The First Step Into Death: Postulation on Identifying the Initial Irreversible Event That Ends Life

Md Ikbal Husain and Biplab De*

Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala, Tripura-799005, India

*Corresponding Author: Biplab De, Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala, Tripura-799005, India.

Received: October 14, 2025; Published: December 17, 2025

Abstract

Life and death are not sudden events; rather, they are a series of irreversible chemical changes for normal event. There are many unexplained issues related to DNA-RNA, Neuroscience, Soul, life after death etc. knocking almost everyone, then also both the event of life and death have been continuing and continuing under the control of nature. For centuries, both philosophers and scientists have been interested in figuring out the initial stage of this process of death in normal cases. According to recent research, mitochondrial dysfunction more precisely, the opening of the mitochondrial permeability transition pore (mPTP) is the first irreversible event in cellular death. This review explores the biochemical, physiological and philosophical implications of defining the starting point of death. It highlights the cellular conditions necessary for life, the mitochondrial processes that cause permanent harm and how these scientific understandings relate to philosophical viewpoints regarding the nature of life's end. In addition to defining mortality, an understanding of the initial irreversible event of death gives therapeutic opportunities for reducing pathological cell death in serious disorders.

 Keywords: Death; mPTP; Biochemical Regulation; Cellular Dysfunction

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Citation

Citation: Md Ikbal Husain and Biplab De. “The First Step Into Death: Postulation on Identifying the Initial Irreversible Event That Ends Life”.Acta Scientific Medical Sciences 10.1 (2026): 39-43.

Copyright

Copyright: © 2026 Md Ikbal Husain and Biplab De. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.