cells involved in atherogenic process”. European Journal of Clinical Nutrition 59 (2005): 978-981.
  14. Kaul D., et al. “Importance of LXR-α transcriptome in the modulation of innate immunity”. Molecular and Cellular Biochemistry 292 (2006): 53-57.
  15. Wang H., et al. “c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle”. Oncogene 27 (2008): 1905-1915.
  16. Furuya A., et al. “Antiviral effects of ascorbic and dehydroascorbic acids in vitro”. International Journal of Molecular Medicine 22 (2008): 541-545.
  17. Carr A and Frei B. “Does vitamin C act as a pro-oxidant under physiological conditions?” FASEB Journal 13 (1999): 1007-1024.
  18. Uozaki M., et al. “Antiviral effects of dehydroascorbic acid”. Experimental and Therapeutic Medicine 6 (2010): 983-986.
  19. Jöbsis RQ., et al. “Hydrogen peroxide in breath condensate during a common cold”. Mediators of Inflammation 10 (2001): 351-354.
  20. Yeo SJ., et al. “Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells”. Archives of Virology 144 (1999): 1361-1370.
  21. Hernández Guerrero CA., et al. “Vitamin C decreases MMP-9 synthesis induced by hydrogen peroxide in an in vitro chorioamniotic membrane model”. Ginecologia y obstetricia de Mexico 74 (2006): 3-12.
  22. Wybieralska E., et al. “Ascorbic acid inhibits the migration of walker 256 carcinosarcoma cells”. Cellular and Molecular Biology Letters 13 (2008): 103-111.
  23. Gorton HC and Jarvis K. “The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections”. Journal of Manipulative and Physiological Therapeutics 22 (1999): 530-533.
  24. Kimbarowski JA., et al. “Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza”. Dtsch Gesundheitsw 22 (1967): 2413-2418.
  25. Ulasli M., et al. “The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family”. Molecular Biology Reports 41 (2014): 1703-1711.
×

Citation

Citation: Muhammad Torequl Islam. "Vitamin C against SARS-CoV-2: A Hope in the Covid-19". Acta Scientific Otolaryngology 2.11 (2020): 20-22.




Metrics

Acceptance rate34%
Acceptance to publication20-30 days
Impact Factor0.871

Indexed In







News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US