Aigbiremolen AA¹*, Edebiri OE¹, Akhile AO², Odigie OM³ and Aloamaka CP⁴

¹Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria
²Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria
³Department of Human Physiology, Faculty of Basic Medical Sciences, Edo State University, Uzairue, Edo State, Nigeria
⁴Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria

*Corresponding Author: Aigbiremolen AA, Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.

Received: June 17, 2024; Published: July 30, 2024

Abstract

The study assessed oxidative stress biomarker enzyme activities, side by side a recorded surface ECG on non obese and obese amongst female adult to determine changes in ECG patterns. Twenty (20) consenting adult female subjects were recruited from Ekpoma metropolitans, Edo State. A volume of blood measuring 5ml was taken from the vein of volunteers after their consent was sought. The blood collected was placed in sample bottles customized in lithium heparin and centrifuged at 2500RPM (rounds per minute) for 10minutes.To avoid deterioration, the blood plasma was kept in plain sample bottles and stored in the fridge at appropriate temperature. It was thereafter analyzed for oxidative stress biomarkers concentrations. Oxidative stress biomarker (catalase) activities in Obese and non obese adult females were significantly different p < 0.05 and greater in obese. The mean value catalase of Obese was (84.99 ± 1.235) and Non obese (34.82 ± 1.590). Superoxide Dismutase (u/l) 0.4240 ± 0.008327and 0.2010 ± 0.01810 significantly p < 0.05 greater in obese. Glutathione peroxidase (u/ml) 7.509 ± 0.3769 and 3.389 ± 0.1967 significantly greater p < 0.05 in obese. The overall findings shows that oxidative stress is prominent in obese as evident in the higher values of catalase, Superoxide Dismutase biomarker and Glutathione peroxidase enzyme activities compared to non obese. The lack of these enzymes in the body contributes to the development of varying cardiovascular diseases. The activities of this enzyme was greater in obese than non obese indicating the need for more therapeutic approach that may enhance the availability of this enzymes towards promoting protective cover for individuals predisposed to complex cardiovascular diseases. A similar observation was made in the side by side recorded surface ECG on non obese which indicated an altered ECG wave patterns compared to the obese individuals. Obesity should as a matter of health concern be guided consciously to avoid some cardiovascular and other health challenges.

 Keywords: Obesity; Body Mass Index (BMI)

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Citation

Citation: Aigbiremolen AA., et al. “Electrophysiologic study of ECG and Oxidative Stress in Obese and Non Obese Adult Female in Ekpoma Nigeria”.Acta Scientific Medical Sciences 8.8 (2024): 169-176.

Copyright

Copyright: © 2024 Aigbiremolen AA., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.