Madiha Ouchamch*, J Kouach, M Elhassani and K GUelzim

Experience of the Military Hospital Mohammed V rabat morroco University med V rabat morocco

*Corresponding Author: Madiha Ouchamch, Expérience the military hopitala mohammed V rabat morroco, University med V rabat morocco.

Received: October 13, 2025; Published: December 22, 2025

Abstract

The treatment for endometrial cancer is rapidly evolving with the development of molecular analysis and novel strategies. Surgical resection, cytotoxic chemotherapy, endocrine or hormonal treatment, and radiation have been the staples of treatment for decades. However, precision-based approaches for tumors are rapidly becoming part of these strategies.

For several years, around 420,242 people have been diagnosed with endometrial cancer. Among them, nearly 97,704 people die each year (Bray., et al. 2024, p. 229). In Morocco, endometrial cancer is the third most common gynecological cancer, according to a study conducted at the Military Hospital of Rabat. It mainly affects postmenopausal women, and its symptoms include abnormal bleeding, particularly after menopause.

Two histological types of endometrial cancer are distinguished: hormone-dependent endometrioid carcinoma with a good prognosis, and non-hormone-dependent non-endometrioid carcinoma with a poor prognosis.

Recent studies on endometrial cancer have established a new purely molecular classification comprising four tumor classes, from best to worst prognosis: ultra-mutated “POLE,” hyper-mutated, low copy-number, and high copy-number.

This new classification opens up new therapeutic possibilities and improves prognosis. This section highlights a scientific literature review on molecular classification and its impact on management.

Keywords: Endometrial Cancer; Magnetic Resonance Imaging (MRI); Radiotherapy

References

1. “National estimates of cancer incidence and mortality in France between 1980 and 2012”. Study based on the Francim network of cancer registries (2022).
2. Felix AS., et al. “Epidemiology of Endometrial Carcinoma: Etiologic Importance of Hormonal and Metabolic Influences”. Molecular Genetics of Endometrial Carcinoma (2016): 3-46.
3. Sharma R. “Descriptive epidemiology of primary liver cancer incidence and mortality in 185 countries: evidence from GLOBOCAN 2018”. Japanese Journal of Clinical Oncology12 (2020): 1370-1379.

Citation

Citation: Madiha Ouchamch., et al. “Molecular Classification of Endometrial Cancer and Its Impact on Management”.Acta Scientific Medical Sciences 10.1 (2026): 55-56.

Copyright

Copyright: © 2026 Madiha Ouchamch., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.