Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Review Article Volume 8 Issue 10

Histopathological Insights into Conjunctival Scarring

Omorodion NT1*, Iyare GI3, Kiofi Barisuka3, Ajanwanchukwu W4 and Ehiremen S2

1Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Nigeria
2Department of Medical Laboratory Science, Faculty of Applied Sciences, Edo University Uzairue, Edo State, Nigeria
3Rivers state College of Health Sciences and Management Technology, Port Harcourt, River State, Nigeria
4Department of Medical Laboratory Science, Federal University, Otuoke, Nigeria

*Corresponding Author: Omorodion NT, Department of Medical Laboratory Science, School of Basic Medical Sciences, University of Benin, Nigeria.

Received: July 25, 2024; Published: September 19, 2024

Abstract

Chronic cicatrizing conjunctivitis (CCC) refers to conditions causing inflammation and scarring of the conjunctiva, potentially resulting in impaired vision or blindness. Conditions such as trachoma, pemphigoid, and certain surgical procedures can exacerbate conjunctival scarring. Surgeries, particularly glaucoma filtration, often fail due to scarring at the subconjunctival level, especially at the bleb and sclerostomy sites. Antimetabolites like mitomycin C and 5-fluorouracil have shown effectiveness in reducing scarring in animal models. A thorough understanding of the pathophysiology of conjunctival scarring is essential for developing effective treatments. Both in vivo and in vitro experimental models are critical for studying the mechanisms and potential therapies for conjunctival scarring. This study aims to develop a simplified model to investigate conjunctival wound healing, emphasizing the importance of experimental approaches in translating basic research into clinical applications to improve patient outcomes.

 Keywords: Conjunctival Scarring; Cicatrizing Conjunctivitis; Glaucoma Filtration Surgery; Antimetabolites; Experimental Models

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Citation

Citation: Omorodion NT., et al. “Histopathological Insights into Conjunctival Scarring”.Acta Scientific Medical Sciences 8.10 (2024): 97-101.

Copyright

Copyright: © 2024 Omorodion NT., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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