AV Troitsky¹*, TN Bystrova¹, AA Rozhkov², NA Mamontov² and KA Rozhkova²

¹Federal Research Centre for Fundamental and Translational Medicine, Novosibirsk, Russia
²Innovative Health Technologies LLC, Novosibirsk, Russia

*Corresponding Author: AV Troitsky, Federal Research Centre for Fundamental and Translational Medicine, Novosibirsk, Russia.

Received: October 14, 2024; Published: November 26, 2024

Abstract

The work provides an experimental assessment of the "anti-age" effectiveness of low molecular weight chitosan (50 kDa). The study was conducted on two in vivo models: the galactose model of accelerated aging in mice (enteral administration of low molecular weight chitosan) and with multiple intradermal administrations of a low molecular weight chitosan solution to intact mice. Both models allow for the evaluation of not only the "anti-age" activity of low molecular weight chitosan but also the fundamental molecular-cellular mechanism of its action. For the quantitative assessment of the "anti-age" activity of low molecular weight chitosan, morphometric analysis of histological samples was used. As a result of the conducted study, it was shown that low molecular weight chitosan possesses pronounced "anti-age" activity on the galactose model of accelerated aging, and this effect also extends to reproductive function. When low molecular weight chitosan is administered intradermally, all morphometric parameters related to fibrillogenesis and angiogenesis are higher than in the control group. Taken together, the obtained results suggest that the "anti-age" activity of low molecular weight chitosan is mediated through the activation of tissue macrophages and the expression of tissue proteases (collagenases, elastases) as physiological factors of skin self-renewal.

 Keywords: Low Molecular Weight Chitosan; Galactose Accelerated Aging Model; "Anti-Age" Activity; Skin Regeneration

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Citation

Citation: AV Troitsky., et al. “Study on the "Anti-Age" Effectiveness of Low Molecular Weight Chitosan”.Acta Scientific Medical Sciences 8.12 (2024): 142-149.

Copyright

Copyright: © 2024 AV Troitsky., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.