Luljeta Abdullahu¹*, Armend Jashari¹, Naser Gjonbalaj², Fisnik Kurshumliu³, Nimet Orqusha⁴, Brunilda Haxhiu⁵, Basri Lenjani⁶, Ilir Kurtishi⁵, Ylli Kaçiu^1,2, Fitore Murati⁷ and Vjollca Dedushaj Fazliu⁸

¹Nuclear Medicine Department - University Clinical Center of Kosovo, Republic of Kosovo
²Clinic of Radiology, University Clinical Center of Kosovo
³Institute of Pathology-University Clinical Center of Kosovo, Republic of Kosovo
⁴Professor, Assistant Dr. Faculty of Medicine, University of Prishtina “Hasan Prishtina”, Prishtina, Republic of Kosovo
⁵Oncology Clinic, University Clinical Center of Kosovo, Republic of Kosovo
⁶Emergency Clinic, University Clinical Centre of Kosovo, Republic of Kosovo
⁷Physiotherapeutic - University Clinical Center of Kosovo, Republic of Kosovo
⁸Internal Medicine - Endocrinologist Private Praxis "Vital Health Group" Agim Ramadani n.n. Republic of Kosovo

*Corresponding Author: Luljeta Abdullahu and Armend Jashari, Nuclear Medicine Department - University Clinical Center of Kosovo, Republic of Kosovo.

Received: July 18, 2024; Published: August 23, 2024

Abstract

The aim of this study is to present a rare case of a patient with uveal malignant melanoma who presented with solitary metastases to the thoracic vertebra three years after eye enucleating. Bone metastasis from retinal melanoma is extremely rare and is usually associated with involvement of organs primarily in the liver or lungs.

We report a rare case of a patient with malignant (ocular) melanoma who presented with a single (solitary) metastasis to the thoracic vertebra (Th-11) three years after enucleating, without involvement of other organs. Imaging studies included computed tomography (CT), MRI, whole-body bone scan with 99mTc-MDP, and confirmation via core biopsy.

Discussion: Early detection and a multidisciplinary approach are very important in the management of patients with bone metastases from malignant melanoma.

Conclusion: The involvement of specialists from different fields such as radiology, pathology, medical oncology, radiation oncology, and surgical oncology can lead to a better outcome for the patient. In our case radiation and operative surgery could benefit for patients with solitary bone metastasis to achieve long-term survival.

 Keywords: Uvula Melanoma; CT Scan; MRI; Whole Body Bone Scan; 99mTc-MDP; Dual Head Gamma Camera Siemens; Biopsy

References

1. Patel JK., et al. “Metastatic pattern of malignant melanoma. A study of 216 autopsy cases”. The American Journal of Surgery6 (1978).
2. Reinhardt MJ., et al. “Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: Experience with 250 consecutive patients”. Journal of Clinical Oncology7 (2006).
3. Nocuń A and Chrapko B. “Multiple and solitary skeletal muscle metastases on 18F-FDG PET/CT imaging”. Nuclear Medicine Communications 11 (2015).
4. Shields CL., et al. “Metastasis of Uveal Melanoma Millimeter-by-Millimeter in 8033 Consecutive Eyes”. Archives of Ophthalmology8 (2009): 989-998.
5. Maranduca MA., et al. “Synthesis and physiological implications of melanic pigments (review)”. Oncology Letter5 (2019): 4183–4187.
6. Lee YTN. “Malignant Melanoma: Pattern of Metastasis”. CA Cancer Journal of Clinics3 (1980): 137–142.
7. Gokaslan ZL., et al. “Melanoma metastatic to the spine: A review of 133 cases”. Melanoma Research 10 (2000).
8. Ishii T., et al. “Intramedullary spinal cord metastases of malignant melanoma: an autopsy case report and review of the literature”. Clinical Neuropathology5 (2010): 334-340.
9. Wedin R., et al. “Surgical treatment of skeletal metastases in 31 melanoma patients”. Acta Orthopaedica Belgica 2 (2012).
10. Brountzos E., et al. “Bone metastases from malignant melanoma: a retrospective review and analysis of 28 cases”. (2001).
11. Masoomian B., et al. “Overview of BAP1 cancer predisposition syndrome and the relationship to uveal melanoma”. Journal of Current Ophthalmology. Iranian Society of Ophthalmology 30 (2018): 102–109.
12. O’day SJ., et al. “Metastatic Melanoma: Chemotherapy to Biochemotherapy”. Cancer Control1 (2002): 31-38.
13. Eck JC., et al. “Delayed presentation of metastatic melanoma of the cervical spine”. Orthopedics 2 (2008).
14. Davies H., et al. “Mutations of the BRAF gene in human cancer” (2002).
15. Algazi AP., et al. “Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies”. Cancer21 (2016): 3344–3353.
16. Kaštelan S., et al. “Immunotherapy for Uveal Melanoma - Current Knowledge and Perspectives”. Current Medicinal Chemistry 8 (2019).

Citation

Citation: Luljeta Abdullahu and Armend Jashari., et al. “Solitary Bone Metastases of the Thoracic Spine at Th-11 from Uveal Malignant Melanoma: A Rare Entity and Literature Review - A Rare Case Report”.Acta Scientific Medical Sciences 8.9 (2024): 103-107.

Copyright

Copyright: © 2024 Luljeta Abdullahu and Armend Jashari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.