Kosayev JV¹*, Hasanov IA², Abushov NS¹, Ahmedov MB¹, Taghi-zade GT¹, Quliyev RA¹, Ibrahimova GR¹, Ahmadov S¹ and Murvaladova NF¹

¹Scientific Center of Surgery Named After Academician M.A. Topchubashev, Baku, Azerbaijan
²Azerbaijan State Advanced Training Institute for Doctors Named After A. Aliyev, Baku, Azerbaijan

*Corresponding Author: Kosayev JV, Scientific Center of Surgery Named After Academician M.A. Topchubashev, Baku, Azerbaijan.

Received: November 22, 2023; Published: December 13, 2023

Abstract

Background: Given the pathogenetic role of dyslipidemia in the development of chronic critical ischemia, correction of lipid metabolism is important in complex surgical treatment.

Purpose: To study the state of lipid metabolism and the possibility of its correction in patients with critical ischemia of the lower extremities with indirect revascularization

Material and Methods: Studies were conducted in 65 patients with critical ischemia of the lower extremities of atherosclerotic and thrombangiitic genesis. In 34 patients, indirect revascularization was performed with generally accepted conservative treatment in the perioperative period. (control group). In 31 patients, revascularizing osteotrepanation with intraosseous laser irradiation with intravenous laser irradiation and cytokine therapy in the perioperative period in parallel with generally accepted treatment. (main group). In dynamics, the parameters of lipid metabolism were studied - total cholesterol, low and very low density lipoproteins, high-density lipoproteins, triglycerides, atherogenic coefficient. The reference group consisted of 48 practically healthy individuals. The obtained data were processed by parametric and non-parametric statistics. The compared groups were the same in terms of age and sex, the level of arterial damage, the duration of arterial damage and the duration of the development of critical ischemia, the nature and volume of generally accepted conservative treatment in the perioperative period.

Results: Upon admission to the clinic, a sharp violation of lipid metabolism was revealed - dyslipidemia: a significant increase in the pro-atherogenic fraction (р = 0,023-0,004) a significant decrease in the anti-atherogenic fraction (p = 0.0005) of the lipid spectrum. At the end of in patient treatment, patients of the control group observed an unreliable (р = 0,322-0,066) correction of dyslipidemia. In the main group, before discharge from the hospital, a significant decrease (р = 0,003-0,000007) of proatherogenic fractions and an increase (р = 0,0038) of the antiatherogenic fraction were detected. Correlation-statistical analysis revealed a significant dependence (p < 0.001) of lipid spectrum correction on the method of treatment in the perioperative period with a pronounced correlative relationship (r = 0.6-0.7).

Conclusion: The obtained data make it possible to assert that the use of intravenous laser irradiation of blood and cytokine therapy with a recombinant interleukin-2 preparation in the perioperative period with revascularizing osteotrepanation with intramedullary laser irradiation significantly levels the studied parameters of lipid metabolism, except for total cholesterol.

 Keywords: Critical Lower Limb Ischemia; Lipid Metabolism; Revascularizing Osteotrepanation with Intramedullari Laser Irradiation; Intravenous Laser Irradiation of Blood; Cytokine Therapy

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Citation

Citation: Kosayev JV., et al. “Lipid Metabolism Disorders and its Correction in Patients with Critical Lower Limb Ischemia During Revascularizing Osteotrepanation with Intramedullary Laser Irradiation Using Intravenous Laser Irradiation and Cytokine Therapy in the Perioperative Period”.Acta Scientific Medical Sciences 8.1 (2024): 03-08.

Copyright

Copyright: © 2024 Kosayev JV., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.