Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Review Article Volume 7 Issue 8

Protocol Targeted Temperature Management

Dmitry V Cheboksarov1* and Olga V Ryzhova2

1PHD, Senior Researcher, FGBNU "FNCC RR", Moscow, Russia
2Medical Rehabilitation Doctor FGBNU "FNCC RR", Moscow, Russia

*Corresponding Author: Dmitry V Cheboksarov, PHD, Senior Researcher, FGBNU "FNCC RR", Moscow, Russia.

Received: May 29, 2023; Published: July 07, 2023


Therapeutic hypothermia (TH), as the main method of targeted temperature management (TTM), consists of the use of neurovegetative blockades and general cooling of the body. TTM has been widely used in clinical practice since the mid-twentieth century thanks to the work of the scientific school of Bigelow, Rozomoff, Safar, and their followers.

The use of the TTM method significantly improved the effectiveness of shock therapy, significantly increasing the period of reversible changes in the central nervous system (CNS) during total ischemia and reducing the neurological consequences of neurotrauma. This led to its widespread use in intensive care, cardio- and neurosurgery, and traumatic brain injury treatment. The large volume of experimental and clinical studies performed allows us to reasonably consider TTM as a neuroprotection method that has a positive effect on most of the key mechanisms of secondary neuron damage.

Thus, the depression of metabolism in cells due to hypothermia is considered an important component of the neuroprotective effect of TTM. Reducing the need for oxygen and ATP helps to reduce the reactions of neurons to ischemia and lengthen the period of their life in hypoperfusion. Restriction of local inflammation in ACA and neurotrauma during hypothermia is accompanied by a decrease in leukocyte migration and infiltration of brain tissue by them, decreased edema, and decreased ICP. TTM reduces the amount of damage to the nervous tissue and neuronal death.

In this article, we propose our own TTM protocol based on our own and international experience of conducting hypothermia.

 Keywords: Therapeutic Hypothermia (TH); Targeted Temperature Management (TTM); Stroke; CPR


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Citation: Dmitry V Cheboksarov and Olga V Ryzhova. “Protocol Targeted Temperature Management”.Acta Scientific Medical Sciences 7.8 (2023): 59-67.


Copyright: © 2023 Dmitry V Cheboksarov and Olga V Ryzhova. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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