Abstract

  Biphenotypic sinonasal sarcoma is a newly described tumour of nose and paranasal sinuses containing neural and muscle tissue together in the tumour tissue. There are almost 68 different types of tumours in the Sinonasal tract. This tumour is in addition to that. A 60 year old female with history of nose block of both sides of 8 years duration, and a visible mass in the right nasal cavity, since 2 years presented to us one month back. There was no obvious features of malignancy. CT PNS showed large heterogeneous calcified mass showing enhancement in the right nasal cavity eroding the nasal septum and reaching left side pushing it. Histopathology showed a neoplasm covered partly by partly by psuedostratified columnar epithelium and partly by squamous epithelium. Neoplasm was cellular and composed of spindle cells with spindle/oval/wavy nuclei arranged in in sheets It was seen invading the adjacent bone. Histopathology was suggestive of low grade sarcoma possibly Biphenotypic sinonasal sarcoma. Immunohistochemistry showed vimentin and S100 positivity, SMA was focally positive. Betacatenin showed cytoplasmic granular positivity, Ki 67 percentage of positive nuclei 2-3%, MyoD1 Negative and the final report was Biphenotypic sinonasal sarcoma. This neoplasm contained myogenic and nervous tissue together. Endoscopic excision of the tumour was done. She was advised Craniofacial resection for this low grade malignancy as it was dangerous to remove it endoscopically due to the close proximity with the cribriform plate.

Keywords: Biphenotypic Sinonasal Sarcoma; New Entities of Sinonasal Tract Tumours

References

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Citation

Citation: George MV., et al. “A Rare Case of Biphenotypic Sino-Nasal Sarcoma - Case Report and Review of Literature". Acta Scientific Otolaryngology 2.2 (2020): 24-26.

Copyright

Copyright: © 2020 George MV., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.