Eban-Odi Luisa Nang and Asanghanwa Milca*

¹Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Bamenda, Bambili, Cameroon

*Corresponding Author: Asanghanwa Milca, Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Bamenda, Bambili, Cameroon.

Received: December 19, 2023; Published: January 19, 2024

Abstract

Introduction: Diabetic foot ulcers are a common complication in patients with diabetes mellitus and are associated with a high risk of amputation.

Aim: To determine the microbial profile of diabetic foot ulcers and the antimicrobial susceptibility of isolates from infected ulcers in patients attending the Regional Hospital Bamenda.

Methods: A cross-sectional hospital-based study conducted from May 2023 to July 2023; involving 25 samples from consenting patients with diabetic foot ulcers. Pus samples were obtained from the base of the ulcers using sterile swabs and inoculated into Mannitol Salt, McConkey, Blood and Sabouraud Dextrose agar. Antibiogram was performed using the Kirby-Bauer disc diffusion technique.

Results: The study included 25 samples, and our results showed that Staphylococcus aureus was the most commonly isolated organism (32%); followed by Pseudomonas spp (24%), Escherichia coli (12%), Klebsiella spp (12%), and Proteus spp (8%). Fungal isolates, specifically from the Candida group were found in 4% of cases. Antimicrobial susceptibility testing revealed multidrug resistance to broad-spectrum antibiotics in most of the isolated microorganisms.

Conclusion: Our findings highlight the diverse microbial nature of diabetic foot ulcers, with Staphylococcus aureus being the predominant pathogen. The high prevalence of multidrug resistance emphasizes the need for alternative treatment approaches in the management of diabetic foot ulcers in this setting.

 Keywords: Diabetic Foot Ulcer; Bacterial Profile; Antimicrobial Susceptibility

References

1. Singer J., et al. “Evaluation and management of lower extremities of ulcers”. NEJM 3 (2018): 302-303.
2. Armstrong DG., et al. “Diabetic foot ulcers and their reoccurrence”. NEJM 24 (2017): 2375-2676.
3. Viliekyte L., et al. “Diabetic foot ulcers a quality-of-life issue”. Diabetes/Metabolism Research and Reviews4 (2001): 246-249.
4. Vuorisalo S., et al. “Treatment of diabetic foot ulcer”. 5.3 (2010): 219-275.
5. Sumbul R., et al. “Management of diabetic foot ulcer”. The Healing leech3 (2011): 315-3300.
6. Armstrong DG., et al. “Diabetic foot infections”. The Lancet14 (2012): 632-642.
7. Tchakounte B., et al. “Microbiological profile of diabetic foot infections in Yaounde”. Pan African Medical Journal 29 (2018).
8. Lilian Akwah., et al. “Bacteriology of Diabetic Foot ulcers with reference to multidrug resistance strains at the Yaounde Central Hospital Cameroon”. Journal of Diseases and Medicinal Plants4 (2015): 53-58.
9. Mesmin Dehayem., et al. “Bacterial profile of diabetic foot infections and antibiotic susceptibility in a specialized diabetes center in Cameroon”. PAMJ (2022).
10. Atlaw A., et al. “Bacterial isolates from diabetic foot ulcers and their antimicrobial resistance profile from selected hospitals in Addis Ababa, Ethiopia”. Frontiers in Endocrinology 13 (2022): 987488.
11. Kengne AP., et al. “Diabetic foot ulcers in Cameroon: can microflora prevalence inform probabilistic antibiotic treatment?” Journal of Wound Care8 (2006): 363.
12. Murshed M. “Bacteriological profile of diabetes foot infection and its effect on limb salvation”. Journal of Surgery Science 1 (2022): 5-21.
13. Shah P., et al. “Bacteriological profile of diabetes foot”. International Surgical Journal2 (2022): 704-709.
14. Kengne Ap., et al. “Admission trends over 8 years of diabetes foot ulceration in a specialized diabetes unit in Cameroon”. The International Journal of Lower Extremity Wounds 8 (2009): 180-186.
15. Alexandre F and Horacio O. “Microbiological species and antimicrobial resistance profile in patients with diabetic foot infections”. Jornal Vascular Braileiro 13 (2014): 289-293.

Citation

Citation: Eban-Odi Luisa Nang and Asanghanwa Milca. “Microbial Profile of Diabetic Foot Ulcers of Patients Attending the Regional Hospital Bamenda (Cameroon)”.Acta Scientific Medical Sciences 8.2 (2024): 19-24.

Copyright

Copyright: © 2024 Eban-Odi Luisa Nang and Asanghanwa Milca. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.