Omorodion NT¹*, Iyare GI³, Kiofi Barisuka³, Ajanwanchukwu W⁴ and Ehiremen S²

¹Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Nigeria
²Department of Medical Laboratory Science, Faculty of Applied Sciences, Edo University Uzairue, Edo State, Nigeria
³Rivers state College of Health Sciences and Management Technology, Port Harcourt, River State, Nigeria
⁴Department of Medical Laboratory Science, Federal University, Otuoke, Nigeria

*Corresponding Author: Omorodion NT, Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Nigeria.

Received: July 25, 2024; Published: September 19, 2024

Abstract

Chronic cicatrizing conjunctivitis (CCC) refers to conditions causing inflammation and scarring of the conjunctiva, potentially resulting in impaired vision or blindness. Conditions such as trachoma, pemphigoid, and certain surgical procedures can exacerbate conjunctival scarring. Surgeries, particularly glaucoma filtration, often fail due to scarring at the subconjunctival level, especially at the bleb and sclerostomy sites. Antimetabolites like mitomycin C and 5-fluorouracil have shown effectiveness in reducing scarring in animal models. A thorough understanding of the pathophysiology of conjunctival scarring is essential for developing effective treatments. Both in vivo and in vitro experimental models are critical for studying the mechanisms and potential therapies for conjunctival scarring. This study aims to develop a simplified model to investigate conjunctival wound healing, emphasizing the importance of experimental approaches in translating basic research into clinical applications to improve patient outcomes.

 Keywords: Conjunctival Scarring; Cicatrizing Conjunctivitis; Glaucoma Filtration Surgery; Antimetabolites; Experimental Models

References

1. Vazirani J., et al. “Ocular surface squamous neoplasia and human immunodeficiency virus infection”. Cornea8 (2020): 1012-1017.
2. Azari A A and Arabi A. “Conjunctivitis: A systematic review”. Journal of Ophthalmic and Vision Research4 (2020): 487-510.
3. Magarakis M., et al. “Ocular surface diseases: A comparative study of Stevens-Johnson syndrome and ocular cicatricial pemphigoid”. Ophthalmology2 (2012): 347-352.
4. Hitchings R A and Grierson I. “Clinico pathological correlation in eyes with failed fistulizing surgery”. Transactions of the Ophthalmological Societies of the United Kingdom 1 (1983): 84-88.
5. Addicks E M., et al. “Histologic characteristics of filtering blebs in glaucomatous eyes”. Archives of Ophthalmology5 (1983): 795-798.
6. Desjardins DC., et al. “Wound healing after filtering surgery: The effects of short-term postoperative corticosteroids”. Archives of Ophthalmology 4 (1986): 591-593.
7. Doyle JW., et al. “Intraoperative 5-fluorouracil as an adjunct to glaucoma filtration surgery in the rabbit. Ophthalmology3 (1993): 422-428.
8. Bergstrom T J., et al. “The effects of subconjunctival mitomycin-C on glaucoma filtration surgery in rabbits”. Archives of Ophthalmology11 (1991): 1725-1730.
9. Pfeiffer N., et al. “The role of mitomycin C in modulating the wound healing process after experimental glaucoma filtration surgery: A histopathological study”. Graefe's Archive for Clinical and Experimental Ophthalmology 2 (1981): 106-112.
10. Sheridan CM., et al. “Topical antimetabolites: Correlation of cytotoxicity with in vivo efficacy”. Graefe's Archive for Clinical and Experimental Ophthalmology 11 (1996): 726-731.
11. Joseph JM., et al. “Modifications of the blood-aqueous barrier in experimental glaucoma filtration surgery”. Investigative Ophthalmology and Visual Science11 (1989): 2451-2456.
12. Dart J K. “The conjunctiva in ocular surface disease”. In K. T. Holland & J. A. Dart (Eds. Ocular Surface Disease: Cornea, Conjunctiva and Tear Film (2017): 123-145.
13. Shu D Y., et al. “Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis”. Progress in Retinal and Eye Research 60 (2017): 44-65.
14. Wilson SE., et al. “Stromal-epithelial interactions in the cornea”. Progress in Retinal and Eye Research3 (2012): 293-309.
15. Holland E J and Schwartz GS. “Epithelial stem-cell transplantation for severe ocular-surface disease”. The New England Journal of Medicine22 (1999): 1752-1753.
16. Kenyon KR and Tseng S C. “Limbal autograft transplantation for ocular surface disorders”. Ophthalmology5 (1989): 709-723.
17. Razeghinejad M R., et al. “The changing conceptual basis of trabeculectomy: A review of past and current surgical techniques”. Survey of Ophthalmology2 (2013): 140-161.
18. Rulli E., et al. “Efficacy and safety of trabeculectomy versus drainage devices for open-angle glaucoma: A systematic review and network meta-analysis”. The Lancet9899 (2013): 18-19.
19. Md Noh Y H., et al. “Histopathologic analysis of filtering blebs after mitomycin C trabeculectomy”. Korean Journal of Ophthalmology4 (2014): 318-324.
20. Broadway DC., et al. “The role of postoperative subconjunctival fibrosis in the failure of glaucoma filtration surgery”. Investigative Ophthalmology and Visual Science6 (1998): 873-879
21. Merkoudis N., et al. “Cataract surgery in patients with glaucoma”. Open Journal of Ophthalmology4 (2014): 150-156.
22. Porela-Tiihonen S., et al. “Cataract surgery outcomes in eyes with glaucoma drainage implants”. Journal of Cataract and Refractive Surgery11 (2015): 2453-2460.
23. Takihara Y., et al. “Trabeculectomy with mitomycin C after failed primary trabeculectomy: A multicenter study”. American Journal of Ophthalmology6 (2014): 1168-1176.
24. Zhang Y., et al. “Analysis of mitomycin C induced conjunctival wound healing delay with anterior segment optical coherence tomography in a rabbit model”. Current Eye Research9 (2011): 803-809.
25. Zhang Y., et al. “The utility of anterior segment optical coherence tomography in assessing the structural changes of the conjunctiva and blebs in eyes after trabeculectomy”. British Journal of Ophthalmology7 (2013): 930-933.

Citation

Citation: Omorodion NT., et al. “Histopathological Insights into Conjunctival Scarring”.Acta Scientific Medical Sciences 8.10 (2024): 97-101.

Copyright

Copyright: © 2024 Omorodion NT., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.