Bharat Patodiya*¹, GV Rao², Anuradha Sekaran³, Meenakshi Chowdhury⁴, Tharni putta⁵ and D Nageshwar Reddy⁶

¹Department of Medical Oncology, Omega Hospitals, Hyderabad, India
²Chief and Head surgical Gastroenterologist, AIG Hospitals, Hyderabad, India
³Consultant Pathologist AIG Hospitals, India
⁴Director Dhanvantari Implant clinic, New Delhi, India
⁵Consultant Radiologist, AIG Hospitals, India
⁶Chairman and Chief of Gastroenterology AIG Hospitals, India

*Corresponding Author: Bharat Patodiya, Department of Medical Oncology, Omega Hospitals, Hyderabad, India.

Received: March 20, 2023; Published: April 18, 2023

Abstract

We report the case of a 50-year-old female who presented with blood-stained vomiting. Physical exam and laboratory studies was unremarkable. USG abdomen revealed thickening of walls of body of stomach with peri gastric oedema. A contrast CT scan suggestive of polypoidal endophytic growth in the distal body of stomach with left lower lobe lung 3mm deposit. Endoscopy biopsy from stomach was suggestive of poorly differentiated malignancy and immunohistochemical staining demonstrating patchy positivity CD43, CD45 and BCL-2 positivity. Whole body positron emission tomography (18-FDG-PET/CT) demonstrated metabolically active heterogeneously enhancing polypoidal soft tissue mass in the body of the stomach along the greater curvature as described - Primary. Low grade metabolically active few tiny peri gastric lymph nodes were also involved. Metabolically active tiny soft tissue nodule in the left lower lobe was described metastatic. Since the IHC markers PanCK and chromogranin negativity allowed to suspect primary gastric melanoma in this patient. The treatment of oligo metastatic Melanoma patients underwent gastrectomy along with gastrojejunostomy jejunojejunostomy. Very few cases of primary gastric melanoma have been reported. We report this case and presents the rarity of treatment design.

Keywords: Melanoma; Surgery; Gastric; Gastrointestinal

References

1. Grilliot MA, Goldblum JR, Liu X.Signetring cell melanoma of the gastroesophageal junction: a case report and literature review. Arch Pathol Lab Med 2012;136:324-8.
2. Syed HR, Shekar S, Aravantagi A. Melanoma and the Gastrointestinal (GI) Tract: Maintaining a High Index of Suspicion. Cureus. 2021;13(2):e13408. Published 2021 Feb 18. doi:10.7759/cureus.13408.
3. Wang J, Yang F, Ao WQ, Liu C, Zhang WM, Xu FY. Primary gastric melanoma: A case report with imaging findings and 5-year follow-up. World J Gastroenterol 2019; 25(44): 6571-6578.
4. Piris A, Rosai J. Pigmented lesions in unusual anatomic sites. Semin Diagn Pathol. 2003;20:249–59
5. Jora C, Pankaj P, Verma R, Jain A, Belho ES. Primary malignant melanoma of the esophagus. Indian J Nucl Med. 2015;30(2):162-164. doi:10.4103/0972-3919.152983
6. Augustyn A, de Leon ED, Yopp AC. Primary gastric melanoma: case report of a rare malignancy. Rare Tumors. 2015;7(1):5683. Published 2015 Mar 27. doi:10.4081/rt.2015.5683
7. Smalley KS, McArthur GA. The current state of targeted therapy in melanoma: this time it’s personal. Sem Oncol2012;39:204-14

Citation

Citation: Bharat Patodiya., et al. “Rare Case Report- Melanoma Stomach”.Acta Scientific Medical Sciences 7.5 (2023): 134-137.

Copyright

Copyright: © 2023 Bharat Patodiya., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.