Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Case Report Volume 7 Issue 5

Malignant Transformation of Neurofibroma with Emphasis on S100 - A Rare Case

Varshini Sindhiya Chanda1* and Neethu GV2

1Postgraduate, JJM Medical College, RGUHS, Karnataka, India
2Associate Professor, JJM Medical College, RGUHS, Karnataka, India

*Corresponding Author: Varshini Sindhiya Chanda, Postgraduate, JJM Medical College, RGUHS, Karnataka, India.

Received: March 14, 2023; Published: April 29, 2023


Malignant peripheral nerve sheath tumor (MPNST) is a rare neoplasm arising from peripheral nerve and may arise from a pre-existing nerve sheath tumor in neurofibromatosis type 1 (NF 1). This is a rare case of 26 year old female presented with swelling on posterior aspect of left thigh since 1 month. Fine needle aspiration cytology (FNAC) suggestive of Malignant spindle cell tumour. Surgery was done and specimen sent for biopsy showed transformation from Neurofibroma to Malignant peripheral nerve sheath tumour (MPNST). Immunohistochemistry with S-100 protein was diffusely positive. Complete surgical resection with wide negative margins is the optimum management of high-grade MPNST and that early diagnosis and potential prevention of MPNST should be prioritized. The 5-year overall survival (OS) rate of all patients with MPNST was 69.5%. Whereas the precursors for MPNST like neurofibroma should be surgically resected and wide margins is not necessary, and preservation of neurological function is of paramount importance. Thus the management of neurofibroma differs from MPNST as the survival rate of the former is better than the latter.

 Keywords: Biopsy; Fine- Needle; Immunohistochemistry; Adult; Female


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Citation: Varshini Sindhiya Chanda and Neethu GV. “Malignant Transformation of Neurofibroma with Emphasis on S100 - A Rare Case”.Acta Scientific Medical Sciences 7.5 (2023): 214-216.


Copyright: © 2023 Varshini Sindhiya Chanda and Neethu GV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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