Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Case Report Volume 7 Issue 8

Hyperandrogenism of Tumor Origin in Adolescence: A Case Report

Clemente-Tomás CP1*, Cabeza-Vengoechea PJ1, Colechá-Morales M1, Domingo-Barrado MI1, Giménez-Campos MI1, Moreno-Sanz L2, Martín-Calama Valero J3, Garcés-Valenzuela M4

1Specialist in Gynecology and Obstetrics. Hospital Obispo Polanco, Teruel, Spain
2Nurse specialized in Gynecology and Obstetrics, Hospital Obispo Polanco, Teruel, Spain
3Head of the Department of Pediatrics, Hospital Obispo Polanco, Teruel, Spain
4Head of the Department of Gynecology and Obstetrics, Hospital Obispo Polanco, Teruel, Spain

*Corresponding Author: Clemente-Tomás CP, Specialist in Gynecology and Obstetrics. Hospital Obispo Polanco, Teruel, Spain.

Received: June 19, 2023; Published: July 19, 2023


A case is presented of hyperandrogenism with signs of virilization in an adolescent female. The symptoms include deepening of the voice, marked acne on the face and upper back, increased hair in the genital area and buttocks, and amenorrhoea of two months' duration. The patient was diagnosed with ovarian Sertoli-Leydig cell tumor on the basis of blood tests, gynaecological ultrasound and magnetic resonance imaging. She underwent laparoscopic unilateral adnexectomy, with immediate normalization of the laboratory test findings and progressive clinical improvement following surgery.

 Keywords: Hyperandrogenism; Amenorrhoea; Magnetic Resonance Imaging (MRI); Laparoscopic Unilateral Adnexectomy


  1. Young RH and Scully RE. “Sex cord-stromal, steroid cell, and other ovarian tumors with endocrine, paraendocrine, and paraneoplastic manifestations”. Kurman RJ: Blausteins pathology of the female genital tract. New York: Springer-Verlag. (2002):905-966.
  2. Flores OR. “Tumor de células de Sertoli-Leydig (arrenoblastoma) malign”. Rev Méd Hondureisia 59 (1991): 29-33.
  3. J López-Olmosa and J Alcacer. “Tumor maligno de ovario de células de Sertoli-Leydig. Malignant ovarian tumour of Sertoli Leydig cells. A clinical case”. Clínica e Investigación en Ginecología y Obstetricia5 (2000): 184-189.
  4. I Sandoval Díaz., et al. “Tumor de células de Sertoli-Leydig: a propósito de un caso”. Revista Peruana de Ginecología y Obstetricia. Lima 60.3 (2014): 245-251.
  5. Pilch YH. “Surgical Oncology”. New York: McGraw-Hill Book company (1984): 625-35.
  6. R Sarabia Ochoa., et al. “Tumor de células de Sertoli-Leydig del ovario; un tumor virilizante poco frecuente. Dos casos clinicopatológicos”. Progresos de Obstetricia y Ginecología5 (2015): 238-242.


Citation: Clemente-Tomás CP., et al. “Hyperandrogenism of Tumor Origin in Adolescence: A Case Report”.Acta Scientific Medical Sciences 7.8 (2023): 139-142.


Copyright: © 2023 Clemente-Tomás CP., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is September 30, 2023.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US