Determination of Antibacterial Activity of Strepto-Penicillin, Marbofloxacin and Cefoperazone/Sulbactam Against Common Pathogens

Sachin Kumar Jain¹*, Jyotika Sangale², D J Kalita², Vidhi Gautam¹, Anshita Sinha² and Sanjay Shukla¹

¹College of Veterinary Science and Animal Husbandry, N.D.V.S.U, Jabalpur, Madhya Pradesh, India
²Zenex Animal Health India Private Ltd, India

*Corresponding Author: Sachin Kumar Jain, College of Veterinary Science and Animal Husbandry, N.D.V.S.U, Jabalpur, Madhya Pradesh, India.

Received: September 10, 2025; Published: September 30, 2025

Abstract

The study aimed to determine the sensitivity of commonly used antibiotics in veterinary practice, such as Strepto-penicillin, Marbofloxacin and Cefoperazone/sulbactam against different pathogens. The disc diffusion test was applied to test the effectiveness of Strepto-penicillin, Marbofloxacin, and Cefoperazone/sulbactam against ATCC culture of microorganisms. The zones of inhibition produced by Strepto-penicillin were 32 mm, > 40 mm, 22 mm, 24 mm, 29 mm, and 24 mm against E coli, Bacillus cereus, P aeruginosa, Klebsiella pneumoniae, Staphylococcus epidermidis, and Streptococcus agalactiae, respectively. Antimicrobial sensitivity testing (AST) plays a vital role in veterinary medicine, serving as a basis for selecting appropriate antibiotics to treat bacterial infections in animals. The study found that the selected bacteria were found sensitive for antibiotics i.e., Marbofloxacin, Cefoperazone-Sulbactam, and Strepto-penicillin. This finding is especially important in light of numerous studies documenting the growing resistance to newer classes of antibiotics, such as third-generation cephalosporins. Continuous monitoring of antimicrobial susceptibility is crucial for tracking resistance patterns and assessing the spread of resistant bacterial strains.

 Keywords: Antibacterial; Strepto-Penicillin; Marbofloxacin; Cefoperazone/Sulbactam; Antimicrobial Resistance

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Citation

Citation: Sachin Kumar Jain., et al. “Determination of Antibacterial Activity of Strepto-Penicillin, Marbofloxacin and Cefoperazone/Sulbactam Against Common Pathogens”.Acta Scientific Medical Sciences 9.10 (2025): 82-86.

Copyright

Copyright: © 2025 Sachin Kumar Jain., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.