Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Case Report Volume 7 Issue 8

Pediatric Lupus and Congenital HIV, A Rare Association with Difficult Therapeutic Management: A Case Report from Burkina Faso

Wendyam Nadège Yameogo 1, Ismael Ayouba Tinni1*, Wendlassida Stéphanie Joelle Zabsonre/Tiendrebeogo1,2, Fulgence Kabore1,2, Marcellin Bonkoungou1 and Dieu-Donné Ouedraogo1,2

1Rheumatology Department, CHU Bogodogo, Burkina Faso
2Joseph KI-ZERBO University, Burkina Faso

*Corresponding Author: Ismael Ayouba Tinni, Rheumatology Department, CHU Bogodogo, Burkina Faso.

Received: June 29, 2023; Published: July 06, 2023

Abstract

Introduction: The coexistence of congenital acquired immunodeficiency syndrome with systemic lupus erythematosus (SLE) is rare, especially in the pediatric population. We report a pediatric case, the first case reported in Burkina Faso.

Observation: This was an 11-year-old female patient, seropositive to human immunodeficiency virus (HIV) type 1, followed since the age of 18 months with an undetectable viral load, on Abacavir-Dolegravir-Ritonavir/day and cotrimoxazole. She was admitted for chronic inflammatory polyarthralgia associated with exertional dyspnea, of chronic evolution in a context of altered general condition. The immunological work-up noted: positive antinuclear = 1280 IU/ml. Anti DNA antibody = 380 IU/ml, anti Sm antibody = 33U/ml, anti-histone antibody negative. The diagnosis of systemic lupus erythematosus in HIV was retained.

Conclusion: SLE and HIV are two pathologies with some clinical similarities, but the therapeutic objectives and the medication are divergent to the point where the association of the two in the same patient complicates the management.

 Keywords : SLE; Child; HIV; Burkina Faso

References

  1. Meyer O and Kahn MF. “Lupus érythémateux disséminé”. In: Kahn MF, Peltier AP, Meyer O, Piette JC, editors. Les maladies systémiques. Paris: Flammarion-Médecine Sciences; (2000): 131-368.
  2. Bader-Meunier B., et al. “Initial presentation of childhood-onset systemic lupus erythematosus: a French multicenter study”. Journal of Pediatrics5 (2005): 648-653.
  3. Contreras G., et al. “Systemic lupus erythematosus in two adults with human immunodeficiency virus infection”. American Journal of Kidney Diseases2 (1996): 292295.
  4. Bs N., et al. “Systemic lupus erythematosus in the setting of HIV-1 infection: a longitudinal analysis”. Clinical Rheumatology2 (2020).
  5. D’Agati V and Seigle R. “Coexistence of AIDS and lupus nephritis: a case report”. American Journal of Nephrology3 (1990): 243‑347.
  6. O’Keefe K., et al. “Systemic lupus erythematosus in a pediatric patient with congenital acquired immunodeficiency syndrome”. The Pediatric Infectious Disease Journal4 (2001).
  7. Kopelman RG and Zolla-Pazner S. “Association of human immunodeficiency virus infection and autoimmune phenomena”. American Journal of Medicine1 (1988): 82-88.
  8. Sacilotto Nde C., et al. “Juvenile systemic lupus erythematosus in a adolescent with acquired immunodeficiency syndrome”. Revista Brasileira de Reumatologia4 (2010).
  9. Mialou V., et al. “Lupus nephritis in a child with AIDS”. American Journal of Kidney Diseases4 (2001).
  10. Deapen D., et al. “A revised estimate of twin concordance in systemic lupus erythematosus”. Arthritis and Rheumatism 35 (1992): 311-318.
  11. Liu M., et al. “Polyreactivity and autoreactivity among HIV-1 antibodies”. Journal of Virology 89 (2015): 784-798.
  12. Massabki PS., et al. “Clinical implications of autoantibodies in HIV infection”. AIDS 11 (1997): 1845-1850.
  13. Esteva MH., et al. “False positive results for antibody to HIV in two men with systemic lupus erythematosus”. Annals of the Rheumatic Diseases 51 (1992): 1071-1073.
  14. Mody Gm., et al. “Concomitant systemic lupus erythematosus and HIV: case series and literature review”. Seminars in Arthritis and Rheumatism2 (2014): 186‑184.
  15. Diri E., et al. “Emergence of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for human immunodeficiency virus infection”. The Journal of Rheumatology11 (2000).

Citation

Citation: Ismael Ayouba Tinni., et al. “Pediatric Lupus and Congenital HIV, A Rare Association with Difficult Therapeutic Management: A Case Report from Burkina Faso”.Acta Scientific Medical Sciences 7.8 (2023): 49-51.

Copyright

Copyright: © 2023 Ismael Ayouba Tinni., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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