Acta Scientific Otolaryngology (ASOL)

Research Article Volume 2 Issue 6

Expression of Matrix Metalloproteinases 2 and 9 in Laryngeal Carcinoma and it’s Correlation to Short Term Outcome

Suman Paudel1*, Jaimanti Bakshi2, Naresh Kumar Panda2, Sushmita Ghoshal3, Madhu Khullar4, Roshan Kumar Verma2 and Amanjit Bal5

1Department of ENT, Head and Neck Surgery, Chitwan Medical College and Teaching Hospital, Bharatpur, Nepal
2Professor, Department of Otolaryngology, Head and Neck Surgery, PGIMER, Chandigarh, India
3Professor, Department of Radiotherapy, PGIMER, Chandigarh, India
4Professor, Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, India
5Professor, Department of Histopathology, PGIMER, Chandigarh, India

*Corresponding Author: Suman Paudel, Assistant Professor, Department of ENT, Head and Neck Surgery, Chitwan Medical College and Teaching Hospital, Bharatpur, Nepal.

Received: March 09, 2020; Published: May 07, 2020

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Abstract

Objectives: To study the expression of Matrix metalloproteinases 2 and 9 in laryngeal squamous cell carcinoma and their correlation with short term outcome.

Study Design: In a prospective study of 15 patients with LSCC hospitalized in a tertiary center, RT-PCR was used to examine the expression of MMP-2 and MMP-9 in tissue samples post-surgery and results were compared to clinicopathological features and prognosis.

Results: The positive expression of MMP-2 and MMP-9 in patients with LSCC was 86.66% whereas 13.33% showed decrease. MMP-2 and MMP-9 were increased in patient with Stage IV A (1 patient) and 85.7% of patients (12 patients) in Stage III showed increase in MMP-2 and MMP-9 and 14.3% (2 patients) showed decrease. Patients with metastatic lymph nodes showed 100% increase in MMP-2 and MMP-9 whereas patients with non-metastatic lymph nodes showed 92.3% increase and 7.7% decrease in MMP-2 and MMP-9. No significant association was found between nodal disease and stage and mmp-2 and mmp-9 (p = 0.551 and 0.685 resp.). The association between decrease in MMP-2 and MMP-9 to well differentiated and increase in MMP-2 and MMP-9 to poor differentiation was found to be significant (p = 0.03). The association between MMP-2 and MMP-9 upregulation and recurrence in follow up was not found to be statistically significant (p = 0.685).

Conclusion: The results of the present study indicate that the expression of both MMP-2 and MMP-9 are up-regulated in laryngeal cancers with 100% survival in shorter outcome of 6 months.

Keywords: MMP-2; MMP-9; Laryngeal Carcinoma

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Citation

Citation: Suman Paudel., et al. “Expression of Matrix Metalloproteinases 2 and 9 in Laryngeal Carcinoma and it’s Correlation to Short Term Outcome". Acta Scientific Otolaryngology 2.6 (2020): 04-09.




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