Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 7

The Effect of GLP-1 on the Incidence of Cardiovascular Events Compared to Bariatric Surgery: Systematic Review

Njood A Alshowigi1, Mashael A Aluraifej2, Najla A Almarshad3, Saleh A Alshowigi4, Tarik Alsaid1, Shahad Alwathnani1 and Mostafa Kofi1*

1Department of Family Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
2Department of Internal Medicine, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia
3Department of Internal Medicine, King Saud Medical City, Riyadh, Saudi Arabia
4King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

*Corresponding Author: Mostafa Kofi, Department of Family Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Received: June 06, 2023; Published: June 22, 2023


Introduction: Worldwide obesity has become one of the most common public health concerns. In addition to being an increased mortality risk factor, it also contributes to type 2 diabetes, hypertension, heart disease, and some types of cancer. On aiming to reduce body mass index multiple measures are scientifically investigated such as lifestyle modification, pharmacological and surgical therapy. This review took a critical look on evaluating the scientific evidence of GLP-1 Vs bariatric surgery and the outcome of cardiovascular events.

Methods: PubMed, Google Scholar and Research Gate were searched for recent studies published in the period between 2010 and 2021.

Results: A total of 16 studies with 283983 patients were included in this review. Of these, 77316 patients were in the intervention groups representing 27.2% of the overall studied population. Around 9% of patients were in the bariatric surgery group, while 18% were in the GLP-1 group. Nine studies used bariatric surgery as their primary intervention, while seven used GLP-1. The mean age of participants ranged from 32.4 to 66 years.

Conclusion: In conclusion, GLP-1 showed similar event rates to the control group for MI and CVD but better stroke outcomes. Moreover, bariatric surgery, across studies demonstrated a significant reduction in the risk of the studied events. Thus, we recommend conducting high-quality trials comparing the two interventions to safely apply the results in everyday practice.

 Keywords: Bariatric Surgery; GLP-1; Obesity; Cardiovascular Events; Myocardial Infarction; Cerebrovascular Accident


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Citation: Mostafa Kofi., et al. “The Effect of GLP-1 on the Incidence of Cardiovascular Events Compared to Bariatric Surgery: Systematic Review”.Acta Scientific Medical Sciences 7.7 (2023): 121-131.


Copyright: © 2023 Mostafa Kofi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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