Abstract

Objectives: To study the expression of Matrix metalloproteinases 2 and 9 in laryngeal squamous cell carcinoma and their correlation with short term outcome.

Study Design: In a prospective study of 15 patients with LSCC hospitalized in a tertiary center, RT-PCR was used to examine the expression of MMP-2 and MMP-9 in tissue samples post-surgery and results were compared to clinicopathological features and prognosis.

Results: The positive expression of MMP-2 and MMP-9 in patients with LSCC was 86.66% whereas 13.33% showed decrease. MMP-2 and MMP-9 were increased in patient with Stage IV A (1 patient) and 85.7% of patients (12 patients) in Stage III showed increase in MMP-2 and MMP-9 and 14.3% (2 patients) showed decrease. Patients with metastatic lymph nodes showed 100% increase in MMP-2 and MMP-9 whereas patients with non-metastatic lymph nodes showed 92.3% increase and 7.7% decrease in MMP-2 and MMP-9. No significant association was found between nodal disease and stage and mmp-2 and mmp-9 (p = 0.551 and 0.685 resp.). The association between decrease in MMP-2 and MMP-9 to well differentiated and increase in MMP-2 and MMP-9 to poor differentiation was found to be significant (p = 0.03). The association between MMP-2 and MMP-9 upregulation and recurrence in follow up was not found to be statistically significant (p = 0.685).

Conclusion: The results of the present study indicate that the expression of both MMP-2 and MMP-9 are up-regulated in laryngeal cancers with 100% survival in shorter outcome of 6 months.

Keywords: MMP-2; MMP-9; Laryngeal Carcinoma

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Citation

Citation: Suman Paudel., et al. “Expression of Matrix Metalloproteinases 2 and 9 in Laryngeal Carcinoma and it’s Correlation to Short Term Outcome". Acta Scientific Otolaryngology 2.6 (2020): 04-09.

Copyright

Copyright: © 2020 Suman Paudel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.