Bronagh Mc Gee¹* and Paul Hartel^2,3

¹University of Galway, School of Biological and Chemical Sciences, Ireland
²Sligo University Hospital, Department of Pathology, Ireland
³West Virginia University School of Medicine, USA

*Corresponding Author: Bronagh Mc Gee, University of Galway, School of Biological and Chemical Sciences, Ireland.

Received: June 15, 2025; Published: June 30, 2025

Abstract

To evaluate the presence of intraepidermal histiocytes in drug reactions, we reviewed 20 cases of clinical drug rash and their histologic features. Rashes identified as drug-induced by a team of dermatologists were biopsied. Histologically, the prevalence of intraepidermal histiocytes were quantified using S-100 immunohistochemistry and compared with normal skin sections. We found that the prevalence of intraepidermal histiocytes in drug reactions is twice that of normal skin, as well as a small comparative sample of non-drug induced rashes. S-100 positive intraepidermal histiocytes may be a specific histologic and diagnostic marker for drug-induced rash.

 Keywords: Cutaneous Drug Rash; Drug Eruption; Langerhans Cells; S-100

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Citation

Citation: Bronagh Mc Gee and Paul Hartel. “Intraepidermal Histiocytes as a Histologic Marker of Cutaneous Drug Rash”.Acta Scientific Medical Sciences 9.7 (2025): 132-135.

Copyright

Copyright: © 2025 Bronagh Mc Gee and Paul Hartel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.