Bansari Upadhyay^1*, Debabrata Sarkar² and Ronak Chhaya²

¹Product Development Department, BioAni India Pvt. Ltd., India
²Research and Development Division, BioAni India Pvt. Ltd., India

*Corresponding Author: Bansari Upadhyay, Product Development Department, BioAni India Pvt. Ltd., India.

Received: August 19, 2026; Published: October 01, 2026

Ultra-processed foods (UPFs) have become a major component of modern food environments and are increasingly investigated as a potential determinant of metabolic disease. Within the NOVA classification, UPFs are industrial formulations made from food-derived substances and additives and are typically designed for convenience, long shelf life, intense palatability and rapid consumption. High intake is consistently associated in observational research with obesity, type 2 diabetes, cardiovascular disease and other adverse health outcomes, although the magnitude and causality of these associations vary across outcomes and study designs. A controlled inpatient randomized trial demonstrated that participants consumed substantially more energy and gained weight during an ultra-processed diet than during an unprocessed diet despite broadly matched presented macronutrient composition, supporting a plausible causal pathway through eating rate, energy density, palatability and satiety. More recent research has shifted attention toward the gut microbiome as a potential mechanistic bridge between food processing and metabolic dysfunction. UPF-rich dietary patterns can be characterized by low intact dietary fibre and altered food structure, together with exposure to emulsifiers, non-nutritive sweeteners, colours and other additives. These features may modify microbial community structure and function, short-chain fatty-acid production, bile-acid metabolism, intestinal mucus and barrier integrity, microbial-host signalling and low- grade systemic inflammation. However, direct human intervention evidence linking overall UPF exposure to microbiome-mediated metabolic disease remains limited, and effects of individual additives cannot automatically be generalized to all UPFs. This review examines the concept and classification of ultra-processing, nutritional and physicochemical characteristics of UPFs, evidence linking UPF exposure with metabolic health, and emerging mechanisms involving gut microbiome dysfunction, intestinal barrier disruption, inflammation and altered host metabolism. Current limitations, research priorities and practical implications for nutrition and public health are also discussed. The available evidence supports reducing reliance on UPFs while emphasizing minimally processed foods, dietary fibre and overall dietary quality, but it also highlights the need for well-controlled long-term human studies capable of separating processing effects from nutrient composition, energy intake and other correlated dietary factors.

Keywords: Ultra-Processed Foods; NOVA Classification; Metabolic Health; Obesity; Type 2 Diabetes; Insulin Resistance; Gut Microbiome; Dysbiosis; Intestinal Barrier; Inflammation; Short-Chain Fatty Acids; Food Additives

References

1. Monteiro CA., et al. “Ultra-processed foods: what they are and how to identify them”. Public Health Nutrition5 (2019): 936-941.
2. Monteiro CA., et al. “The UN Decade of Nutrition, the NOVA food classification and the trouble with ultra-processing”. Public Health Nutrition1 (2018): 5-17.
3. Lane MM., et al. “Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses”. BMJ 384 (2024): e077310.
4. Hall KD., et al. “Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake”. Cell Metabolism1 (2019): 67-77.e3.
5. Fiolet T., et al. “Consumption of ultra-processed foods and cancer risk: results from the NutriNet-Santé prospective cohort”. BMJ 360 (2018): k322.
6. Srour B., et al. “Ultra processed food consumption and risk of type 2 diabetes among participants of the NutriNet-Santé prospective cohort”. JAMA Internal Medicine2 (2020): 283-291.
7. Whelan K., et al. “Ultra-processed foods and food additives in gut health and disease”. Nature Reviews Gastroenterology and Hepatology 21 (2024): 406-427.
8. Brichacek AL., et al. “Ultra-Processed Foods: A Narrative Review of the Impact on the Human Gut Microbiome and Variations in Classification Methods”. Nutrients11 (2024): 1738.
9. Pagliai G., et al. “Consumption of ultra-processed foods and health status: a systematic review and meta-analysis”. British Journal of Nutrition3 (2021): 308-318.
10. Zinöcker MK and Lindseth IA. “The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease”. Nutrients3 (2018): 365.
11. Srour B., et al. “Ultra-processed food consumption and risk of cardiovascular diseases: prospective cohort evidence”. BMJ 365 (2019): l1451.
12. Lawrence MA and Baker PI. “Ultra-processed food and adverse health outcomes”. BMJ 365 (2019): l2289.
13. Chassaing B., et al. “Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome”. Gastroenterology3 (2022): 743-756.
14. Suez J., et al. “Artificial sweeteners induce glucose intolerance by altering the gut microbiota”. Nature 514 (2014): 181-186.
15. Monteiro CA., et al. “Impact of food ultra-processing on cardiometabolic health: definitions, evidence, and implications for dietary guidance”. Journal of the American Heart Association21 (2024): e035986.
16. Baker P., et al. “Ultra-processed foods and the nutrition transition: global, regional and national trends, food systems transformations and political economy drivers”. Obesity Review12 (2020): e13126.
17. Monteiro CA., et al. “Ultra-processed foods, diet quality, and health using the NOVA classification system”. Rome: Food and Agriculture Organization of the United Nations (2019).
18. Maki KA., et al. “Ultra-processed foods: increasing the risk of inflammation and immune dysregulation?” Nature Reviews Immunology 24 (2024): 453-454.
19. Capra BT., et al. “Ultra-processed food intake, gut microbiome, and glucose homeostasis in mid-life adults: background, design, and methods of a controlled feeding trial”. Contemporary Clinical Trials 137 (2024): 107427.
20. Deehan EC and Walter J. “The fiber gap and the disappearing microbiome: implications for human nutrition”. Trends in Endocrinology and Metabolism5 (2016): 239-242.
21. Fan Y and Pedersen O. “Gut microbiota in human metabolic health and disease”. Nature Reviews Microbiology 19 (2021): 55-71.
22. Adeshirlarijaney A and Gewirtz AT. “Considering gut microbiota in treatment of type 2 diabetes mellitus”. Gut Microbes3 (2020): 253-264.
23. Canfora EE., et al. “Short-chain fatty acids in control of body weight and insulin sensitivity”. Nature Reviews Endocrinology 11 (2015): 577-591.
24. Chassaing B., et al. “Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome”. Nature 519 (2015): 92-96.
25. Dicken SJ., et al. “Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial”. Nature Medicine 31 (2025): 3297-3308.

Citation

Citation: Bansari Upadhyay., et al. “Ultra-Processed Foods and Metabolic Health: From Food Processing to Gut Microbiome Dysfunction". Acta Scientific Medical Sciences 10.10 (2026): 24-34.

Copyright

Copyright: © 2026 Bansari Upadhyay., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.