Lyubov G Aistova¹, Anastasiya O Fyodova¹, Tatiana V Miller¹, Olesya V Gruzdova¹, Elena V Bondarchuk², Igor F Turkanov², , Valery G Gryaznov², Alexey G Vaganov²*, Ekaterina A Galkina², Gregory A Flaks², Ahmed D Aslanov³, Murat A Gotyzhev³, Ahmed M Nogmov³, Pranav Vijayakumar⁴

¹Far Eastern State Agrarian University, 675005 Politechnicheskaya str. 86, Blagoveshchensk-na-Amure, Russian Federation; pmif@dalgau.ru
²Concern GRANIT”, Gogolevsky Blvd., 31, 2, 119019 Moscow, Russian Federation; office@granit-concern.ru
³Kabardino-Balkarian State University named after H.M. Berbekov, Nalchik, Russian Federation; dr-aslanov@mail.ru
⁴First Moscow State Medical University of I.M. Sechenov, Moscow, Russian Federation; rectorat@staff.sechenov.ru

*Corresponding Author: Alexey G Vaganov, Concern GRANIT”, Gogolevsky Blvd., 31, 2, 119019 Moscow, Russia; office@granit-concern.ru.

Received: July 10, 2025; Published: July 28, 2025

Abstract

Introduction: The development of new approaches for local therapy and treatment of burns of varying depths remains a critical challenge in modern burn medicine.

Purpose of the Preclinical Study: To evaluate the efficacy of weak, pulsed, non-ionizing, non-thermal electromagnetic fields (EMFs) applied through non-invasive electromagnetic therapy in accelerating the healing of burn wounds in a rabbit model.

Materials and Methods: A non-randomized preclinical study was conducted at the educational vivarium of the Far Eastern State Agrarian University (Russia) using 24 rabbits (average age: 1.5 years; weight: 3.2 kg), divided equally into two groups. The control group received only 0.9% NaCl wound irrigation. The experimental group was exposed to non-invasive EMF therapy at a distance of 12 meters from the device, in addition to standard NaCl treatment. The total study duration was 30 days.

Results: The experimental group demonstrated significantly faster wound healing compared to the control. By day 21, the average wound area in the EMF-treated animals was reduced to approximately 1 cm², accompanied by extensive granulation tissue formation. Burn wounds were initially inoculated with a monoculture of Staphylococcus epidermidis (10⁶ CFU/mL), and while similar bacterial growth was observed in both groups initially, pathogenic flora such as E. coli, Pseudomonas aeruginosa, and Proteus spp. were absent from the wounds of the EMF-treated group by the end of the study. Rabbits in the control group exhibited signs of sepsis and multiple organ failure, and all died between days 8-10. In contrast, all animals in the experimental group survived the full study period. Necropsy confirmed acute sepsis in the control group, whereas signs of endotoxemia were observed in a few experimental animals.

Conclusion: The application of non-invasive EMF therapy significantly accelerated burn wound healing in the rabbit model and demonstrated a systemic immunostimulatory effect, resulting in complete survival of animals in the treatment group.

 Keywords: Non-Invasive Electromagnetic Therapy; Pulsed EMF; Non-Ionizing Radiation; Burn Wounds; Burn Disease; Ambustion; Preclinical Trials; HZ

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Citation

Citation: Alexey G Vaganov., et al. “Preclinical Trials of Distant Non-invasive Electromagnetic Therapy Accelerating Burn Wounds Recovery in Model Animals”.Acta Scientific Medical Sciences 9.8 (2025): 67-76.

Copyright

Copyright: © 2025 Alexey G Vaganov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.