Tahseen Bilal Rather¹, G A Bhat¹, Irfan Rashid¹, Sayima Farooq¹, Mir Zubair Ahmad¹, Asgar Ali¹, Asif Ahmad¹, Abid-u-satar¹, Altaf Hussain Khan² and Syed Mudassar¹*

¹Department of Clinical Biochemistry, SKIMS, Srinagar, Kashmir, India
²Department of Microbiology, SKIMS, Srinagar, Kashmir, India

*Corresponding Author: Syed Mudassar, Professor and Head, Department of Clinical Biochemistry, SKIMS, Srinagar, Kashmir, India.

Received: April 27, 2023; Published: February 09, 2024

Abstract

Background: Urea and creatinine are protein metabolites that can be used to evaluate renal function. More importantly, the ratio of blood urea nitrogen (BUN) to creatinine (Cr) is a more valuable measure in predicting many diseases than urea and creatinine alone.

Aim: The purpose of this study was to document the serum urea and creatinine levels, as well as their ratio, in our study population and to investigate their impact on our study population.

Methods: In this retrospective observational study,3181 subjects of all ages were recruited for kidney function test analysis (KFT). The fully automatic Biochemistry analyser (Beckman coulter 5800) was used for Biochemistry analysis. Both urea and creatinine were measured enzymatically.

Results: The median serum urea and creatinine levels documented in mg/dl were as 41 (1QR = 49) and 0.95 (IQR = 0.80). Further, a statistically significant association was found between gender and age group with both urea and creatinine (p value < 0.001). We also found a strong positive correlation between serum urea and creatinine levels, r = 0.69 (p < 0.001). further, a weak to moderate positive correlation was noted between urea and age, r = 0.50 (p value < 0.001)and a weak positive correlation was also observed for creatinine and age, r = 0.40 (p- value <0.001). We also found a high BUN/Cr ratio in males (37:1) and females (40:1). Further, the ratio was also higher in different age groups. Participants < 20 years old presented a ratio of 65:1, however those between 20-40 years old retained a ratio of 33:1, whereas individuals >40 years old showed a ratio of 40:1.

Conclusion: Our findings show that blood levels of both urea and creatinine were within the reference range; nevertheless, the increased serum urea nitrogen to creatinine ratio may be useful in evaluating renal and heart associated problems.

 Keywords: Urea; Creatinine; Acute Kidney Injury; Kashmir; COVID-19

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Citation

Citation: Syed Mudassar., et al. “Role of Blood Urea Nitrogen and Serum Creatinine in Disease: An Observational Retrospective Study from India’s Northernmost State, Kashmir Valley”.Acta Scientific Medical Sciences 8.3 (2024): 55-59.

Copyright

Copyright: © 2024 Syed Mudassar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.