Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 8 Issue 1

Evaluating the Therapeutic Potential of Coenzyme Q10 in Colon Cancer

Aiman Alsaegh1*, Amirah Qadiri2, Ghaida Nojoom3, Alaa Banjar4 and Ramya Sindi1,5

1Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences Umm Al-Qura University, Makkah, Saudi Arabia
2Histopathology Department, Dr. Suliman Alhabib Hospital, Jeddah, Saudi Arabia
3Pathology Department, High Quality Lab, Makkah, Saudi Arabia
4Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
5Hekma School of Education, Health and Behavioural Sciences, Dar Al-Hekma University, Jeddah, Saudi Arabia

*Corresponding Author: Aiman Alsaegh, Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences Umm Al-Qura University, Makkah, Saudi Arabia.

Received: December 22, 2023; Published: December 28, 2023

Abstract

Colorectal cancer (CRC) is the third most common malignancy around the world. Chemotherapy, particularly 5- Fluorouracil (5-FU), is the current first-line treatment strategy for CRC. However, chemoresistance restricted the therapeutic effectiveness of 5-FU, necessitating the exploration of novel treatment protocols. A growing body of evidence supported the efficacy of coenzyme Q10 (CoQ10) as a therapeutical option for pathological disorders. The study aimed to evaluate the potential therapeutic effect of CoQ10 as single or combined with 5-FU against CRC. The HCT116 cell lines were treated with monotherapy of CoQ10, 5-FU, and combined therapy for 48 hours, prior to the cell cycle and gene expression analysis. CoQ10 monotherapy arrested the cell cycle at the Sub-G1 phase and significantly increased the expression of p27 (3-fold) and Casp-3 (2.5-fold) while downregulating survivin (2-fold) and PCNA (5.5-fold) gene activity. Marked elevation in cell counts in the S and G2/M phase was observed following both 5-FU and concomitant cotherapy (CoQ10/5-FU). A comparable effect between 5-FU and combined therapy (CoQ10/5-FU) was also observed on the expression of cell cycle regulatory molecules, cell proliferation, and apoptosis markers. CoQ10 monotherapy showed a superior therapeutic effect to 5-FU and dual therapy (CoQ10/5-FU) highlighting it as a promising complementary/alternative candidate in CRC treatment possibly through its phenolic antioxidant activity and its role in mitochondrial respiration.

 Keywords: Colorectal Cancer; Fetal Bovine Serum; World Health Organization

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Citation

Citation: Aiman Alsaegh., et al. “Evaluating the Therapeutic Potential of Coenzyme Q10 in Colon Cancer”.Acta Scientific Medical Sciences 8.1 (2024): 107-113.

Copyright

Copyright: © 2024 Aiman Alsaegh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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