Keng Wen Cheng, Carine Aw, Li Chun Lee, May Teng Low, Nadhirah Binte Burhanudin, Hui Ting Ng, Phyllis Ong, Belicia Kah Him Tan and Maurice Han Tong Ling*

School of Health and Nursing, Management Development Institute of Singapore, Singapore and Department of Life Sciences, University of Roehampton, United Kingdom

*Corresponding Author: Maurice Han Tong Ling, School of Health and Nursing, Management Development Institute of Singapore, Singapore.

Received: June 17, 2024; Published: July 16, 2024

Abstract

Moringa oleifera (MO), known for its rich nutritional content and diverse health benefits, has gathered increasing scientific interest over the last 5 years. Thus, this systematic review aims to comprehensively examine recent updates on the beneficial components, health effects, and applications of MO. A systematic search on the benefits of MO was conducted using PubMed as the source database, from 2019 to 2023. Out of 120 articles identified, 27 articles were included in this review after filtration. A total of 3 themes were deduced after analysing the articles; namely, (a) nutritional, antioxidant, and phytochemical content, (b) health benefits and disease prevention, and (c) food fortification and quality analysis. Thematic analysis highlights the variability in the nutritional, antioxidant, and phytochemical content of MO, which can be influenced by several factors. MO also demonstrated beneficial effects in various health conditions, although these effects may depend on the dosage of MO. Moreover, MO may be a promising resource for food fortification.

 Keywords: Moringa oleifera; Miracle Tree

References

1. Pareek A., et al. “Moringa oleifera: An Updated Comprehensive Review of Its Pharmacological Activities, Ethnomedicinal, Phytopharmaceutical Formulation, Clinical, Phytochemical, and Toxicological Aspects”. International Journal of Molecular Sciences3 (2023): 2098.
2. Rode SB., et al. “Nature’s Gold (Moringa Oleifera): Miracle Properties”. Cureus7 (2022): e26640.
3. Abd Rani NZ., et al. “Moringa Genus: A Review of Phytochemistry and Pharmacology”. Frontiers in Pharmacology 9 (2018): 108.
4. Trigo C., et al. “Moringa oleifera: An Unknown Crop in Developed Countries with Great Potential for Industry and Adapted to Climate Change”. Foods1 (2020): 31.
5. Islam Z., et al. “Moringa oleifera is a Prominent Source of Nutrients with Potential Health Benefits”. International Journal of Food Science (2021): 6627265.
6. Rotella R., et al. “The Impact of Moringa oleifera Supplementation on Anemia and other Variables during Pregnancy and Breastfeeding: A Narrative Review”. Nutrients12 (2023): 2674.
7. Trigo C., et al. “Potentiality of Moringa oleifera as a Nutritive Ingredient in Different Food Matrices”. Plant Foods for Human Nutrition (Dordrecht, Netherlands)1 (2023): 25-37.
8. Liu R., et al. “Moringa oleifera: a systematic review of its botany, traditional uses, phytochemistry, pharmacology and toxicity”. The Journal of Pharmacy and Pharmacology3 (2022): 296-320.
9. Foong SC., et al. “Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants”. The Cochrane Database of Systematic Reviews5 (2020): CD011505.
10. Bangar A., et al. “Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury”. Journal of Ethnopharmacology2 (2023): 117153.
11. Louisa M., et al. “Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions”. Frontiers in Pharmacology 13 (2022): 792794.
12. Cuschieri A., et al. “Cerebroprotective effects of Moringa oleifera derivatives extracts against MCAO ischemic stroke: A systematic review and meta-analysis”. Heliyon6 (2023): e16622.
13. Peñalver R., et al. “Nutritional and Antioxidant Properties of Moringa oleifera Leaves in Functional Foods”. Foods (Basel, Switzerland)8 (2022): 1107.
14. González-Burgos E., et al. “Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation”. Nutrients7 (2021): 2203.
15. Fejér J., et al. “First Report on Evaluation of Basic Nutritional and Antioxidant Properties of Moringa Oleifera Lam. from Caribbean Island of Saint Lucia”. Plants (Basel, Switzerland)12 (2019): 537.
16. Gambo A., et al. “A double-blind, randomized controlled trial to examine the effect of Moringa oleifera leaf powder supplementation on the immune status and anthropometric parameters of adult HIV patients on antiretroviral therapy in a resource-limited setting”. PloS One12 (2021): e0261935.
17. Rodrigues JF., et al. “Moringa oleifera Lam. Commercial Beverages: A Multifaceted Investigation of Consumer Perceptions, Sensory Analysis, and Bioactive Properties”. Foods (Basel, Switzerland)11 (2023): 2253.
18. Llorent-Martínez EJ., et al. “Preliminary Phytochemical Screening and Antioxidant Activity of Commercial Moringa oleifera Food Supplements”. Antioxidants (Basel, Switzerland)1 (2023): 110.
19. Gao Q., et al. “Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves”. Molecules (Basel, Switzerland)3 (2022): 678.
20. Duranti G., et al. “Moringa oleifera Leaf Extract Upregulates Nrf2/HO-1 Expression and Ameliorates Redox Status in C2C12 Skeletal Muscle Cells”. Molecules (Basel, Switzerland)16 (2021): 5041.
21. Aprioku JS., et al. “Moringa supplementation improves immunological indices and hematological abnormalities in seropositive patients receiving HAARTs”. African Health Sciences2 (2021): 1-11.
22. Minutolo A., et al. “Plant microRNAs from Moringa oleifera Regulate Immune Response and HIV Infection”. Frontiers in Pharmacology 11 (2020): 620038.
23. Pilotos J., et al. “Moringa oleifera treatment increases Tbet expression in CD4+ T cells and remediates immune defects of malnutrition in Plasmodium chabaudi-infected mice”. Malaria Journal1 (2020): 62.
24. Abd-Elhakim YM., et al. “Prevention of melamine-induced hepatorenal impairment by an ethanolic extract of Moringa oleifera: Changes in KIM-1, TIMP-1, oxidative stress, apoptosis, and inflammation-related genes”. Gene 764 (2021): 145083.
25. Yasoob TB., et al. “Liver transcriptome of rabbits supplemented with oral Moringa oleifera leaf powder under heat stress is associated with modulation of lipid metabolism and up-regulation of genes for thermo-tolerance, antioxidation, and immunity”. Nutrition Research (New York, NY) 99 (2023): 25-39.
26. Afolabi OA., et al. “Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3”. Frontiers in Pharmacology 13 (2022): 989023.
27. Khan F., et al. “Moringa oleifera methanolic leaves extract induces apoptosis and G0/G1 cell cycle arrest via downregulation of Hedgehog Signaling Pathway in human prostate PC-3 cancer cells”. Journal of Food Biochemistry8 (2020): e13338.
28. Khan MI., et al. “Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells”. Journal of Traditional and Complementary Medicine6 (2022): 608-618.
29. Caicedo-Lopez LH., et al. “Colonic metabolites from digested Moringa oleifera leaves induced HT-29 cell death via apoptosis, necrosis, and autophagy”. International Journal of Food Sciences and Nutrition4 (2021): 485-498.
30. Khanam M., et al. “Effects of Moringa oleifera leaves on hemoglobin and serum retinol levels and underweight status among adolescent girls in rural Bangladesh”. Frontiers in Nutrition 9 (2022): 959890.
31. Nurhayati T., et al. “Effect of Moringa oleifera Leaf Powder on Hematological Profile of Male Wistar Rats”. Journal of Blood Medicine 14 (2023): 477-485.
32. Oyeleye SI., et al. “Moringa oleifera leaf and seed inclusive diets influenced the restoration of biochemicals associated with erectile dysfunction in the penile tissue of STZ-induced diabetic male rats treated with/without Acarbose drug”. Journal of Food Biochemistry3 (2021): e13323.
33. Wu Y., et al. “Moringa oleifera leaf supplementation relieves oxidative stress and regulates intestinal flora to ameliorate polycystic ovary syndrome in letrozole-induced rats”. Food Science and Nutrition9 (2023): 5137-5156.
34. Tian H., et al. “Moringa oleifera polysaccharides regulates caecal microbiota and small intestinal metabolic profile in C57BL/6 mice”. International Journal of Biological Macromolecules 182 (2021): 595-611.
35. Zainab B., et al. “In-silico elucidation of Moringa oleifera phytochemicals against diabetes mellitus”. Saudi Journal of Biological Sciences9 (2020): 2299-2307.
36. Liu W-L., et al. “Moringa oleifera Lam Seed Oil Augments Pentobarbital-Induced Sleeping Behaviors in Mice via GABAergic Systems”. Journal of Agricultural and Food Chemistry10 (2020): 3149-3162.
37. Li Y-J., et al. “Moringa oleifera seeds mitigate myocardial injury and prevent ventricular failure induced by myocardial infarction”. American Journal of Translational Research8 (2020): 4511-4521.
38. Adi AC., et al. “The Acceptance and Nutritional Value of Crispy Noodles Supplemented with Moringa oleifera as a Functional Snack for Children in a Food Insecure Area”. Preventive Nutrition and Food Science4 (2019): 387-392.
39. Peñalver R., et al. “Development of Functional Gluten-Free Sourdough Bread with Pseudocereals and Enriched with Moringa oleifera”. Foods (Basel, Switzerland)21 (2023): 3920.

Citation

Citation: Maurice Han Tong Ling., et al. “A 5-Year Systematic Review (1 November 2019 to 31 October 2023) on the Benefits of the “Miracle Tree” (Moringa oleifera)”.Acta Scientific Medical Sciences 8.8 (2024): 108-119.

Copyright

Copyright: © 2024 Maurice Han Tong Ling., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.