Nayan Gajghate¹, Sumeet Tupe¹, Heena Buch² and Sanjay Chatterjee^3*

¹ Postgraduate Student, Department of General Surgery, Bombay Hospital, New Marine Lines, Mumbai, Maharashtra, India
² Intern, Bombay Hospital, New Marine Lines, Mumbai, Maharashtra, India

*Corresponding Author: Sanjay Chatterjee, Assistant Professor, Maharashtra University of Health Sciences, Nashik Postgraduate Teacher, Bombay hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

Received: December 01, 2025; Published: January 30, 2026

Abstract

Myoepithelial carcinoma (MC) is an uncommon malignant tumour arising primarily from salivary gland myoepithelial cells. It constitutes fewer than 1% of all salivary gland neoplasms, most of which are benign. Malignant myoepitheliomas may appear de novo or evolve from a pre-existing pleomorphic adenoma or benign myoepithelioma. Involvement of the buccal mucosa is exceptionally rare.

We report the case of a 36-year-old female presenting with a three-month history of a painful swelling in the right buccal mucosa. MRI suggested a malignant neoplastic lesion arising from the buccal mucosa.

Histopathological analysis showed a circumscribed spindle-cell lesion forming epithelioid nests. Immunohistochemistry demonstrated positivity for EMA, PanCK, P53, P40 and Calponin, with S-100 negativity and a low Ki-67 index (4–5%), confirming myoepithelial carcinoma.

Given its rarity and morphological heterogeneity, diagnosing MC is challenging. A high degree of clinical suspicion and confirmatory immunohistochemical profiling are crucial for accurate diagnosis.

Keywords: Myoepithelial Carcinoma; Minor Salivary Gland Tumour; Buccal Mucosa Tumour; Oral Malignancy

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Citation

Citation: Sanjay Chatterjee., et al. “A Curious Case of Buccal Mucosal Mass". Acta Scientific Medical Sciences 10.2 (2026): 64-68.

Copyright

Copyright: © 2026 Sanjay Chatterjee., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.